Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death.

abstract：:The incidence of carcinomas highly increases with age. However, the initial steps of the age-related molecular carcinogenic processes remain poorly characterized. We previously showed that normal human epidermal keratinocytes spontaneously and systematically escape from senescence to give rise to preneoplastic emergin...

journal_title：Cancer letters

authors： Drullion C,Marot G,Martin N,Desle J,Saas L,Salazar-Cardozo C,Bouali F,Pourtier A,Abbadie C,Pluquet O

更新日期：2018-12-01 00:00:00

abstract：:The effect of glucocorticoids on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inhibition of gap-junctional intercellular communication (GJIC) and morphological transformation in Syrian hamster embryo (SHE) cells was examined. Fluocinolone acetonide (FA) and dexamethasone (DEX) almost completely suppressed the ef...

journal_title：Cancer letters

authors： Roseng LE,Rivedal E

更新日期：1993-08-16 00:00:00

abstract：:The tumor promoter, phorbol-12-myristate-13-acetate (PMA), elicited a significant increase in lysosomal membrane permeability, as measured by release of free beta-glucurnidase, in guinea pig and hamster isolated hepatic lysosomes in vitro. This response was antagonized by zinc sulfate; zinc compounds having previously...

journal_title：Cancer letters

authors： Pfeiffer CJ,Cho CH

更新日期：1980-07-01 00:00:00

abstract：:Naturally occurring fecal mutagens, called fecapentaenes, are hypothesized to contribute to large bowel carcinogenesis. To understand health risks it is necessary to relate fecal mutagen concentrations to intestinal pathologies, i.e. colon cancer. However, fast and reliable methods for analysis of stool for fecapentae...

journal_title：Cancer letters

authors： Kleinjans JC,Pluijmen MH,Hageman GJ,Verhagen H

更新日期：1989-01-01 00:00:00

abstract：:Post-initiation modifying effects of dietary administration of a super critical extract of propolis on major organs were examined using a two-stage carcinogenesis model. Groups of 21 or 22 F344 female rats were treated sequentially with 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN, i.g.), 7,12-dimethylbenz[a]anthracene...

journal_title：Cancer letters

authors： Kimoto N,Hirose M,Kawabe M,Satoh T,Miyataka H,Shirai T

更新日期：1999-12-01 00:00:00

abstract：:We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expre...

journal_title：Cancer letters

authors： Iwahashi S,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Takasu C,Saito Y,Yamada S

更新日期：2016-05-28 00:00:00

abstract：:Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiati...

journal_title：Cancer letters

authors： Ramírez MJ,Minguillón J,Loveless S,Lake K,Carrasco E,Stjepanovic N,Balmaña J,Català A,Mehta PA,Surrallés J

更新日期：2020-03-01 00:00:00

abstract：:We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cel...

journal_title：Cancer letters

authors： Zhu Y,James RM,Peter A,Lomas C,Cheung F,Harrison DJ,Bader SA

更新日期：2004-04-30 00:00:00

abstract：:The NM23 family proteins are involved in a variety of biological processes including tumor metastasis, development, and differentiation; however, their functions in the regulation of cellular proliferation are poorly understood. We have investigated the role of one NM23 family protein, NM23H2, in the regulation of cel...

journal_title：Cancer letters

authors： Lee MY,Jeong WJ,Oh JW,Choi KY

更新日期：2009-03-18 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...

journal_title：Cancer letters

authors： Lu Z,Li Y,Che Y,Huang J,Sun S,Mao S,Lei Y,Li N,Sun N,He J

更新日期：2018-09-28 00:00:00

abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

journal_title：Cancer letters

authors： Deangelo AB,Garrett CT

更新日期：1983-09-01 00:00:00

abstract：:The bmi-1 gene was identified as a common proviral integration site in Moloney murine leukemia virus. In the present studies, we cloned and sequenced the rat bmi-1 gene by reverse transcriptase-polymerase chain reaction (RT-PCR) using degenerate PCR primers of homologous sequences between mouse and human. We found 93%...

journal_title：Cancer letters

authors： Osaka M,Koami K,Sugiyama T

更新日期：1998-11-13 00:00:00

abstract：:Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...

journal_title：Cancer letters

authors： Mulder SE,Dasgupta A,King RJ,Abrego J,Attri KS,Murthy D,Shukla SK,Singh PK

