Characteristics of proliferative lesions in the nasal cavities of mice following chronic inhalation of 1,2-dibromoethane.

Abstract:

:Groups of 50 male and 50 female B6C3F1 mice inhaled 10 or 40 ppm 1,2-dibromoethane 6 h/day, 5 days/week, for 103 (10 ppm) or 90 (40 ppm) weeks. Focal epithelial hyperplasia was found in 1 (low dose group) and 10 (high dose group) males and 3 (low dose group) and 11 (high dose group) females. Squamous papillomas or adenomas were seen in 3 males and 7 females in the high dose groups. Squamous, adeno-, or mixed carcinomas were present in 7 females in the high dose group. One poorly differentiated sarcoma and 2 hemangiosarcomas were observed in females in the low and high dose groups, respectively.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Stinson SF,Reznik G,Ward JM

doi

10.1016/0304-3835(81)90047-1

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

121-9

issue

1-2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(81)90047-1

journal_volume

12

pub_type

杂志文章
  • Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression.

    abstract::The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2016.06.019

    authors: Wang SH,Yang Y,Wu XC,Zhang MD,Weng MZ,Zhou D,Wang JD,Quan ZW

    更新日期:2016-09-28 00:00:00

  • A combined gene delivery by co-transduction of adenoviral and retroviral vectors for cancer gene therapy.

    abstract::A novel second generation retroviral producer cell strategy (an adenoviral/retroviral combined delivery system) has been developed by this laboratory. In the present studies, this delivery system was used to examine its delivery efficiency in vitro and in vivo by using a marker gene, LacZ, and a therapeutic gene, herp...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(02)00241-0

    authors: Pan Y,Zhai P,Dashti AM,Wu S,Lin X,Wu M

    更新日期:2002-10-28 00:00:00

  • Glutathione-S-transferase, alcohol dehydrogenase and aldehyde reductase activities during diethylnitrosamine-carcinogenesis in rat liver.

    abstract::Several enzymes metabolize the toxic aldehydes produced during lipid peroxidation, such as 4-hydroxynonenal. During carcinogenesis induced by diethylnitrosamine in rat liver, an increase in aldehyde dehydrogenase, in comparison with normal liver, has already been shown. This paper demonstrates that, although to a less...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(93)90144-x

    authors: Canuto RA,Muzio G,Maggiora M,Biocca ME,Dianzani MU

    更新日期:1993-02-01 00:00:00

  • Induction of murine fibrosarcomas by low dose treatment with 3-methylcholanthrene followed by promotion with 12-O-tetradecanoyl-phorbol-13-acetate.

    abstract::Repeated application of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) to the skin of mice previously treated with an initiating dose of the carcinogen 7,12-dimethylbenz[a] anthracene has been shown to lead to an increased incidence of papilloma. The studies presented here describe a modified murine tw...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(84)90011-9

    authors: Devens BH,Lundak RL,Byus CV

    更新日期:1984-01-01 00:00:00

  • An inverse correlation between hepatic ornithine decarboxylase and S-adenosylmethionine in rats.

    abstract::The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(81)90018-5

    authors: Mikol YB,Poirier LA

    更新日期:1981-08-01 00:00:00

  • Establishment and characterization of a rat lung adenocarcinoma cell line with low malignant potential.

    abstract::To investigate characteristic of lung adenocarcinoma growth behavior, we have established a cell line (rat lung cancer in Nara (RLCNR)) from a tumor induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in a rat. This clone shows an epithelial cell morphology and grows as sheets in culture with an approximate doubling t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.06.034

    authors: Tsujiuchi T,Mori T,Amanuma T,Tanaka N,Tsutsumi M

    更新日期:2005-01-10 00:00:00

  • Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx.

    abstract::The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stabilit...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2009.03.019

    authors: Park SG,Min JY,Chung C,Hsieh A,Jung G

    更新日期:2009-09-18 00:00:00

  • Aryl hydrocarbon hydroxylase induction in mitogen-stimulated lymphocytes by benzanthracene or cigarette tars adsorbed to asbestos fibers.

    abstract::Human mitogen-stimulated lymphocytes, cultured in the presence of amosite asbestos (AS), demonstrated a slight increase in aryl hydrocarbon hydroxylase (AHH) activity compared with non-induced (control) cultures (P = 0.005). A much greater increase in enzyme activity occurred following addition of the inducers benzant...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(79)80113-5

    authors: McLemore TL,Jenkins WT,Arnott MS,Wray NP

    更新日期:1979-07-01 00:00:00

  • Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines.

    abstract::FOY-305 is a synthetic serine protease inhibitor and ONO-3403 and FO-349 are its derivatives. The effects of these compounds on the proliferation of 13 human neuroblastoma cell lines were investigated in vitro by MTT colorimetric assay. The half maximum inhibition concentrations of ONO-3403 varied between 22 and 90 mi...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(98)00015-9

    authors: Hiwasa T,Kondo K,Nakagawara A,Ohkoshi M

    更新日期:1998-04-24 00:00:00

  • Milk exosomes - Natural nanoparticles for siRNA delivery.

