Activation of NFkB is a novel mechanism of pro-survival activity of glucocorticoids in breast cancer cells.

abstract：:We generated three anti-ErbB-2 monoclonal antibodies (mAbs) by using surface-epitope masking method (SEM method). They were characterized and shown to recognize the extracellular domain (ECD) of ErbB-2 specifically. In order to detect ErbB-2 in the sera of breast cancer patients, we used two of them: A18 and A21 to de...

journal_title：Cancer letters

authors： Li P,Li Y,Li JY,Liu J

更新日期：2003-04-25 00:00:00

abstract：:As a newly discovered deubiquitinating enzyme, ubiquitin-specific protease 22 (USP22) is predictive of therapeutic outcomes in individual cancer patients. However, its clinical effects on malignancy and its roles in conferring resistance to EGFR-TKIs (epidermal growth factor receptor-tyrosine kinase inhibitors) in lun...

journal_title：Cancer letters

authors： Zhang H,Han B,Lu H,Zhao Y,Chen X,Meng Q,Cao M,Cai L,Hu J

更新日期：2018-10-01 00:00:00

abstract：:Cancer stem cells are known for their inherent resistance to therapy. Here we investigated whether normal stem cells with acquired resistance to stress can be used to identify novel markers of cancer stem cells. For this, we generated a human embryonic stem cell line resistant to Trichostatin A and analyzed changes in...

journal_title：Cancer letters

authors： Mousa SA,Sudha T,Dyskin E,Dier U,Gallati C,Hanko C,Chittur SV,Rebbaa A

更新日期：2010-03-28 00:00:00

abstract：:Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1 treated rats. Quercetin and kaempferol inhibited the enzyme activity of all these fractions at very low dose levels. The...

journal_title：Cancer letters

authors： Mistry KJ,Krishna M,Bhattacharya RK

更新日期：1997-12-16 00:00:00

abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...

journal_title：Cancer letters

authors： Munagala R,Aqil F,Jeyabalan J,Gupta RC

更新日期：2016-02-01 00:00:00

abstract：:Oesophageal cancer is associated with high morbidity and mortality rates because it is highly invasive and prone to recurrence and metastasis, with a five-year survival rate of <20%. Therefore, there is an urgent need for new methods aimed at improving therapeutic intervention. Several studies have shown that targeted...

journal_title：Cancer letters

authors： Zhang Y,Liu S,Zhou S,Yu D,Gu J,Qin Q,Cheng Y,Sun X

更新日期：2021-01-01 00:00:00

abstract：:The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...

journal_title：Cancer letters

authors： Rosenblum D,Peer D

更新日期：2014-09-28 00:00:00

abstract：:The role of reactive oxygen species (ROS) and p38 mitogen-activated protein kinases (MAPK) in tanshinones-induced apoptosis was investigated in HepG2 cells in this study. The major tanshinones (cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA), isolated from Salvia miltiorrhiza, inhibit cell growth an...

journal_title：Cancer letters

authors： Lee WY,Liu KW,Yeung JH

更新日期：2009-11-18 00:00:00

abstract：:Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the beha...

journal_title：Cancer letters

authors： Wu Q,Liu W,Wang J,Zhu L,Wang Z,Peng Y

更新日期：2020-11-28 00:00:00

abstract：:Telomerase activity (TA) and telomerase reverse transcriptase (rTERT) were investigated in Sprague-Dawley rats, killed at 6 and 12 h, and 1, 2, 3, 7, and 14 days after 90% pancreatectomy (px), by TRAPeze enzyme-linked immunosorbent assay telomerase detection and reverse transcriptase-polymerase chain reaction. TA incr...

journal_title：Cancer letters

authors： Oh BK,Seong JK,Lee JE,Chae KJ,Roh KJ,Park C,Park YN

更新日期：2002-12-01 00:00:00

abstract：:The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...

