Abstract:
:The capacity of enteric bacteria (E. coli, Salmonella, Pseudomonas, Shigella and Klebsiella) to catalyze the covalent binding of benzo(a)pyrene (BP), cholic acid, deoxycholic acid and cholesterol was investigated. In general, these bacteria were incapable of activating BP to a covalently bound product with calf thymus DNA. Metabolism studies of BP by fluorometric assay failed to indicate any accumulation of BP-3-hydroxy in the incubation medium. Detailed metabolic investigation with high-pressure liquid chromatography indicated that these bacteria did not produce any known metabolites which are formed by mammalian systems. However, radioactivity was detected in all fractions, suggesting that the bacteria were readily metabolizing BP into smaller molecules for energy and carbon sources. Although the enteric bacteria did not metabolize BP into known metabolites, some were capable of activating cholesterol, cholic acid and deoxycholic acid to covalently bound products with DNA. The binding data with cholesterol and bile acids also suggested that the binding process required NADPH as a cofactor because binding level was rather low without NADPH.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zachariah PK,Slaga TJ,Berry DL,Bracken WM,Buty SG,Martinsen CM,Juchau MRdoi
10.1016/s0304-3835(77)94577-3subject
Has Abstractpub_date
1977-07-01 00:00:00pages
99-105issue
1-2eissn
0304-3835issn
1872-7980pii
S0304-3835(77)94577-3journal_volume
3pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::We investigated effects of sex steroids and analogs (estradiol, DES, norgestrel, progesterone, medroxyprogesterone, and testosterone) on the proliferation and survival of 10 human leukemia/lymphoma cell lines (HL-60, K562, U937, CEM, KG-1, Jurkat, U266, H929, PA and SUNHL). Micromolar concentrations of sex steroids ex...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90381-6
更新日期:1994-01-30 00:00:00
abstract::We investigated the effects of the ethyl acetate extract of grapefruit juice (GFJ), that of orange juice (OJ) and their components on the uptake of [(3)H]vincristine into adriamycin-resistant human myelogenous leukemia cells. Its uptake was increased by the extracts of GFJ and OJ up to 7- and 3-fold, respectively, as ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00549-8
更新日期:2000-11-10 00:00:00
abstract::The effect of bile acids on the formation of azoxymethane induced aberrant crypt foci (ACF) was investigated using the fecal stream-excluded colons of colostomized F344 rats. The excluded colon was irrigated with saline or bile acids (1 mg/0.5 ml per day, 5 days/week) for 4 weeks. The mean numbers of ACF per colon in ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00525-0
更新日期:2001-08-28 00:00:00
abstract::BRCA1 regulates gene transcription as part of its tumor suppressor function. Prior studies on BRCA1 transactivation did not account for the impact of its binding partner, BARD1. Here we tested the effect of BARD1 on BRCA1 transactivation of the p21 and Gadd45 promoters. We show that BARD1 promoted nuclear accumulation...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.01.001
更新日期:2008-05-18 00:00:00
abstract::In the last year, several evidences indicated that pharmacological manipulation of relevant signaling pathways could selectively affect gene expression to influence cell fate. These findings render of extreme importance the elucidation of how external stimuli are transduced to mediate chromatin modifications, resultin...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2008.02.061
更新日期:2008-06-28 00:00:00
abstract::The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay. Topical applicatio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.11.014
更新日期:2005-06-28 00:00:00
abstract::We evaluated the ability of brain-derived neurotrophic factor (BDNF) to decrease the chemosensitivity of neuroblastoma cells to cisplatin. Two cell lines, one derived from SH-SY5Y (SY5Y-TB8) and the other from SK-N-AS (AS-TB8), transfected with a TrkB plasmid were generated, and used to assess the effects of activatio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00723-1
更新日期:2003-04-10 00:00:00
abstract::Birt-Hogg-Dubé (BHD) syndrome is a rare inherited genodermatosis characterized by benign hamartomatous skin lesions and an increased risk of pneumothorax and renal tumors. Many of the patients harbor insertion/deletion mutations in the hypermutable poly(C)(8) tract in exon 11 of the BHD gene. This mutational hot spot ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.06.005
更新日期:2007-04-08 00:00:00
abstract::Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.11.024
更新日期:2004-05-28 00:00:00
abstract::We have examined the expression of nitrotyrosine, a marker of peroxynitrite formation, in 55 esophageal cancers by immunohistochemistry. Nitrotyrosine was detected in 21 of 55 (38.2%) esophageal cancers. Comparison of nitrotyrosine expression and the pathological findings showed that there was a significant associatio...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00358-x
更新日期:2000-05-29 00:00:00
abstract::Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the genetic ablation or pharmacological inhibition of Ak...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.05.028
更新日期:2017-08-28 00:00:00
abstract::The South American opossum, Monodelphis domestica, has been used as a model system to study ultraviolet (UV)-induced genetic alterations that lead to the development of melanoma. Suckling young of Monodelphis exposed to multiple doses of UVB radiation can develop benign or malignant melanomas later as adults. Point mu...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00783-2
更新日期:2002-10-08 00:00:00