    abstract::Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads i...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2019.02.011

    authors: Aqil F,Munagala R,Jeyabalan J,Agrawal AK,Kyakulaga AH,Wilcher SA,Gupta RC

    更新日期:2019-05-01 00:00:00

  • Cyclic nucleotide concentrations in 1,2-dimethylhydrazine induced rat colon adenocarcinoma.

    abstract::The intracellular concentrations of adenosine 3',5'-cyclic monophosphate (cAMP) in colonic tumors induced in adult male Holtzman rats by 1,2-dimethylhydrazine (DMH) were found to be 1/2 the concentration found in normal large bowel tissue. Intracellular concentrations of guanosine 3'-5'-cyclic monophosphate (cGMP) in ...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(78)93192-0

    authors: Stevens RH,Loven DP,Osborne JW,Prall JP,Lawson AJ

    更新日期:1978-01-01 00:00:00

  • Effects of COX-2 inhibitor on growth of human gastric cancer cells and its relation to hepatocyte growth factor.

    abstract::It is known that hepatocyte growth factor binding to its receptor regulates gastric cancer progression and metastasis. HGF was found to up-regulate the expression of cyclooxygenase-2 gene and increases prostaglandin (PG) synthesis in gastric mucosa cells. Overexpression of COX-2 and increased PG secretion have also be...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.08.026

    authors: Chen JH,Wu CW,Kao HL,Chang HM,Li AF,Liu TY,Chi CW

    更新日期:2006-08-08 00:00:00

  • Inhibition of capping of immunoglobulin and concanavalin A receptors by cis-dichlorodiammine-platinum-(II) in mouse spleen cells.

    abstract::Effects of cis-dichlorodiammineplatinum-(II) (cis-DDP), an anticancer agent, on capping of membrane receptors were investigated in mouse spleen cells in vitro, using fluorescein labeled ligands. Cap formations of surface immunoglobulin and of concanavalin A receptors were significantly reduced by cis-DDP in relation t...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(80)90079-8

    authors: Tsokos GC,Choie DD

    更新日期:1980-09-01 00:00:00

  • Effects of the pineal hormone melatonin on the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system.

    abstract::Only physiological levels of melatonin exert an antiproliferative effect on MCF-7 breast cancer cells grown in an anchorage-dependent culture system. We investigated melatonin's effect on the anchorage-independent growth of MCF-7 cells as well as the dose-response characteristics of this indoleamine under clonogenic c...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(90)90240-x

    authors: Cos S,Blask DE

    更新日期:1990-04-20 00:00:00

  • Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors.

    abstract::Gene delivery vectors, including adenovirus (Ad) and adeno-associated virus (AAV), are inefficient and non-selective for cancer due to low levels of viral receptors with high levels on other tissues, including liver. We tested Ads and AAVs with the SIGYPLP-targeting peptide inserted into virus capsids for transduction...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2003.07.003

    authors: Nicklin SA,Dishart KL,Buening H,Reynolds PN,Hallek M,Nemerow GR,Von Seggern DJ,Baker AH

    更新日期:2003-11-25 00:00:00

  • Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines.

    abstract::In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3835(03)00308-2

    authors: Wink MR,Lenz G,Braganhol E,Tamajusuku AS,Schwartsmann G,Sarkis JJ,Battastini AM

    更新日期:2003-08-20 00:00:00

  • Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies.

    abstract::Monoclonal antibodies were produced and characterized in order to allow the monitoring of the urinary excretion of six modified nucleosides. The specificity of each antibody was determined and competitive solid-phase enzyme-linked immunoassays were designed, the sensitivity of which lay in the pmol range. Detection an...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90296-8

    authors: Reynaud C,Bruno C,Boullanger P,Grange J,Barbesti S,Niveleau A

    更新日期:1992-01-31 00:00:00

  • Contrast-enhanced high-frequency ultrasound imaging of early stage liver metastasis in a preclinical mouse model.

    abstract::Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2013.06.006

    authors: Horie S,Chen R,Li L,Mori S,Kodama T

    更新日期:2013-10-10 00:00:00

  • Intracellular localization and concentration as well as photodynamic effects of benzoporphyrin derivative monoacid ring A in four types of rodent tumor cells.

    abstract::The relative sensitivities of different tumor cells to photodynamic therapy (PDT) with benzoporphyrin derivative monoacid ring A (BPD-MA) were compared in the four tumor cells. A good correlation was observed between the cell survival at 0.1 microg/ml of BPD-MA and sensitizer uptake/10(6) cells (r = -0.99) or the plat...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2005.11.044

    authors: Osaki T,Takagi S,Hoshino Y,Okumura M,Fujinaga T

    更新日期:2006-11-18 00:00:00

  • Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/β-catenin signaling.

