Identification of human acinar cell carcinoma by monoclonal antibody and in vitro differentiation.

abstract：:The ability of a cancer cell to metastasis to a distant site is partly dependent on the secretion of matrix degrading enzymes. The lysosomal cysteine proteinases, cathepsins B and L, have been shown to be secreted by a number of cancer cells and have been implicated in metastasis. Cathepsins B and L are regulated by a...

journal_title：Cancer letters

authors： Colella R,Goodwyn E,Gopal P

更新日期：2002-11-28 00:00:00

abstract：:Staurosporine and its derivative 7-hydroxystaurosporine are protein kinase inhibitors that are being considered for treatments of cancers. Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds. In this study, we examin...

journal_title：Cancer letters

authors： Zhou W,Lin Y,Wersto R,Chrest J,Gabrielson E

更新日期：2002-09-08 00:00:00

abstract：:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

journal_title：Cancer letters

authors： Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

更新日期：2014-05-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. We analyzed the expression of LPA receptors, vascular endothelial growth factor (VEGF), and interleukin-8 in 97 patients from normal ovary to ovarian cancer, using reverse transcription polymerase chain re...

journal_title：Cancer letters

authors： Fujita T,Miyamoto S,Onoyama I,Sonoda K,Mekada E,Nakano H

更新日期：2003-03-31 00:00:00

abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

journal_title：Cancer letters

authors： Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

更新日期：2008-01-18 00:00:00

abstract：:The ability of tumor cells to adapt to changes in oxygen tension is essential for tumor development. Low oxygen concentration influences cellular metabolism and, thus, affects proliferation, migration, and invasion. A focal point of the cell's adaptation to hypoxia is the transcription factor HIF1α (hypoxia-inducible ...

journal_title：Cancer letters

authors： Paredes F,Williams HC,San Martin A

更新日期：2021-01-11 00:00:00

abstract：:Membrane glycoprotein synthesis was studied in non-tumorigenic and tumor cells treated with the lymphokine hormone, lymphotoxin, to define the biochemical mechanisms by which lymphotoxin prevents carcinogenesis and inhibits growth of tumor cells. Syrian hamster lymphotoxin increased the synthesis of high molecular wei...

journal_title：Cancer letters

authors： Fuhrer JP,Evans CH

更新日期：1983-07-01 00:00:00

abstract：:Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentr...

journal_title：Cancer letters

authors： Price PJ,Gregory EA,Skeen PC

更新日期：1978-12-01 00:00:00

abstract：:Inflammasomes are large multimolecular complexes present in the cytosol of stimulated immune cells; they mediate the activation of caspase-1, leading to cellular pyroptosis. So far, a variety of studies on inflammasomes have emerged, and the best-studied is the NLRP3 inflammasome that is involved in many inflammatory ...

journal_title：Cancer letters

authors： Jiang D,Chen S,Sun R,Zhang X,Wang D

更新日期：2018-04-10 00:00:00

abstract：:Post-transplant lymphoproliferative disorders (PTLDs) represent the most severe complication of both solid organ and hematopoietic stem cell transplantation. The Epstein-Barr Virus (EBV) is the main driver of PTLD, particularly those occurring early after transplantation. EBV-driven malignancies are associated with se...

journal_title：Cancer letters

authors： Petrara MR,Giunco S,Serraino D,Dolcetti R,De Rossi A

更新日期：2015-12-01 00:00:00

abstract：:Multiple cancers contain subpopulations that exhibit characteristics of cancer stem cells (CSCs), the ability to self-renew and seed heterogeneous tumors. Recent evidence suggests two potentially overlapping models for these phenotypes: one where stem cells arise from multipotent progenitor cells, and another where th...

journal_title：Cancer letters

authors： Chang JT,Mani SA

更新日期：2013-11-28 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:Glucosinolates constitute a well-defined group of secondary plant metabolites in cruciferous plants. They occur especially in brassica vegetables, which represent a major part of the human diet. Glucosinolates undergo hydrolysis, catalysed by an endogenous plant enzyme, known as myrosinase, into a range of biological ...

journal_title：Cancer letters

authors： Verkerk R,van der Gaag MS,Dekker M,Jongen WM

更新日期：1997-03-19 00:00:00

abstract：:In this study we combined flow cytometry with fluorescence in situ hybridization to detect numerical aberrations in chromosomes. Fifty-nine human malignant gliomas were examined by flow cytometry for DNA-content and cell cycle analysis and for numerical aberrations of chromosome 1 by in situ hybridization using a chro...

journal_title：Cancer letters

authors： Ehemann V,Hashemi B,Lange A,Otto HF

更新日期：1999-04-26 00:00:00

abstract：:Chronic myeloproliferative disorders (CMPD) are clonal disorders of the hematopoietic stem cell. The myeloid lineage shows increased proliferation with effective maturation, while peripheral leukocytosis, thrombocytosis or elevated red blood cell mass are found. In Philadelphia negative CMPD recurrent cytogenetic abno...

journal_title：Cancer letters

authors： Panani AD

更新日期：2007-09-18 00:00:00

abstract：:Patients with a basal cell carcinomas (BCC) have an increased risk of further tumors. We studied the individual and combined impact of gender, skin type and allelic genes cytochrome P450 (CYP2D6), vitamin D receptor (VDR), tumor necrosis factor-alpha, TNF-alpha) on the rate of increase in BCC numbers after first prese...

