Matricellular proteins at the crossroad of inflammation and cancer.

abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...

journal_title：Cancer letters

authors： Hermonat PL

更新日期：1994-06-30 00:00:00

abstract：:Enormous efforts have been made to explore small molecules that interfere with the TGF-β signaling pathway, so as to inhibit EMT and the cancer metastasis, but few agents have been identified. In this study, we demonstrated that Nutlin-3 could abolish the down-regulation of E-cadherin induced by TGF-β1 in p53-deficien...

journal_title：Cancer letters

authors： Wu Y,Fu Y,Zheng L,Lin G,Ma J,Lou J,Zhu H,He Q,Yang B

更新日期：2014-01-01 00:00:00

abstract：:VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In v...

journal_title：Cancer letters

authors： Fuereder T,Jaeger-Lansky A,Hoeflmayer D,Preusser M,Strommer S,Cejka D,Koehrer S,Crevenna R,Wacheck V

更新日期：2010-10-28 00:00:00

abstract：:The present study was undertaken to determine the kinetics of DNA synthesis and expression of cell cycle dependent proto-oncogenes in response to two types of cell proliferative stimuli in male Wistar rat liver. The peak of DNA synthesis was approximately 24 h after a compensatory cell proliferative stimulus induced b...

journal_title：Cancer letters

authors： Coni P,Bignone FA,Pichiri G,Ledda-Columbano GM,Columbano A,Rao PM,Rajalakshmi S,Sarma DS

更新日期：1989-09-15 00:00:00

abstract：:Hepatocellular Carcinoma (HCC) in high-incidence areas (sub-Saharan Africa, South-Eastern Asia) often contains a somatic mutation at codon 249 in TP53 (R249S). This mutation is rare in low-incidence areas of Europe and the United States. There is evidence that R249S occurs as the result of mutagenesis by aflatoxin in ...

journal_title：Cancer letters

authors： Gouas D,Shi H,Hainaut P

更新日期：2009-12-01 00:00:00

abstract：:uPA system plays an important role in cancer invasion and metastasis. The binding of uPA to its receptor, uPAR, is necessary for the activation of uPA system. We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopatholo...

journal_title：Cancer letters

authors： Giannopoulou I,Mylona E,Kapranou A,Mavrommatis J,Markaki S,Zoumbouli Ch,Keramopoulos A,Nakopoulou L

更新日期：2007-02-08 00:00:00

abstract：:In order to determine the effects of intermittent hormonal manipulation on the promotion stage of rat prostate carcinogenesis, testosterone and/or estrogen were administered to F344 rats for 40 weeks after 20-weeks treatment with the prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl. For this purpose testosterone pro...

journal_title：Cancer letters

authors： Cui L,Mori T,Takahashi S,Imaida K,Akagi K,Yada H,Yaono M,Shirai T

更新日期：1998-01-09 00:00:00

abstract：:cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes...

journal_title：Cancer letters

authors： Liu AY,Bradner RC,Vessella RL

更新日期：1993-10-15 00:00:00

abstract：:The (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive an...

journal_title：Cancer letters

authors： Phillips DH

更新日期：2013-06-28 00:00:00

abstract：:The B16 malignant melanoma and its F1 variant line were described and compared in syngeneic C57BL/6 mice at short and long term periods after transplantation. No observable differences in gross or histological features were noted. In both lines, liver and lung metastasis was confirmed and kidney colonization proposed....

journal_title：Cancer letters

authors： Wosko TJ,Ferrara DT,Sartori LS

更新日期：1984-08-01 00:00:00

abstract：:Medulloblastoma (MB) is the most frequent malignant brain tumour in children with a poor outcome. Divided into four molecular subgroups, MB of the Sonic hedgehog (SHH) subgroup accounts for approximately 25% of the cases and is driven by mutations within components of the SHH pathway, such as its receptors PTCH1 or SM...

journal_title：Cancer letters

authors： Niesen J,Ohli J,Sedlacik J,Dührsen L,Hellwig M,Spohn M,Holsten T,Schüller U

更新日期：2020-05-01 00:00:00

abstract：:EGCG [(-)epigallocatechin-3-gallate], a green tea-derived polyphenol, has been shown to suppress cancer cell proliferation, and interfere with the several signaling pathways and induce apoptosis. Practically, there is emerging evidence that EGCG has a potential to increase the efficacy of chemotherapy in patients. We ...

journal_title：Cancer letters

authors： Hwang JT,Ha J,Park IJ,Lee SK,Baik HW,Kim YM,Park OJ

更新日期：2007-03-08 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:Cytotoxic effects of 3-deazaguanosine (3-DGUO) result from the inhibition of DNA synthesis and incorporation of the drug into DNA. Synergistic antiproliferative effects of a combination of 3-deazaguanosine and 2-beta-D-ribofuranosylthiazole-4-carboxamide, a potent inhibitor of inosine monophosphate dehydrogenase, was ...

journal_title：Cancer letters

authors： Jacobsen SJ,Page T,Diala ES,Nyhan WL,Robins RK,Mangum JH

更新日期：1987-04-01 00:00:00

abstract：:The porphyrin content of cells labelled with hematoporhyrin derivative (Hpd) and tumours of mice injected with Hpd was analysed by means of high pressure liquid chromatography (HPLC). The components of Hpd may be classified in 3 groups: (A) Components with a high fluorescence quantum yield and with sharp peaks in the ...

journal_title：Cancer letters

authors： Moan J,Sommer S

更新日期：1983-12-01 00:00:00

abstract：:Recent studies show that metabolic patterns typical of cancer cells, including aerobic glycolysis and increased lipogenesis, are not unique to malignancy, but rather originate in physiologic development. In the postnatal brain, where sufficient oxygen for energy metabolism is scrupulously maintained, neural progenitor...

