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Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells.

Abstract：

:Circulating glucose-regulated protein 78 (GRP78) autoantibodies represent potential biomarker of epithelial ovarian cancer. However there is relatively limited identification of these antibodies in response to ovarian cancer. Here, we were interested in characterization of these antibodies and into their role in tumor development. We first purified GRP78 autoantibodies from sera of patients with ovarian cancer, and then tested them on SKOV-3 ovarian cancer cell line. A decrease of invasion and an increase of H(2)O(2)-induced apoptosis of SKOV-3 cells were observed, suggesting their protective role against ovarian cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cohen M,Petignat P

doi

10.1016/j.canlet.2011.05.022

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

104-9

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(11)00288-6

journal_volume

309

pub_type

杂志文章

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