    abstract::Peroxiredoxin 2 (Prdx2) has been shown to act as an antioxidant whose main function is to reduce hydrogen peroxide (H2O2) in cells, and Prdx2 is abnormally elevated in colorectal cancer (CRC). However, the functional significance of this up-regulation and the detailed molecular mechanism behind the regulatory effect o...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2013.10.002

    authors: Lu W,Fu Z,Wang H,Feng J,Wei J,Guo J

    更新日期:2014-02-28 00:00:00

  • Rotenone, an anticarcinogen, inhibits cellular proliferation but not peroxisome proliferation in mouse liver.

    abstract::In previous National Toxicology Program (NTP) studies, rotenone reduced the background incidence of hepatocellular carcinoma in male B6C3F1 mice. In the present studies, rotenone reduced the basal hepatic labeling index of male B6C3F1 mice in a dose-dependent fashion and inhibited hepatocellular proliferation, but not...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(95)03869-x

    authors: Cunningham ML,Soliman MS,Badr MZ,Matthews HB

    更新日期:1995-08-16 00:00:00

  • EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.

    abstract::Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in contr...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2016.05.027

    authors: Duan B,Cui J,Sun S,Zheng J,Zhang Y,Ye B,Chen Y,Deng W,Du J,Zhu Y,Chen Y,Gu L

    更新日期:2016-08-28 00:00:00

  • S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line.

    abstract::Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2010.06.007

    authors: Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

    更新日期:2010-12-01 00:00:00

  • Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation.

    abstract::Several classes of plant polyphenols namely, flavonoids, chalcones and coumarins exhibited varying degrees of inhibition on the cell proliferation of human colon adenocarcinoma cell line 220.1. At the highest concentration tested (100 microM), many of the chalcones showed > 100% growth inhibition and their order of po...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(94)90147-3

    authors: Yit CC,Das NP

    更新日期:1994-07-15 00:00:00

  • Inhibitory effect of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid, on azoxymethane-induced intestinal carcinogenesis in rats.

    abstract::Modifying effects of 5-hydroxy-4-(2-phenyl-(E)-ethenyl)-2(5H)-furanone, a novel synthesized retinoid (KYN-54), on intestinal carcinogenesis were examined in a rat model using azoxymethane (AOM). A total of ninety male F344 rats, 6 weeks old, were divided into 4 groups. Group 1 (20 rats) was fed a diet containing KYN-5...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/0304-3835(92)90220-p

    authors: Mori H,Yoshimi N,Sugie S,Tanaka T,Morishita Y,Jinlong G,Tamai Y,Torihara M,Yamahara J

    更新日期:1992-09-30 00:00:00

  • Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma.

    abstract::Human papillomavirus (HPV) DNA integrations may affect therapeutic responses in cancers through ATM network-related DNA damage response (DDR). We studied whether cisplatin-induced DDR was altered in human HK-2 renal tubular cells immortalized by HPV16 E6/E7 genes. Cytotoxicity assays utilized thiazolyl blue dye and DD...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2014.11.008

    authors: Dogra S,Bandi S,Viswanathan P,Gupta S

    更新日期:2015-01-28 00:00:00

  • Updated risk factors to inform early pancreatic cancer screening and identify high risk patients.

    abstract::Pancreatic adenocarcinoma (PDAC) is associated with poor clinical outcomes and incomplete responses to conventional therapy. Therefore, there is an unmet clinical need to better understand the predisposing factors for pancreatic cancer in hopes of providing early screening to high-risk patients. While select risk fact...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2020.04.022

    authors: Principe DR,Rana A

    更新日期:2020-08-10 00:00:00

  • Pediatric human immunodeficiency virus infection and cancer in the highly active antiretroviral treatment (HAART) era.

    abstract::Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.canlet.2014.02.002

    authors: Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

    更新日期:2014-05-28 00:00:00

  • Chemopreventive properties of the ethanol extract of chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells.

    abstract::Much of the interest on the chemopreventive properties of licorice has been focused on the plant genius Glycyrrhiza glabra. In this study the ethanol extract of Chinese licorice root, Glycyrrhiza uralensis (G. uralensis) was investigated for its estrogenic effect and the ability to inhibit cell proliferation in the MC...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2004.12.038

    authors: Jo EH,Kim SH,Ra JC,Kim SR,Cho SD,Jung JW,Yang SR,Park JS,Hwang JW,Aruoma OI,Kim TY,Lee YS,Kang KS

    更新日期:2005-12-18 00:00:00

  • Identification and analysis of CD133(+) melanoma stem-like cells conferring resistance to taxol: An insight into the mechanisms of their resistance and response.

    abstract::The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

    journal_title:Cancer letters

    pub_type: 杂志文章

    doi:10.1016/j.canlet.2013.09.024

    authors: El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

    更新日期:2014-02-01 00:00:00