journal_title：Cancer letters

authors： Tech K,Deshmukh M,Gershon TR

更新日期：2015-01-28 00:00:00

abstract：:Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...

journal_title：Cancer letters

authors： Beloussow K,Wang L,Wu J,Ann D,Shen WC

更新日期：2002-09-26 00:00:00

abstract：:Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The effect of farnesol (FOH) on STAT3 activation, associated pro...

journal_title：Cancer letters

authors： Lee JH,Kim C,Kim SH,Sethi G,Ahn KS

更新日期：2015-05-01 00:00:00

abstract：:Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a liga...

journal_title：Cancer letters

authors： Lee JH,Yoon JH,Yu SJ,Chung GE,Jung EU,Kim HY,Kim BH,Choi DH,Myung SJ,Kim YJ,Kim CY,Lee HS

更新日期：2010-09-28 00:00:00

abstract：:Serial determinations of urinary biopterin were performed in rats during the development of lung tumors induced by radon inhalation and 5,6-benzonaphtoflavone administration. A striking increase in biopterin levels was observed in animals which developed single or multiple epidermoid carcinoma of the lung and this inc...

journal_title：Cancer letters

authors： Mura P,Morlier JP,Barriere M,Bredon P,Papet Y,Chameaud J

更新日期：1990-10-08 00:00:00

abstract：:We have investigated the effects of interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) on meningioma cells in two different culture systems, evaluated by the uptake of radiolabelled methionine. With both IFN-alpha and 5-FU an inhibitory effect on the uptake of radiolabelled methionine by the meningioma cells was d...

journal_title：Cancer letters

authors： Zhang ZJ,Wang JL,Muhr C,Smits A

更新日期：1996-02-27 00:00:00

abstract：:The human multidrug resistance ABC transporters provide a protective function in our body against a large number of toxic compounds. These proteins, residing in the plasma membrane, perform an active, ATP-dependent extrusion of such xenobiotics. However, the same proteins are also used by the tumor cells to fight vari...

journal_title：Cancer letters

authors： Cervenak J,Andrikovics H,Ozvegy-Laczka C,Tordai A,Német K,Váradi A,Sarkadi B

更新日期：2006-03-08 00:00:00

abstract：AIM:To estimate the incidence and latency of Vaginal Intraepithelial Neoplasia (VAIN) in women previously hysterectomized for benign/malign pathology and to evaluate the role of high risk HPVs in the prediction of persistent or recurrent disease. SUBJECTS AND METHODS:830 women with prior hysterectomy for benign/malign...

journal_title：Cancer letters

authors： Frega A,French D,Piazze J,Cerekja A,Vetrano G,Moscarini M

更新日期：2007-05-08 00:00:00

abstract：:Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....

journal_title：Cancer letters

authors： Fan Z,Duan J,Wang L,Xiao S,Li L,Yan X,Yao W,Wu L,Zhang S,Zhang Y,Li Y,Zhu X,Hu Y,Zhang D,Jiao S,Xu X

更新日期：2019-05-28 00:00:00

abstract：:The effect of diethylstilbestrol propionate (DES; 1 mg/kg body wt. was studied in the female offspring of rats exposed subcutaneously on the 19th day of gestation. Examination of vaginal smears showed persistent estrus in adult rats treated prenatally with DES. Compensatory ovarian hypertrophy (COH) induced by hemicas...

journal_title：Cancer letters

authors： Napalkov NP,Anisimov VN

更新日期：1979-02-01 00:00:00

abstract：:In order to characterize the enzymes involved in the purine nucleotide catabolism as indicators of invasiveness and aggressiveness of malignant gliomas, the degradation of extracellular nucleotides by five different glioma cell lines was investigated and compared with primary astrocytes. Rapid hydrolysis of extracellu...

journal_title：Cancer letters

authors： Wink MR,Lenz G,Braganhol E,Tamajusuku AS,Schwartsmann G,Sarkis JJ,Battastini AM

更新日期：2003-08-20 00:00:00

abstract：:Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...

journal_title：Cancer letters

authors： Mandai M,Matsumura N,Baba T,Yamaguchi K,Hamanishi J,Konishi I

更新日期：2011-11-28 00:00:00

abstract：:Chloroform is a liver carcinogen in mice and a kidney carcinogen in rats. It is thought to act through a non-genotoxic-cytotoxic mode of action. Changes in expression of growth control genes accompanying chloroform-induced cytolethality and regeneration may play a part in the development of chloroform-induced tumors. ...

journal_title：Cancer letters

authors： Sprankle CS,Larson JL,Goldsworthy SM,Butterworth BE

更新日期：1996-03-19 00:00:00

abstract：:Costunolide, the predominant sesquiterpene lactone in Saussureae radix, has been reported to exhibit potent chemopreventive effects on carcinogenesis. Effects of costunolide on cellular activation induced by a tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) were investigated using a reporter g...

journal_title：Cancer letters

authors： Fukuda K,Akao S,Ohno Y,Yamashita K,Fujiwara H

更新日期：2001-03-10 00:00:00

abstract：:This study focused on the role of focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase important for many cellular processes, in the proliferation, adhesion, and invasion of melanoma cells in vitro and in vivo. We found that the Y925F-mutation of FAK in B16F10 melanoma cells suppressed metastasis in an experimen...

journal_title：Cancer letters

authors： Kaneda T,Sonoda Y,Ando K,Suzuki T,Sasaki Y,Oshio T,Tago M,Kasahara T

更新日期：2008-11-08 00:00:00