Abstract：
:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in copy number of this clone from 5- to 25- fold; erb-b amplification was found in 8/45 (18%). This clone revealed homology to non-continuous mitochondrial DNA positions 1679-1948 and 2017-2057, with the interspersed sequences deleted. A non-mitochondrial genomic addition of 15 bases at the 5' end of the clone and a 7 base insertion adjacent to position 1948 were also present. Evaluation of the entire mitochondrial genome in a subset of 11 tumors showed maximal amplification between mitochondrial positions 748 and 5882, and a lower degree of amplification elsewhere, with a recurrent deletion of a 1.2 kb EcoRI fragment noted in 5/11 (46%) tumors. The mitochondrial genome is frequently affected in human gliomas, and warrants further study to determine its role in glial malignancy.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Liang BC,Hays Ldoi
10.1016/0304-3835(96)04276-0subject
Has Abstractpub_date
1996-08-02 00:00:00pages
167-73issue
2eissn
0304-3835issn
1872-7980pii
0304383596042760journal_volume
105pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract：:We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3 inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression and inhibited JAK2 phosphorylation which leads to inhibition of STAT3 phosphorylation. OPB-31121 inhibited constitutively activated and IL-6-i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.02.010
更新日期：2013-07-10 00:00:00
abstract：:Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(79)80042-7
更新日期：1979-04-01 00:00:00
abstract：:Most brain tumors are highly resistant to chemotherapy because many chemotherapeutic drugs poorly cross the blood-brain barrier, the blood-cerebrospinal-fluid barrier, and the plasma membrane of the tumor cells. This restricted drug delivery is largely due to the presence of integral plasma membrane proteins belonging...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2006.12.023
更新日期：2007-08-28 00:00:00
abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(77)93723-5
更新日期：1977-07-01 00:00:00
abstract：:Aberrant expression of many long non-coding RNAs has been observed in various types of cancer, implicating their crucial roles in tumorigenesis and cancer progression. Emerging knowledge with regard to the critical physiological and pathological roles of long non-coding RNAs in cancers makes them potential targets in ...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2018.01.042
更新日期：2018-04-01 00:00:00
abstract：:Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed tha...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2014.11.002
更新日期：2015-02-01 00:00:00
abstract：:The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(79)90007-7
更新日期：1979-12-01 00:00:00
abstract：:Stress conditions induced by routine treatments might affect cancer-associated fibroblasts in lung adenocarcinoma. The present study tried to explore transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and anti-angiogenesis ther...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.10.032
更新日期：2021-01-28 00:00:00
abstract：:Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(00)00375-x
更新日期：2000-06-01 00:00:00
abstract：:Up-regulation of the urokinase plasminogen activation (uPA) system leads to increased cancer invasion and metastasis. Plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and type-2 (PAI-2/SERPINB2) have similar uPA inhibitory properties yet PAI-1 promotes cell invasion by modulating cell adhesion and migration. H...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2011.01.018
更新日期：2011-04-28 00:00:00
abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2019.03.047
更新日期：2019-07-01 00:00:00
abstract：:Cancer results from the interaction of multiple aberrations including activation of dominant oncogenes and upregulation of signal transduction pathways. Identification of the genes involved in malignant transformation is a pre-requisite for understanding cancer and improving its diagnosis and treatment. Quite a few of...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2007.04.015
更新日期：2007-10-08 00:00:00
abstract：:Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.11.017
更新日期：2014-03-28 00:00:00
abstract：:ArgBP2 is a multi-adapter protein involved in signal transduction associated to the cytoskeleton and was shown to regulate the migration and adhesion of pancreatic cancer cells thereby modulating their tumorigenicity. Here we describe the interaction of ArgBP2 with CIP4, a new associated protein identified by yeast tw...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.06.030
更新日期：2010-02-01 00:00:00
abstract：:Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(91)90115-x
更新日期：1991-12-01 00:00:00
