当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > Enhanced therapeutic effect of cisplatin on the prostate cancer in tumor-bearing mice by transfecting the attenuated Salmonella carrying a plasmid co-expressing p53 gene and mdm2 siRNA.

Enhanced therapeutic effect of cisplatin on the prostate cancer in tumor-bearing mice by transfecting the attenuated Salmonella carrying a plasmid co-expressing p53 gene and mdm2 siRNA.

Abstract：

:Prostate cancer urgently needs an efficient therapy. Here we demonstrated that cisplatin combined with gene therapy by transfecting the attenuated Salmonella that carry a plasmid containing p53 gene and MDM2 siRNA provided a super-synergistic effect on the inhibition of prostate cancer growth in vivo. This synergistic therapy was associated with the induction of apoptotic cell death with a decreased Bcl2 to Bax expression ratio and increased expression of cleaved caspase 3 and caspase 9 in the prostate cancer xenograft. These results indicate that cisplatin-chemotherapy in combination with targeting the MDM2/p53 axis is an attractive strategy to treat prostate cancer.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Jiang T,Zhou C,Gu J,Liu Y,Zhao L,Li W,Wang G,Li Y,Cai L

doi

10.1016/j.canlet.2013.05.028

subject

Has Abstract

pub_date

2013-08-28 00:00:00

pages

133-42

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(13)00414-X

journal_volume

337

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor.

    abstract：:It is known that hepatocyte growth factor binding to its receptor regulates gastric cancer progression and metastasis. HGF was found to up-regulate the expression of cyclooxygenase-2 gene and increases prostaglandin (PG) synthesis in gastric mucosa cells. Overexpression of COX-2 and increased PG secretion have also be...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.08.026

    authors： Chen JH,Wu CW,Kao HL,Chang HM,Li AF,Liu TY,Chi CW

    更新日期：2006-08-08 00:00:00

  • MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.

    abstract：:Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2. Here, we showed tha...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.11.002

    authors： Lv L,Li Y,Deng H,Zhang C,Pu Y,Qian L,Xiao J,Zhao W,Liu Q,Zhang D,Wang Y,Zhang H,He Y,Zhu J

    更新日期：2015-02-01 00:00:00

  • The role of des-gamma-carboxy prothrombin levels in hepatocellular carcinoma and liver tissues.

    abstract：:We aimed to clarify the clinical significance of des-gamma-carboxy prothrombin (DCP) levels in both hepatocellular carcinoma (HCC) and liver tissues with a special reference to the relationship between DCP level in non-cancerous parts of the liver and the multicentric occurrence of HCC. Twenty-eight patients with HCC,...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00539-5

    authors： Shimada M,Yamashita Y,Hamatsu T,Hasegawa H,Utsunomiya T,Aishima S,Sugimachi K

    更新日期：2000-10-16 00:00:00

  • Generation of cytotoxic monoclonals against AK-5 histiocytoma: conjugation with daunomycin and use in chemotherapy.

    abstract：:We have successfully generated cytotoxic monoclonal antibodies against a rat histiocytoma, AK-5. Monoclonal antibodies obtained after fusing immunized rat splenocytes with SP2/0 myeloma, were cytotoxic to AK-5 cells in the presence of complement. These monoclonals were highly specific and did not show any cross reacti...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90077-9

    authors： Khar A,Varalakshmi C,Pardhasaradhi BV,Ali AM

    更新日期：1992-06-15 00:00:00

  • Hypermethylation of the 5'CpG island of the FHIT gene in clear cell renal carcinomas.

    abstract：:FHIT is a tumour suppressor gene which is frequently inactivated in different types of cancer. Both genetic (mutations, deletions, chromosomal rearrangements) and epigenetic (aberrant methylation of the 5'CpG island) alterations of the FHIT gene have been reported in various malignancies. Yet little is known about the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.02.036

    authors： Kvasha S,Gordiyuk V,Kondratov A,Ugryn D,Zgonnyk YM,Rynditch AV,Vozianov AF

    更新日期：2008-07-08 00:00:00

  • Cloning of the rat proto-oncogene bmi-1.

    abstract：:The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00192-x

    authors： Osaka M,Koami K,Sugiyama T

    更新日期：1998-11-13 00:00:00

  • Disulfiram with or without metformin inhibits oesophageal squamous cell carcinoma in vivo.

    abstract：:Oesophageal squamous cell carcinoma (OSCC) is highly prevalent in developing countries but there has been little recent progress into efficacious yet affordable treatment strategies. Drug repurposing is one attractive approach for cancer therapy. Disulfiram (DSF), used to treat alcoholism, inhibits cancer growth and w...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2017.12.026

    authors： Jivan R,Peres J,Damelin LH,Wadee R,Veale RB,Prince S,Mavri-Damelin D

    更新日期：2018-03-28 00:00:00

  • Comparative reduction of 1-nitro-3-nitrosopyrene and 1-nitro-6-nitrosopyrene: implications for the tumorigenicity of dinitropyrenes.

