Abstract:
:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of transcription 3, mammalian target of rapamycin, caspases, intercellular adhesion molecule 1, vascular endothelial growth factor, and poly (ADP-ribose) polymerase in a variety of tumor cells. Importantly, synthetic derivative of OA, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), and its C-28 methyl ester (CDDO-Me) and C28 imidazole (CDDO-Im) have demonstrated potent antiangiogenic and antitumor activities in rodent cancer models. These agents are presently under evaluation in phase I studies in cancer patients. This review summarizes the diverse molecular targets of OA and its derivatives and also provides clear evidence on their promising potential in preclinical and clinical situations.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee Adoi
10.1016/j.canlet.2014.01.016subject
Has Abstractpub_date
2014-05-01 00:00:00pages
206-16issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00042-1journal_volume
346pub_type
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