Abstract:
:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although these factors have been postulated to play a role in the mechanism(s) of resistance to cis-Pt in other cell types, preliminary data in this report suggest that differences found in drug uptake and subsequent binding to DNA are most likely responsible for variations in cis-Pt sensitivity displayed by these prostate tumor cell lines.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Metcalfe SA,Cain K,Hill BTdoi
10.1016/0304-3835(86)90007-8subject
Has Abstractpub_date
1986-05-01 00:00:00pages
163-9issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(86)90007-8journal_volume
31pub_type
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