abstract::Up to a 50% rate of thyroid gland tumours was induced in Sprague-Dawley rats after s.c. administration of di-isopropanolnitrosamine (DIPN). The neoplasms occurred both unilaterally and bilaterally, and were identified histologically as adenomas and adenocarcinomas of follicular epithelium origin. In a few instances, a...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(77)80022-0
更新日期:1977-03-01 00:00:00
abstract::Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(99)00104-4
更新日期:1999-07-01 00:00:00
abstract::Pancreatic adenocarcinoma (PDAC) is associated with poor clinical outcomes and incomplete responses to conventional therapy. Therefore, there is an unmet clinical need to better understand the predisposing factors for pancreatic cancer in hopes of providing early screening to high-risk patients. While select risk fact...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.04.022
更新日期:2020-08-10 00:00:00
abstract::N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90053-1
更新日期:1980-10-01 00:00:00
abstract::B7-homolog 4 (B7-H4), a recently identified homolog of B7.1/2 (CD80/86), has been described to exert co-stimulatory and immune regulatory functions. We investigated the expression and the functional activity of B7-H4 in lung cancer in vitro and in vivo. Although a lung cancer cell line constitutively expressed B7-H4 m...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.11.017
更新日期:2012-04-01 00:00:00
abstract::Multidrug-resistant MCF-7 breast adenocarcinoma cells (originally named MCF-7/AdrR cells and later re-designated NCI/ADR-RES) have served as an important and widely used research tool during the last two decades. However, the real identity of these cells has been in doubt since 1998 and has since been debated. The ori...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.01.013
更新日期:2007-01-08 00:00:00
abstract::SENCAR mice have been selectively bred for hypersusceptibility to 2-stage chemical skin carcinogenesis. In this study the relative susceptibilities of SENCAR, BALB/c and CD-1 mice to systemic carcinogenesis by N-nitrosohexamethyleneimine (NHEX) were examined. NHEX was administered twice weekly (1 mg/mouse) in corn oil...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(88)90110-3
更新日期:1988-08-15 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest of all solid tumours and more effective therapy is urgently needed. The stroma is thought to play a critical role in tumour development and metastasis, and high stromal expression of the matricellular protein SPARC has been robustly associated with poor p...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.02.031
更新日期:2020-05-01 00:00:00
abstract::Prostate cancer urgently needs an efficient therapy. Here we demonstrated that cisplatin combined with gene therapy by transfecting the attenuated Salmonella that carry a plasmid containing p53 gene and MDM2 siRNA provided a super-synergistic effect on the inhibition of prostate cancer growth in vivo. This synergistic...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.05.028
更新日期:2013-08-28 00:00:00
abstract::Although patients with localized and regional kidney tumors have a high survival rate, incidence of mortality significantly increases for patients with metastatic disease. It is imperative to decipher the molecular mechanisms of kidney tumor migration and invasion in order to develop effective therapies for patients w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.022
更新日期:2012-07-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) is a transcriptional target and downstream effector of the ErbB-1 (EGFR) and ErbB-2 signaling pathways. We found that anti-EGFR and anti-ErbB-2 antibodies inhibited ERK phosphorylation and downregulated COX-2 protein expression in HCA-7 human colon carcinoma cells. Both antibodies also augment...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.11.020
更新日期:2007-06-28 00:00:00
abstract::Aberrant activation of mammalian target of rapamycin complex 1 (mTORC1), caused by loss or inactivation of TSC1/TSC2 protein complex, leads to negative feedback inhibition of Akt. The exact mechanisms of this process are still not fully understood. Here we present evidence for the involvement of STAT3, a known mTORC1 ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.09.006
更新日期:2011-12-27 00:00:00
abstract::Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.03.032
更新日期:2009-09-28 00:00:00
abstract::The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00230-4
更新日期:1998-11-27 00:00:00
abstract::Potassium bromate (KBrO(3)) is a rat renal carcinogen and a major drinking water disinfection by-product in water disinfected with ozone. Clear cell renal tumors, the most common form of human renal epithelial neoplasm, are rare in animals but are inducible by KBrO(3) in F344 rats. Detection of cytoplasmic periodic ac...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00407-x
更新日期:2002-12-10 00:00:00
abstract::This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.01.035
更新日期:2019-04-28 00:00:00
abstract::V600E being the most common mutation in BRAF, leads to constitutive activation of the MAPK signaling pathway. The majority of V600E BRAF positive melanoma patients treated with the BRAF inhibitor vemurafenib showed initial good clinical responses but relapsed due to acquired resistance to the drug. The aim of the pres...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.02.041
更新日期:2015-05-28 00:00:00
abstract::The renal handling of cisplatin was investigated in Sprague-Dawley rats in the presence and absence of probenecid and N'-methylnicotinamide. The renal clearance of free cisplatin was not significantly different from the glomerular filtration rate. N'-Methylnicotinamide, an organic cation, did not affect cisplatin clea...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90143-x
更新日期:1983-05-01 00:00:00