Exosomal noncoding RNAs in colorectal cancer.

abstract：:Nitric oxide synthase (NOS), an important bioregulator of a variety of biological processes, is overexpressed in colonic tumors of humans and rodents. In this study, effects of L-N(G)-nitroarginine methyl ester (L-NAME), a NOS inhibitor, on development of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in F344...

journal_title：Cancer letters

authors： Kawamori T,Takahashi M,Watanabe K,Ohta T,Nakatsugi S,Sugimura T,Wakabayashi K

更新日期：2000-01-01 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies. Here, the anti-inflammatory and anti-tumor effects of embelin on pancreatic cancer were investigated. Embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of STAT3 and activ...

journal_title：Cancer letters

authors： Peng M,Huang B,Zhang Q,Fu S,Wang D,Cheng X,Wu X,Xue Z,Zhang L,Zhang D,Da Y,Dai Y,Yang Q,Yao Z,Qiao L,Zhang R

更新日期：2014-11-28 00:00:00

abstract：:Transendothelial migration (TEM) of tumor cells is a crucial step in metastasis formation. The prevailing paradigm is that the mechanism underlying TEM of tumor cells is similar to that of leukocytes involving adhesion molecules and chemokines. Fractalkine (CX3CL1) is a unique membrane-bound chemokine that functions a...

journal_title：Cancer letters

authors： Nevo I,Sagi-Assif O,Meshel T,Ben-Baruch A,Jöhrer K,Greil R,Trejo LE,Kharenko O,Feinmesser M,Yron I,Witz IP

更新日期：2009-01-08 00:00:00

abstract：:The scope of the structure-anticancer activity relationship among various aliphatic and aromatic hydrazones containing the N,N,N',N'-bis(1,2-ethanediyl)-phosphoric diamide moiety was studied. A total of 19 compounds were tested in vivo, using murine lymphocytic leukemia P388. At optimum dose all these compounds were a...

journal_title：Cancer letters

authors： Sosnovsky G,Rao NU

更新日期：1985-12-01 00:00:00

abstract：:The present study was conducted to clarify the mechanism responsible for enhancement of the anti-melanoma activity of levodopa methylester by supplemental ascorbate in vivo. 5-Hydroxydopa, a known cytotoxic agent and the major metabolite formed from levodopa in the presence of ascorbate and mushroom tyrosinase in vitr...

journal_title：Cancer letters

authors： Pierson HF,Meadows GG

更新日期：1985-11-01 00:00:00

abstract：:Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...

journal_title：Cancer letters

authors： Takasuka N,Takahashi M,Hori Y,Kitahashi T,Iigo M,Imai T,Yoshimi N,Sugimura T,Wakabayashi K

更新日期：2009-03-08 00:00:00

abstract：:The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs). Limited evidence indicated that it was also expressed in tissues other than thymus and spleen, while, very recently, it was identified as a suppressor gene in breast cancer. However, ...

journal_title：Cancer letters

authors： Zhang HY,Sun H

更新日期：2010-01-01 00:00:00

abstract：:The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repe...

journal_title：Cancer letters

authors： Hong SK,Park JR,Kwon OS,Kim KT,Bae GY,Cha HJ

更新日期：2016-07-01 00:00:00

abstract：:Bevacizumab (Avastin®, Genentech, CA) was granted accelerated approval by the FDA for metastatic breast cancer in 2008. This occurred after the initial clinical trial, E2100, demonstrated an improvement in progression-free survival (PFS) and overall survival (OS) with the addition of bevacizumab to a standard chemothe...

journal_title：Cancer letters

authors： Afranie-Sakyi JA,Klement GL

更新日期：2015-02-01 00:00:00

abstract：:Inhibition of DNA synthesis was observed and quantitated in hamster buccal pouch epithelium exposed in vivo and in vitro to indirect acting carcinogens. Topical application of a 0.5% solution of the potent hamster buccal pouch carcinogen 7,12-dimethylbenz[a]-anthracene (DMBA) acutely inhibited epithelial DNA synthesis...

journal_title：Cancer letters

authors： Nagabhushan M,Ng YK,Elias R,Polverini PJ,Solt DB

更新日期：1990-09-01 00:00:00

abstract：:The acute intraperitoneal toxicities of chlorambucil and chlorambucil-spermidine conjugate have been compared, in mice. Both compounds were neurotoxic and also caused a prolonged fall in bodyweight and a depletion of lymphocyte numbers associated with a fall in the total leukocyte count and loss of spleen and thymus w...

journal_title：Cancer letters

authors： Verschoyle RD,Carthew P,Holley JL,Cullis P,Cohen GM

更新日期：1994-10-14 00:00:00

abstract：:Vasohibin 2 (VASH2) is an angiogenic factor and cancer-related protein that acts via paracrine mechanisms. Here, we investigated the angiogenic function and mechanism of action of VASH2 in 200 human breast cancer tissues by performing immunohistochemical staining, western blot, indirect sandwich enzyme-linked immunoso...

journal_title：Cancer letters

authors： Tu M,Lu C,Lv N,Wei J,Lu Z,Xi C,Chen J,Guo F,Jiang K,Li Q,Wu J,Song G,Wang S,Gao W,Miao Y

更新日期：2016-12-28 00:00:00

abstract：:The stem cell-like characteristics of tumor cells are not only essential for tumor development and malignant progression, but also significantly contribute to therapy resistance. However, it remains poorly understood how cancer cell differentiation or stemness is regulated in vivo. We investigated the role of the stem...

