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Coming of a precision era of the staging systems for intrahepatic cholangiocarcinoma?

Abstract：

:Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer. Appropriate treatment of this aggressive and heterogeneous cancer requires accurate staging and prognostic stratification, as does patient selection for clinical trials. Over the past two decades, several staging systems and prognostic models for ICC have been developed. Most include independent prognostic factors such as tumor extent, clinical parameters and histopathological features and are inaccurate. Accumulating findings offer new insights into the genetic and molecular basis of ICC progression. Hence, staging systems and prognostic models that incorporate in clinicalpathological factors, molecular and genomic information, and tumor biomarkers, and hence more accurately estimate prognosis, will become a reality. This review summarizes the current staging systems and prognostic models for ICC and highlights the need to establish more precise and personalized systems and models that incorporate tumor biologic factors.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Cheng Z,Lei Z,Shen F

doi

10.1016/j.canlet.2019.114426

subject

Has Abstract

pub_date

2019-09-28 00:00:00

pages

10-17

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(19)30348-9

journal_volume

460

pub_type

杂志文章,评审

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