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Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate.

Abstract：

:Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigallocatechin-3-gallate (EGCG) proved to be the most potent catechin at inhibiting cell growth. The inhibition induced by EGCG was found to occur via apoptotic cell death as shown by changes in nuclear morphology and DNA fragmentation. Thus, we report the first evidence that EGCG is the active component in green tea and induces apoptosis in human prostate cancer cells.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Paschka AG,Butler R,Young CY

doi

10.1016/s0304-3835(98)00084-6

subject

Has Abstract

pub_date

1998-08-14 00:00:00

pages

1-7

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(98)00084-6

journal_volume

130

pub_type

杂志文章

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