journal_title：Cancer letters

authors： Begum A,Kim Y,Lin Q,Yun Z

更新日期：2012-05-01 00:00:00

abstract：:Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. Therefore, the rationale for this study is that this gene could also be implicated in breast pathogenesis as well. We investigated allelic losses in microsatellites of the...

journal_title：Cancer letters

authors： Leighton X,Srikantan V,Pollard HB,Sukumar S,Srivastava M

更新日期：2004-07-16 00:00:00

abstract：:The polymorphism in the ALDH2 gene plays a central role in Asian alcohol hypersensitivity and has been associated with the risk for esophageal cancer. In the present study, we attempted to examine associations between the ADH2 and ALDH2 polymorphisms, alcohol drinking and hepatocellular carcinoma (HCC) development in ...

journal_title：Cancer letters

authors： Takeshita T,Yang X,Inoue Y,Sato S,Morimoto K

更新日期：2000-02-28 00:00:00

abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...

journal_title：Cancer letters

authors： Liu R,Wei S,Chen J,Xu S

更新日期：2014-10-28 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...

journal_title：Cancer letters

authors： Tanabe A,Tanikawa K,Tsunetomi M,Takai K,Ikeda H,Konno J,Torigoe T,Maeda H,Kutomi G,Okita K,Mori M,Sahara H

更新日期：2016-06-28 00:00:00

abstract：:Human microsomal epoxide hydrolase (mEH) catalyzes a key step in the biotransformation of benzo[a]pyrene that yields the highly mutagenic (+)-anti-7,8-diol-9,10 epoxide (BPDE). Two polymorphisms have been described in the coding region of the mEH gene (EPHX1) that produce two protein variants: 113Tyr-->113His (exon 3)...

journal_title：Cancer letters

authors： To-Figueras J,Gené M,Gómez-Catalán J,Piqué E,Borrego N,Corbella J

更新日期：2001-11-28 00:00:00

abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

journal_title：Cancer letters

authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

更新日期：2009-11-01 00:00:00

abstract：:The development of multidrug resistance (MDR) to chemotherapy remains a major challenge in the treatment of cancer. Numerous mechanisms have been recognized that cause MDR, but one of the most important mechanisms is overexpression of adenosine triphosphate (ATP)-binding cassette (ABC) transporters, through which the ...

journal_title：Cancer letters

authors： Fan YF,Zhang W,Zeng L,Lei ZN,Cai CY,Gupta P,Yang DH,Cui Q,Qin ZD,Chen ZS,Trombetta LD

更新日期：2018-05-01 00:00:00

abstract：:The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...

journal_title：Cancer letters

authors： Hong W,Dong E

更新日期：2014-08-28 00:00:00

abstract：:To address the possible involvement of hyperinsulinemia in breast cancer development, we have examined the susceptibility of lean and obese Zucker rats to N-methyl-N-nitrosourea (MNU)-induced mammary cancer. Fifty-day-old female lean or obese Zucker rats received intraperitoneal (i.p.) injections of 37.5 or 20 mg/kg M...

journal_title：Cancer letters

authors： Lee WM,Lu S,Medline A,Archer MC

更新日期：2001-01-26 00:00:00

abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

journal_title：Cancer letters

authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

更新日期：2014-05-28 00:00:00

abstract：:Cancer prevention techniques include legislative regulation, chemoprevention, adherence to a "healthful" lifestyle, and specialized medical intervention. Attempts at cancer prevention have possibly avoided a dramatic increase in cancer incidence and mortality due to increasing dependence on the products of the chemica...

journal_title：Cancer letters

authors： Clayson DB

更新日期：1990-04-09 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

journal_title：Cancer letters

authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

更新日期：2007-02-08 00:00:00

abstract：:A 1-week treatment with the hepatocarcinogen beta-blocker DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305) induces the appearance of preneoplastic liver lesions--oval cell hyperplasia, basophilic and gamma-glutamyltranspeptidase positive (GGT+) foci--in female Wistar rats, as evidenced by the ...

journal_title：Cancer letters

authors： Zavanella T,Presta M,Braga G,Dimito E,Mazzocchi C,Ziliani S,Ragnotti G

更新日期：1984-11-01 00:00:00

abstract：:The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...

journal_title：Cancer letters

authors： Lazear EJ,Louie SC

更新日期：1978-01-01 00:00:00

abstract：:The renal handling of cisplatin was investigated in Sprague-Dawley rats in the presence and absence of probenecid and N'-methylnicotinamide. The renal clearance of free cisplatin was not significantly different from the glomerular filtration rate. N'-Methylnicotinamide, an organic cation, did not affect cisplatin clea...

journal_title：Cancer letters

authors： Osman NM,Litterst CL

更新日期：1983-05-01 00:00:00

abstract：:14-3-3 sigma is a negative regulator of the cell cycle and contributes to G2 arrest. Thus far, the lack of its expression due to hypermethylation of the CpG islands has been reported in some carcinomas. In this study, we investigated the expression of 14-3-3 sigma in thyroid neoplasms by means of immunohistochemistry ...

journal_title：Cancer letters

authors： Ito Y,Miyoshi E,Uda E,Yoshida H,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Matsuura N,Kakudo K,Kuma K,Miyauchi A

更新日期：2003-10-28 00:00:00