    abstract：:Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90215-h

    authors： Djuric Z

    更新日期：1992-07-31 00:00:00

  • JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia.

    abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.07.025

    authors： Mulder SE,Dasgupta A,King RJ,Abrego J,Attri KS,Murthy D,Shukla SK,Singh PK

    更新日期：2020-10-28 00:00:00

  • Dose-response study of MeIQx carcinogenicity in F344 male rats.

    abstract：:The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90295-x

    authors： Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

    更新日期：1994-08-15 00:00:00

  • Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice.

    abstract：:In this study, we investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. 6BrCaQ has been previously identified as the most potent compound in a series of quinoleic novobiocin analogs but is poorly water-soluble. We investigated, for the first time, th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.06.001

    authors： Sauvage F,Fattal E,Al-Shaer W,Denis S,Brotin E,Denoyelle C,Blanc-Fournier C,Toussaint B,Messaoudi S,Alami M,Barratt G,Vergnaud-Gauduchon J

    更新日期：2018-09-28 00:00:00

  • Evidence for arylamine N-acetyltransferase in the nematode Anisakis simplex.

    abstract：:N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene were determined in Anisakis simplex, a nematode found in the intestine of the salt water fish Trichiurus lepturus. The N-acetyltransferase activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. The...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(96)04288-7

    authors： Chung JG,Kuo HM,Lin TH,Ho CC,Lee JH,Lai JM,Levy GN,Weber WW

    更新日期：1996-08-23 00:00:00

  • Flow cytometric DNA analysis and chromosomal aberrations in malignant glioblastomas.

    abstract：:In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(98)00383-8

    authors： Ehemann V,Hashemi B,Lange A,Otto HF

    更新日期：1999-04-26 00:00:00

  • Regulat-INGs in tumors and diseases: Focus on ncRNAs.

    abstract：:ING family genes (Inhibitor of Growth) are tumor suppressor genes that play a vital role in cell homeostasis. It has been shown that their expression is lost or diminished in many cancers and other diseases. The main mechanisms by which they are regulated in oncogenesis have not yet been fully elucidated. The involvem...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.01.006

    authors： Gournay M,Paineau M,Archambeau J,Pedeux R

    更新日期：2019-04-10 00:00:00

  • An in vitro model of pancreas carcinoma: N-nitroso-bis(2-hydroxypropyl)amine effects.

    abstract：:The carcinogenic effects of BHP in organ-cultured embryonic rat pancreas was demonstrated by both the transplacental route followed by organ culture and by direct addition on BHP to the culture medium. Both methods appeared efficient for in vitro induction of adenocarcinoma. The incidence of carcinoma was 70% by direc...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(80)90133-0

    authors： Parsa I,Marsh WH,Sutton AL

    更新日期：1980-03-01 00:00:00

  • Hepatocyte growth factor (HGF) upregulates heparanase expression via the PI3K/Akt/NF-κB signaling pathway for gastric cancer metastasis.

    abstract：:Heparanase (HPA) is an endoglucuronidase that can promote the shedding of associated cytokines in several types of tumors. However, little is known about what controls the expression of HPA or its role in gastric cancer. In this study, we report for the first time that HGF regulates HPA expression to promote gastric c...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.02.043

    authors： Hao NB,Tang B,Wang GZ,Xie R,Hu CJ,Wang SM,Wu YY,Liu E,Xie X,Yang SM

    更新日期：2015-05-28 00:00:00

  • RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.

    abstract：:We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hypothesised that by targeting...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.03.004

    authors： Walsh N,Larkin A,Swan N,Conlon K,Dowling P,McDermott R,Clynes M

    更新日期：2011-07-28 00:00:00

  • Abnormalities of retinoblastoma gene structure in human lung tumors.

    abstract：:The retinoblastoma (Rb) gene is associated with the pathogenesis of several types of human cancer, including retinoblastoma, osteosarcoma, soft tissue sarcomas, and lung, breast and bladder carcinomas. Loss of heterozygosity is a common mode in allelic inactivation of Rb and other tumor-suppressor genes. We investigat...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(93)90099-u

    authors： Linardopoulos S,Gonos ES,Spandidos DA

    更新日期：1993-07-30 00:00:00

  • Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells.

    abstract：:Digalloylresveratrol (DIG) is a new synthetic ester of the naturally occurring polyhydroxyphenolic substances gallic acid and resveratrol which both exert anti-cancer activity in a number of tumor cell lines. The aim of the study was to identify the biochemical effects of DIG in HT-29 human colon cancer cells. DIG ind...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.09.020

    authors： Bernhaus A,Fritzer-Szekeres M,Grusch M,Saiko P,Krupitza G,Venkateswarlu S,Trimurtulu G,Jaeger W,Szekeres T

    更新日期：2009-02-18 00:00:00

  • Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.