journal_title：Cancer letters

authors： Zhang T,Zheng J,Jiang N,Wang G,Shi Q,Liu C,Lu Y

更新日期：2009-09-28 00:00:00

abstract：:Since angiogenesis is considered essential for tumor growth and the development of metastasis, we assessed the correlation of microvessel density (MVD) with overall survival in patients with epithelial ovarian cancer. Histologic slides were immunostained for CD34-antigen. MVD was determined within each tumor by enumer...

journal_title：Cancer letters

authors： Obermair A,Wasicky R,Kaider A,Preyer O,Lösch A,Leodolter S,Kölbl H

更新日期：1999-04-26 00:00:00

abstract：:Cap-mediated translation is the default mechanism for the synthesis of proteins in eukaryotic cells. Increasingly, malignant cells have been found to have deregulation of this process. Return of normal translational control is associated with loss of tumorigenic potential in pre-clinical models. Currently, a variety o...

journal_title：Cancer letters

authors： Thumma SC,Kratzke RA

更新日期：2007-12-08 00:00:00

abstract：:NLRC5, the largest member of nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family, has been reported to regulate immune responses and is associated with chronic inflammatory diseases. However, the biological function of NLRC5 in hepatocellular carcinoma (HCC) has not yet been well demonstrate...

journal_title：Cancer letters

authors： Peng YY,He YH,Chen C,Xu T,Li L,Ni MM,Meng XM,Huang C,Li J

更新日期：2016-06-28 00:00:00

abstract：:The DR5/TRAIL receptor 2 gene is a novel TNF receptor family member and induces apoptosis by overexpression of its product. DR5 is located on chromosome 8p21, where allelic deletions are often observed in advanced colorectal cancers. This evidence led us to examine whether or not mutations of the DR5 gene exist in the...

journal_title：Cancer letters

authors： Arai T,Akiyama Y,Okabe S,Saito K,Iwai T,Yuasa Y

更新日期：1998-11-27 00:00:00

abstract：:Previous studies had established that transforming growth factor-beta1 (TGF-beta1) is highly expressed in bladder tumor, facilitating progression and spreading of the cancerous cells. Here, we report that both the number and the cytotoxic function of natural killer (NK) cells are decreased in patients with superficial...

journal_title：Cancer letters

authors： Lin CT,Yu MT,Li C,Ho YC,Shen CH,Liu DW,Chang DC,Wu SF

更新日期：2010-05-01 00:00:00

abstract：:Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have served as biomarkers that distinguish brain tumor origin and malignancy. I...

journal_title：Cancer letters

authors： Seyfried NT,Huysentruyt LC,Atwood JA 3rd,Xia Q,Seyfried TN,Orlando R

更新日期：2008-05-18 00:00:00

abstract：:The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and t...

journal_title：Cancer letters

authors： Tamatani T,Azuma M,Aota K,Yamashita T,Bando T,Sato M

更新日期：2001-10-10 00:00:00

abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

journal_title：Cancer letters

authors： Zhang HY,Sun H

更新日期：2010-01-01 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:We describe the events triggered by a sub-lethal concentration of airborne particulate matter (PM(10)) in A549 cells, which include the formation DNA double-strand breaks, gammaH2A.X generation, and 53BP1 recruitment. To protect the genome, cells activated ATM/ATR/Chk1/Chk2/p53 pathway but, after 48 h, cells turned in...

journal_title：Cancer letters

authors： Sánchez-Pérez Y,Chirino YI,Osornio-Vargas ÁR,Morales-Bárcenas R,Gutiérrez-Ruíz C,Vázquez-López I,García-Cuellar CM

更新日期：2009-06-18 00:00:00

abstract：:Radiation therapy has become an important tool in the treatment of cancer patients, but most patients relapse within 5 years. Relapse is due to the presence of cancer stem cells (CSCs), but the molecular mechanism of radioresistance in CSCs remains largely elusive. Here, we found that irradiation-resistant (IR) cells ...

