Possible mechanism for differences in sensitivity to cis-platinum in human prostate tumor cell lines.

Abstract:

:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although these factors have been postulated to play a role in the mechanism(s) of resistance to cis-Pt in other cell types, preliminary data in this report suggest that differences found in drug uptake and subsequent binding to DNA are most likely responsible for variations in cis-Pt sensitivity displayed by these prostate tumor cell lines.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Metcalfe SA,Cain K,Hill BT

doi

10.1016/0304-3835(86)90007-8

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

163-9

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(86)90007-8

journal_volume

31

pub_type

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