    abstract：:We examined the antitumor effect and safety of the adenovirus-mediated expression of antisense K-ras RNA in two peritoneal dissemination models of pancreatic cancer. First, we found that the infection of an adenovirus vector expressing antisense human K-ras RNA (AxCA-AS) induced significant apoptosis in vitro in human...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.08.015

    authors： Miura Y,Ohnami S,Yoshida K,Ohashi M,Nakano M,Ohnami S,Fukuhara M,Yanagi K,Matsushita A,Uchida E,Asaka M,Yoshida T,Aoki K

    更新日期：2005-01-31 00:00:00

  • Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines.

    abstract：:It has been proposed that a 356 amino acid protein encoded by the MIM (Missing In Metastasis) gene on Chromosome 8q24.1, is a bladder cancer metastasis suppressor. Recently, Machesky and colleagues [Biochem. J. 371 (2003) 463] identified MIM-B, a 759 amino acid protein, of which the C-terminal 356 amino acids are almo...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2004.05.002

    authors： Nixdorf S,Grimm MO,Loberg R,Marreiros A,Russell PJ,Pienta KJ,Jackson P

    更新日期：2004-11-25 00:00:00

  • Concomitant DDX1 and MYCN gain in neuroblastoma.

    abstract：:DDX1, a gene mapping to the 2p24 region, has been observed to be co-amplified with MYCN in neuroblastoma. Co-amplification of the DDX1 gene is a consequence of the short physical distance between the two genes. Recently, it has been found that neuroblastoma cells can show a low increase in MYCN gene copy number, defin...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.05.010

    authors： Defferrari R,Tonini GP,Conte M,Papio F,Sementa AR,Valent A,Schena F,Perri P,Mazzocco K

    更新日期：2007-10-18 00:00:00

  • Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid.

    abstract：:Glycyrrhetic acid is an anti-inflammatory agent isolated from licorice root that inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated tumor promotion in mouse skin. Although it has been established that glycyrrhetic acid inhibits a number of events induced by the phorbol ester tumor promoter TPA in cultured ce...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(90)90132-h

    authors： O'Brian CA,Ward NE,Vogel VG

    更新日期：1990-01-01 00:00:00

  • Interleukin-6 level in patients with colorectal cancer.

    abstract：:Interleukin-6 (IL-6) contributes to a multitude of physiological and pathophysiological processes. We sought to determine the level of the IL-6 in serum and tumoral tissue of patients with staging of the tumor and whether serum IL-6 level in patients with colorectal cancer correlate with tumoral tissue level of it. Se...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.12.003

    authors： Esfandi F,Mohammadzadeh Ghobadloo S,Basati G

    更新日期：2006-11-28 00:00:00

  • High-LET radiation combined with oxaliplatin induce autophagy in U-87 glioblastoma cells.

    abstract：:Modern protocols of concomitant chemo/radiotherapy provide a very effective strategy to treat certain types of tumors. High-linear energy transfer (LET) radiations, on the other hand, have an increased efficacy against cancer with low radiosensibility and critical localization. We previously reported that oxaliplatin,...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2008.01.023

    authors： Benzina S,Altmeyer A,Malek F,Dufour P,Denis JM,Gueulette J,Bischoff P

    更新日期：2008-06-08 00:00:00

  • Inhibition of GSH synthesis potentiates temozolomide-induced bystander effect in glioblastoma.

    abstract：:Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. However, GBM patients exhibit various levels of the elevated expression of...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2012.12.005

    authors： Kohsaka S,Takahashi K,Wang L,Tanino M,Kimura T,Nishihara H,Tanaka S

    更新日期：2013-04-30 00:00:00

  • Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori.

    abstract：:In Mongolian gerbils, the gastric mucosa shows dramatic changes after Helicobacter pylori inoculation. The influence of the timing of N-methyl-N-nitrosourea (MNU) administration after H. pylori inoculation on gastric carcinogenesis was investigated. Ninety-two gerbils were divided into four groups. One group was given...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00571-1

    authors： Maruta F,Sugiyama A,Ishida K,Ikeno T,Murakami M,Kawasaki S,Ota H,Tatematsu M,Katsuyama T

    更新日期：2000-11-10 00:00:00

  • Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P).

    abstract：:In a development trial for an initiation bioassay system, cell proliferation kinetics after partial hepatectomy (PH) or CCl4 administration (1 ml/kg b.w., i.g.) and the effect of administration time after PH or CCl4 treatment on liver cell foci induction by the direct and indirect non-hepatocarcinogens, N-methyl-N'-ni...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(97)00222-x

    authors： Kobayashi K,Mutai M,Goto K,Inada K,Tsukamoto T,Nakanishi H,Tatematsu M

    更新日期：1997-09-16 00:00:00

  • Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

    abstract：:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.04.040

    authors： Lee WY,Liu KW,Yeung JH

    更新日期：2009-11-18 00:00:00

  • Targeted therapy for hepatocellular carcinoma: Challenges and opportunities.

    abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.114428

    authors： Chen S,Cao Q,Wen W,Wang H

    更新日期：2019-09-28 00:00:00