journal_title：Cancer letters

authors： Shi Y,Liu N,Lai W,Yan B,Chen L,Liu S,Liu S,Wang X,Xiao D,Liu X,Mao C,Jiang Y,Jia J,Liu Y,Yang R,Cao Y,Tao Y

更新日期：2018-05-28 00:00:00

abstract：:Tumor promoters such as phorbol esters, teleocidin and okadaic acid increase the numbers of multilayered, transformed foci produced by BPV DNA-transfected C3H/10T1/2 cells. We questioned whether arsenic and chromium, which are known human carcinogens also enhance transformation of BPV DNA-transfected C3H/10T1/2 cells....

journal_title：Cancer letters

authors： Kowalski LA,Tsang SS,Davison AJ

更新日期：1996-05-15 00:00:00

abstract：:Mining and mineral processing are important industries in the United States. A large number of workers are potentially exposed to silica during mining and to glass fibers during manufacturing. There is a concern regarding lung cancer risk among workers exposed to silica and glass fibers. Our previous studies showed th...

journal_title：Cancer letters

authors： Gao H,Brick J,Ong S,Miller M,Whong WZ,Ong T

更新日期：1997-01-15 00:00:00

abstract：:The age-standardized mortality rates by sex for cancer of all sites and some specific sites were calculated in the 22 areas of Rosario (Argentina). The rates by area were correlated with education, occupation, housing quality and population density, applying Kendall's tau. Cervical cancer rates showed the strongest co...

journal_title：Cancer letters

authors： Poletto L,Morini JC

更新日期：1990-03-01 00:00:00

abstract：:Patients with inadequate anti-cancer T cell responses experience limited benefit from immune checkpoint inhibitors and other immunotherapies that require T cells. Therefore, treatments that induce de novo anti-cancer T cell immunity are needed. One strategy - referred to as in situ vaccination - is to deliver chemothe...

journal_title：Cancer letters

authors： Lynn GM,Laga R,Jewell CM

更新日期：2019-09-10 00:00:00

abstract：:The in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-...

journal_title：Cancer letters

authors： Pal K,Grover PL,Sims P

更新日期：1979-06-01 00:00:00

abstract：:R-spondins play critical roles in development, stem cell survival, and tumorigenicity by modulating Wnt/β-catenin signaling; however, the role of R-spondins in noncanonical Wnt signaling regulation remains largely unknown. We demonstrate here that R-spondin 2 (RSPO2) has an inhibitory effect on colorectal cancer (CRC)...

journal_title：Cancer letters

authors： Dong X,Liao W,Zhang L,Tu X,Hu J,Chen T,Dai X,Xiong Y,Liang W,Ding C,Liu R,Dai J,Wang O,Lu L,Lu X

更新日期：2017-08-28 00:00:00

abstract：:Pancreatic cancer remains a highly lethal malignancy. We have recently shown that simultaneous expression of Kras and mutant Tp53R175H promotes invasive ductal adenocarcinoma from pancreatic ductal cells. We hypothesized specific mutations in TP53 have divergent mechanisms of transforming ductal cells. In order to und...

journal_title：Cancer letters

authors： Polireddy K,Singh K,Pruski M,Jones NC,Manisundaram NV,Ponnela P,Ouellette M,Van Buren G,Younes M,Bynon JS,Dar WA,Bailey JM

更新日期：2019-07-01 00:00:00

abstract：:Standard chemotherapeutic protocols, based on maximum tolerated doses, do not prevent nor overcome chemoresistance caused by the efflux transporter P-glycoprotein (Pgp). We compared the effects of two consecutive low doses versus a single high dose of doxorubicin in drug-sensitive Pgp-negative and drug-resistant Pgp-p...

journal_title：Cancer letters

authors： Riganti C,Gazzano E,Gulino GR,Volante M,Ghigo D,Kopecka J

更新日期：2015-05-01 00:00:00