Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice.

abstract：:We conducted a pilot study to assess the feasibility using the Electoral Register to carry out a cervical cancer screening programme on a Health District basis. A random sample of 500 names and addresses were drawn from a computerised list of the Electoral Register from three Electoral Wards in Oxford. A pilot study s...

journal_title：Cancer letters

authors： Cook GA,Wald NJ

更新日期：1985-09-30 00:00:00

abstract：:Two-month-old outbred female LIO rats were exposed weekly to 15 (experiment I, groups 1, 2 and 3) or to 5 (experiment II, groups 4, 5 and 6) subcutaneous injections of 1,2-dimethylhydrazine (DMH) at a single dose of 21 mg/kg of body weight. From the day of the first injection of the carcinogen, the rats from groups 2,...

journal_title：Cancer letters

authors： Anisimov VN,Zabezhinski MA,Popovich IG,Berstein LM,Kovalenko IG,Lieberman AI,Shmidt JL

更新日期：1999-04-26 00:00:00

abstract：:Since CP always exists in aqueous solution as a mixture of native drug and various aqua and hydroxo species, it is conceivable that one or more of these aquated species is the main form of the drug that enters the cell. To test this hypothesis, we examined the accumulation by 2008 human ovarian carcinoma cells of CP a...

journal_title：Cancer letters

authors： Jennerwein M,Andrews PA

更新日期：1994-06-30 00:00:00

abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...

journal_title：Cancer letters

authors： Zhao Q,Yu X,Li M,Liu Y,Han Y,Zhang X,Li XM,Wu X,Qin J,Fang J,Zhang H

更新日期：2019-09-10 00:00:00

abstract：:N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human...

journal_title：Cancer letters

authors： Runge RG,Pour P

更新日期：1980-10-01 00:00:00

abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

journal_title：Cancer letters

authors： Bogovski P,Day N

更新日期：1977-07-01 00:00:00

abstract：:Major cytotoxic components were fractionated from Korean mistletoe and the changes of their cytotoxic effects caused by heat treatment were investigated. The high cytotoxicity of isolated lectin I completely disappeared by heating for 30 min. The fractions of viscotoxins and alkaloids maintained their activities even ...

journal_title：Cancer letters

authors： Park JH,Hyun CK,Shin HK

更新日期：1999-05-24 00:00:00

abstract：:The kinase insert domain-containing receptor (KDR) is the human vascular endothelial growth factor (VEGF) receptor responsible for the mitogenic and angiogenic effects of VEGF. There is much experimental evidence to suggest that the VEGF/KDR pathway plays an important role in tumor angiogenesis, a process essential fo...

journal_title：Cancer letters

authors： Zhu Z,Lu D,Kotanides H,Santiago A,Jimenez X,Simcox T,Hicklin DJ,Bohlen P,Witte L

更新日期：1999-03-01 00:00:00

abstract：:We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of...

journal_title：Cancer letters

authors： Gao H,Peng C,Liang B,Shahbaz M,Liu S,Wang B,Sun Q,Niu Z,Niu W,Liu E,Wang J,Lin P,Wang J,Niu J

更新日期：2014-11-28 00:00:00

abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

journal_title：Cancer letters

authors： Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

更新日期：2018-07-01 00:00:00

abstract：:It is widely known that dietary lipids can modify the ability of different cancers to grow up and metastasize, especially mammary gland tumors. However, it is still unclear whether n-6 fatty acids behave as tumor promoters in this gland cell population. The effect of different nutritional polyunsaturated fatty acids (...

journal_title：Cancer letters

authors： Muñoz SE,Lopez CB,Valentich MA,Eynard AR

更新日期：1998-04-24 00:00:00

abstract：:The ability of the cytosolic arylamine oxidase to convert structurally diverse aromatic and heterocyclic amines to mutagens in the Ames test was investigated using hepatic cytosol from Aroclor 1254-treated rats as the activation system. Using this system, only amino compounds containing at least three fused aromatic r...

journal_title：Cancer letters

authors： Marczylo T,Ioannides C

更新日期：1998-05-15 00:00:00

abstract：:Breast fluid which bathes the mammary ductal epithelium may contain tumorogenic components. In view of the number of tobacco components inhaled during smoking, it was of interest whether nicotine and its metabolites were present in this fluid. Fluid was obtained from the nipple from menstruating women who were smokers...

journal_title：Cancer letters

authors： Hill P,Wynder EL

更新日期：1979-04-01 00:00:00

abstract：:Although Apc(Min/+) mice are widely used for an animal model of human familial adenomatous polyposis (FAP), a majority of intestinal polyps locate in the small intestine. We recently reported that numerous beta-catenin-accumulated crypts (BCAC), which are reliable precursor lesions for colonic adenocarcinoma, develop ...

journal_title：Cancer letters

authors： Hata K,Tanaka T,Kohno H,Suzuki R,Qiang SH,Yamada Y,Oyama T,Kuno T,Hirose Y,Hara A,Mori H

更新日期：2006-07-28 00:00:00

abstract：:To date, several kinds of immunomodulating monoclonal antibodies (mAbs) have been applied in clinical trials, such as anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) mAb and anti-programmed death-1 (anti-PD-1) mAb. With the recent success of cancer immunotherapy, especially the checkpoint inhibitors, the renewed i...

