Abstract：
:Nitric oxide synthase (NOS), an important bioregulator of a variety of biological processes, is overexpressed in colonic tumors of humans and rodents. In this study, effects of L-N(G)-nitroarginine methyl ester (L-NAME), a NOS inhibitor, on development of aberrant crypt foci (ACF) induced by azoxymethane (AOM) in F344 male rats were investigated. Six-week-old male F344 rats were fed diets containing 0 or 100 ppm L-NAME, and given s.c. injections of AOM at 15 mg/kg body wt, once a week for 2 weeks. At 17 weeks of age, all animals were sacrificed and their colons were evaluated for numbers of ACF. Feeding of 100 ppm L-NAME inhibited the development of ACF in different sizes by 24-39%, those containing four or more crypts being most markedly affected. Assessment of silver-stained nucleolar organizer regions protein (AgNORs)/nucleus further revealed a 44% reduction by administration of L-NAME. These results suggest that the NOS inhibitor, L-NAME, may be an effective chemopreventive agent against colon carcinogenesis due to depression of cell proliferation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Kawamori T,Takahashi M,Watanabe K,Ohta T,Nakatsugi S,Sugimura T,Wakabayashi Kdoi
10.1016/s0304-3835(99)00310-9keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
33-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(99)00310-9journal_volume
148pub_type
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