abstract：:Doxycycline has been found to induce apoptosis and to inhibit the growth of a variety of tumor cells, in addition to its use as an antibiotic. However, the mechanism of its actions, especially at the molecular level, remains unknown and needs to be resolved. A crucial step possibly lies in the early period of doxycycl...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2009.05.004
更新日期：2009-11-28 00:00:00
abstract：:Putrescine (PU), spermidine (SPD) and spermine (SPM) levels in blood serum of MC Sa 1828 P-bearing rats have been studied in relation to tumour weight and the histological picture. A statistically significant increase of PU and SPD was found in the course of tumour development. Decrease in the level of polyamines in t...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(87)90073-5
更新日期：1987-01-01 00:00:00
abstract：:Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is ubiquitously present in eukaryotic cells and archebacteria. In this reaction, deoxyhypusine synthase catalyzes the conversion of one unique lysine residue on eIF-5A to deoxyhypusine using spermidine as the substrate. Hydroxylation of the d...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/s0304-3835(97)04741-1
更新日期：1997-05-19 00:00:00
abstract：:Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Hypoxia induces metabolic alterations in cancer, thereby promoting aggressive malignancy and metastasis. While previous efforts largely focused on adaptive responses in glucose and glutamine metabolism, recent studies have begun to yield i...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2020.06.013
更新日期：2020-11-28 00:00:00
abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(89)90104-3
更新日期：1989-01-01 00:00:00
abstract：:Tumor biopsies obtained from 25 Saudi Arab patients with nasopharyngeal carcinoma (NPC) were examined for the presence of Epstein-Barr virus (EBV) DNA detected by the polymerase chain reaction (PCR) and for the incidence of p53 mutations screened by a combination of PCR, single strand conformation polymorphism (SSCP) ...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(94)90011-6
更新日期：1994-07-29 00:00:00
abstract：:Chimeric antigen receptor (CAR) T cell therapy is one of the most promising immunotherapies in the past decade. It brings hope for cure to patients with previously refractory hematological malignancies. However, when translating this strategy into non-hematologic malignancies, the antitumor activity from multiple clin...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2021.01.014
更新日期：2021-01-19 00:00:00
abstract：:Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 cont...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/j.canlet.2013.01.013
更新日期：2013-05-10 00:00:00
abstract：:Under most circumstances, hepatitis B virus (HBV) is noncytopathic. However, hepatocellular regeneration that accompanies each bout of hepatitis appears to be associated with increased integration of HBV DNA fragments expressing the virus encoded hepatitis B x antigen (HBxAg). Intrahepatic HBxAg staining correlates wi...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2008.12.010
更新日期：2009-12-01 00:00:00
abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.01.001
更新日期：2020-03-31 00:00:00
abstract：:The recurrence rate of soft tissue and bone sarcomas strongly correlates to the status of the surgical margin after excision, yet excessive removal of tissue may lead to distinct, otherwise avoidable morbidity. Therefore, adequate margination of sarcomas both pre- and intra-operatively is a clinical necessity that has...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2020.03.029
更新日期：2020-07-28 00:00:00
abstract：:Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therape...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2016.11.019
更新日期：2017-02-01 00:00:00
abstract：:The effect of magnesium hydroxide on the epithelial proliferation of the large bowel was examined using rats given methylazoxymethanol (MAM) acetate. Dietary administration of magnesium hydroxide at 250, 500, 1000 or 2000 ppm. for 1, 3 or 5 weeks did not influence the cell cycle of the cryptal cells of the large bowel...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(92)90196-3
更新日期：1992-02-14 00:00:00
abstract：:In this study we demonstrate the involvement of ras oncogenes in bladder cancer at the level of RNA overexpression. We examined 26 bladder specimens, consisting of paired tumor and adjacent normal tissue and found that H-ras transcripts were overexpressed in 39% of the specimens while K-ras and N-ras in 58% of total s...
journal_title：Cancer letters
pub_type： 杂志文章
doi：10.1016/0304-3835(96)04372-8
更新日期：1996-10-22 00:00:00
abstract：:The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...
journal_title：Cancer letters
pub_type： 杂志文章,评审
doi：10.1016/j.canlet.2013.07.029
更新日期：2014-09-28 00:00:00