journal_title：Cancer letters

authors： Ramachandran S,Fryer AA,Lovatt TJ,Smith AG,Lear JT,Jones PW,Strange RC

更新日期：2003-01-28 00:00:00

abstract：:Mammaglobin B is a recently-isolated gene speculated to belong to the uteroglobin gene family and is overexpressed in primary breast cancers. We investigated mammaglobin B mRNA expression in various cancers of the digestive system. Given the absence of mammaglobin B expression in normal lymph nodes, we also assessed t...

journal_title：Cancer letters

authors： Aihara T,Fujiwara Y,Miyake Y,Okami J,Okada Y,Iwao K,Sugita Y,Tomita N,Sakon M,Shiozaki H,Monden M

更新日期：2000-03-13 00:00:00

abstract：:Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

journal_title：Cancer letters

authors： Connolly JM,Rose DP

更新日期：1998-10-23 00:00:00

abstract：:Cancer stem-like cells (CSLCs) are potential targets for treatment of glioblastoma multiforme (GBM) due to their role in tumorigenesis and recurrence. In this study, we investigated the inhibitory effect of arsenic trioxide (As(2)O(3)) on CSLCs of GBM in human glioma cell lines (U87MG, U251MG and U373MG) in vivo and i...

journal_title：Cancer letters

authors： Zhen Y,Zhao S,Li Q,Li Y,Kawamoto K

更新日期：2010-06-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce DNA methylation of...

journal_title：Cancer letters

authors： Tang X,Tu G,Yang G,Wang X,Kang L,Yang L,Zeng H,Wan X,Qiao Y,Cui X,Liu M,Hou Y

更新日期：2019-06-28 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autophagy in several cance...

journal_title：Cancer letters

authors： Hu W,Chen SS,Zhang JL,Lou XE,Zhou HJ

更新日期：2014-02-28 00:00:00

abstract：:Activation of the BTLA-HVEM co-inhibitory signaling pathway impairs antitumor immunity. Our previous study demonstrated that the extracellular domain of murine BTLA (the soluble form of BTLA) can facilitate HSP70 vaccine-triggered antitumor immunity by blocking BTLA-HVEM interactions in a murine TC-1 non-metastatic tu...

journal_title：Cancer letters

authors： Han L,Wang W,Lu J,Kong F,Ma G,Zhu Y,Zhao D,Zhu J,Shuai W,Zhou Q,Chen P,Ye L,Tao J,Ahmad S,Li F,Sun J

更新日期：2014-11-28 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is the main risk factor for Barrett's tumorigenesis. In this study, we investigated the role of NRF2 in response to exposure to acidic bile salts (ABS), in conditions that mimic GERD, using Barrett's esophagus cell models. We detected an increase in NRF2 protein levels, following...

journal_title：Cancer letters

authors： Peng D,Lu H,Zhu S,Zhou Z,Hu T,Chen Z,Zaika A,El-Rifai W

更新日期：2019-08-28 00:00:00

abstract：:Time trends and the geographical variation of mortality from gastric cancer in Spain are analysed. The national (1961-1980) and the provincial (1975-1980) crude death rates as well as the age adjusted death rates were calculated using the population census (years 1960 and 1970) and the figures for national and provinc...

journal_title：Cancer letters

authors： Palmeiro R,Senra A,Garcia-Blanco P,Millan J

更新日期：1988-09-01 00:00:00

abstract：:Fluorescence-activated cell sorting (FACS) based on the surface marker CD133 is the most common method for isolating glioma stem cells (GSCs) from heterogeneous glioma cell populations. Optimization of this method will have profound implications for the future of GSC research. Five commonly used digestion reagents, Li...

journal_title：Cancer letters

authors： Lv D,Ma QH,Duan JJ,Wu HB,Zhao XL,Yu SC,Bian XW

更新日期：2016-07-10 00:00:00

abstract：:PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...

journal_title：Cancer letters

authors： Thielmann HW,Kuhn C

更新日期：1980-02-01 00:00:00

abstract：:Breast cancer, especially triple-negative breast cancer (TNBC), has limited treatment options. We repurposed the FDA-approved drug bazedoxifene as a novel inhibitor of interleukin 6/glycoprotein 130 signaling. In this study, we investigated the inhibitory effects of bazedoxifene alone or in combination with paclitaxel...

journal_title：Cancer letters

authors： Fu S,Chen X,Lo HW,Lin J

更新日期：2019-04-28 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), an established enzyme-biomarker for prostate cancer, has attracted considerable attention as a target for imaging and therapeutic applications. We aimed to determine the effects of PSMA-targeted photodynamic therapy (PDT) on cytoskeletal networks in prostate cancer cells. PSM...

journal_title：Cancer letters

authors： Liu T,Wu LY,Berkman CE

更新日期：2010-10-01 00:00:00

abstract：:Although patients with localized and regional kidney tumors have a high survival rate, incidence of mortality significantly increases for patients with metastatic disease. It is imperative to decipher the molecular mechanisms of kidney tumor migration and invasion in order to develop effective therapies for patients w...

journal_title：Cancer letters

authors： Kim WJ,Gersey Z,Daaka Y

更新日期：2012-07-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognost...

journal_title：Cancer letters

authors： Cheng Z,Lei Z,Shen F

更新日期：2019-09-28 00:00:00