journal_title：Cancer letters

authors： Teng F,Kong L,Meng X,Yang J,Yu J

更新日期：2015-08-28 00:00:00

abstract：:The effects of vitamin E, vitamin B2 and selenite on DNA single strand breaks induced by Na2CrO4 were examined by alkaline elution. Incubation of Chinese hamster V-79 cells with alpha-tocopherol succinate (vitamin E) for 24 h prior to exposure to Na2CrO4 resulted in a decrease of DNA breaks produced by this compound. ...

journal_title：Cancer letters

authors： Sugiyama M,Ando A,Furuno A,Furlong NB,Hidaka T,Ogura R

更新日期：1987-12-01 00:00:00

abstract：:Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect sandwich enzyme-linked immunoso...

journal_title：Cancer letters

authors： Tu M,Lu C,Lv N,Wei J,Lu Z,Xi C,Chen J,Guo F,Jiang K,Li Q,Wu J,Song G,Wang S,Gao W,Miao Y

更新日期：2016-12-28 00:00:00

abstract：:Angiogenesis is regulated by numerous "classic" factors such as vascular endothelial growth factor (VEGF) and many other endogenous "non-classic"peptides, including erythropoietin (Epo), and granulocyte-/granulocyte macrophage colony stimulating factor (G-/GM-CSF). The latter play an important regulatory role in angio...

journal_title：Cancer letters

authors： Ribatti D,Tamma R

更新日期：2019-01-01 00:00:00

abstract：:Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) pro...

journal_title：Cancer letters

authors： Paschka AG,Butler R,Young CY

更新日期：1998-08-14 00:00:00

abstract：:The B cell lymphomas associated with Epstein-Barr virus (EBV) are not limited to any specific stage of B cell differentiation but covers widely different B cell phenotypes. In vitro infection of the virus negative tumors with a recombinant EBV strain has provided important insights into virus-tumor interaction. Here, ...

journal_title：Cancer letters

authors： Anastasiadou E,Vaeth S,Cuomo L,Boccellato F,Vincenti S,Cirone M,Presutti C,Junker S,Winberg G,Frati L,Wade PA,Faggioni A,Trivedi P

更新日期：2009-11-01 00:00:00

abstract：:Gastric cancers with and those without high-frequency microsatellite instability (MSI-H) represent distinctive pathways of carcinogenesis. The aim of this study was to clarify if expression of p53 related genes involved in angiogenesis is differentially regulated between these cancers. We systematically analyzed the e...

journal_title：Cancer letters

authors： Miyamoto N,Yamamoto H,Taniguchi H,Miyamoto C,Oki M,Adachi Y,Imai K,Shinomura Y

更新日期：2007-08-28 00:00:00

abstract：:Macrophages that infiltrate tumor tissues, or tumor-associated macrophages (TAMs), affect the malignant behaviors of tumor cells. In this study, we attempted to induce monocytes to differentiate into TAM-like cells producing matrix metalloproteinases (MMPs) by co-culture with tumor cells. When human monocytes were co-...

journal_title：Cancer letters

authors： Kamoshida G,Matsuda A,Sekine W,Mizuno H,Oku T,Itoh S,Irimura T,Tsuji T

更新日期：2012-02-28 00:00:00

abstract：:Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...

journal_title：Cancer letters

authors： Xu Z,Wang Z,Jia X,Wang L,Chen Z,Wang S,Wang M,Zhang J,Wu M

更新日期：2016-03-01 00:00:00

abstract：:EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (...

journal_title：Cancer letters

authors： Zhang L,Peng S,Dai X,Gan W,Nie X,Wei W,Hu G,Guo J

更新日期：2017-04-01 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Cancer cells are shed into the blood stream and are exposed to hemodynamic shear stress during metastasis. It has been shown that shear stress can destroy circulating tumor cells (CTCs) both in vitro and in vivo. However, it remains unclear whether shear stress can modulate the properties and functions of tumor cells ...

journal_title：Cancer letters

authors： Ma S,Fu A,Chiew GG,Luo KQ

更新日期：2017-03-01 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:Current limitation in cancer genomic studies is a lack of the integration of various omics data generated through next generation sequencing technologies, as well as a lack of the sounding and comprehensive epigenomic and genomic information about a particular cancer cell type. In this review, we will discuss main asp...

journal_title：Cancer letters

authors： Tang B,Hsu PY,Huang TH,Jin VX

更新日期：2013-11-01 00:00:00

abstract：:The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...

journal_title：Cancer letters

authors： Iida K,Yamamoto M,Kato M,Yoshida K,Kurita K,Tatematsu M

更新日期：1999-01-29 00:00:00

abstract：:Cell kinetics (cell proliferation and cell death) and the expression of progesterone receptor (PgR) during growth and regression of pregnancy-dependent mammary tumors (PDMT) of female GRS/A mice were investigated on the histologic level. Cell proliferation was determined using monoclonal anti-proliferating cell nuclea...

journal_title：Cancer letters

authors： Yang J,Senzaki H,Nambu H,Tsubura A

更新日期：1996-08-23 00:00:00