Abstract:
:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Morgan WF,Sowa MBdoi
10.1016/j.canlet.2013.09.009subject
Has Abstractpub_date
2015-01-01 00:00:00pages
17-21issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00662-9journal_volume
356pub_type
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