Abstract:
:The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evident when RA233 was present only during re-oxygenation following 4 days of hypoxia. RA233 treatment during both hypoxia and re-oxygenation resulted in the greatest cytotoxicity, with only about 1% of cells surviving such treatment. By contrast, the hypoxic cell sensitizer misonidazole was cytotoxic only when administered during hypoxia. RA233 appears to be a unique hypoxic cell sensitizer that kills long-term hypoxic tumor cells principally during re-oxygenation.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Stackpole CW,Omar RA,Fornabaio DM,Kim YSdoi
10.1016/0304-3835(88)90249-2subject
Has Abstractpub_date
1988-09-01 00:00:00pages
127-31issue
1-2eissn
0304-3835issn
1872-7980pii
0304-3835(88)90249-2journal_volume
42pub_type
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