更新日期：2020-10-28 00:00:00

abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

journal_title：Cancer letters

authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

更新日期：2014-05-28 00:00:00

abstract：:Cancer stem cells (CSCs), which comprise a small proportion of total cancer cells, have special capacities for self-renewal, differentiation and tumor formation. Currently, CSCs are regarded as the major cause of the failure in anticancer therapy, such as chemoresistance and/or radioresistance, tumor recurrence and me...

journal_title：Cancer letters

authors： Lei Y,Zhang D,Yu J,Dong H,Zhang J,Yang S

更新日期：2017-05-01 00:00:00

abstract：:The widespread consumption of tea as beverage throughout the world has stimulated interest in the possibility of its use in chemoprevention of cancer. The present set of investigation was carried out to evaluate the anticarcinogenic activity of black tea using lung tumorigenesis model in Swiss albino mice. Diethylnitr...

journal_title：Cancer letters

authors： Shukla Y,Taneja P

更新日期：2002-02-25 00:00:00

abstract：:Elevated cyclooxygenase-2 (COX-2) expression has been observed in various types of cancer. Induction of COX-2 expression has been reported to increase invasiveness and angiogenesis of tumours. While COX-2 overexpression has been repeatedly proven to promote tumor growth, little is known about what initiates its induct...

journal_title：Cancer letters

authors： Cressey R,Pimpa S,Tontrong W,Watananupong O,Leartprasertsuke N

更新日期：2006-02-28 00:00:00

abstract：:Aristolochic acid (AA), a component of some Chinese herbal medicines, may cause Chinese Herbs Nephropathy (CHN) and multi-systemic tumors by the formation of AA-DNA adducts. In this study, we established an animal model to further characterize the mechanisms of AA-induced diseases. Our results indicated that AA signif...

journal_title：Cancer letters

authors： Cheng CL,Chen KJ,Shih PH,Lu LY,Hung CF,Lin WC,Yesong Gu J

更新日期：2006-02-08 00:00:00

abstract：:In vitro cultured r/mHM-SFME-1 cells were injected into the hind foot pads of Balb/c mice. Metastasis was detected in the lungs of tumor-bearing mice by means of both PCR and histological methods. Primers for the PCR were set to amplify a 128 bp exon-1 sequence of the human c-Ha-ras1 gene which had been introduced int...

journal_title：Cancer letters

authors： Matano S,Ryoyama K,Nakamura S,Okada G,Nomura T

更新日期：1995-05-04 00:00:00

abstract：:Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in...

journal_title：Cancer letters

authors： Jacobs MM,Jansson B,Griffin AC

更新日期：1977-01-01 00:00:00

abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

journal_title：Cancer letters

authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

更新日期：2013-05-01 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:Epigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis. Through methylome study, we identified BCLB as a methylated gene in HCC. BCLB was methylated in all tumor cell lines with silenced or reduced expression. BCLB was furth...

journal_title：Cancer letters

authors： Liu X,Hu X,Kuang Y,Yan P,Li L,Li C,Tao Q,Cai X

更新日期：2017-06-01 00:00:00

abstract：:Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand...

journal_title：Cancer letters

authors： London WB,Boni L,Simon T,Berthold F,Twist C,Schmidt ML,Castleberry RP,Matthay KK,Cohn SL,De Bernardi B

更新日期：2005-10-18 00:00:00

abstract：:The vectors PAI2, C595 and Herceptin target the membrane-bound uPA, MUC1 and HER2 antigens expressed by cancer cells, respectively. The expression of these receptors was tested in the ovarian cancer cell line OVCAR-3; MUC-1 was strongly expressed (3+), uPA moderately expressed (2+), but HER2 was negative (-). The alph...

journal_title：Cancer letters

authors： Song YJ,Qu CF,Rizvi SM,Li Y,Robertson G,Raja C,Morgenstern A,Apostolidis C,Perkins AC,Allen BJ

更新日期：2006-03-28 00:00:00

abstract：:The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution wi...

journal_title：Cancer letters

authors： Dornish JM,Pettersen EO

更新日期：1989-07-01 00:00:00

abstract：:Nitrosatability of dried Nigerian vegetables and spices was investigated under simulated gastric conditions. N-Nitroso-dimethylamine (NDMA) was the only volatile nitrosamine found above the preformed level except in ugwu where N-nitroso-piperidine (2.3 ppb) was also detected. The lowest NDMA value of 0.4 ppb was found...

journal_title：Cancer letters

authors： Atawodi SE,Maduagwu EN,Preussmann R,Spiegelhalder B

更新日期：1991-05-24 00:00:00

abstract：:The process of cooking beef substances which are mutagenic in the Ames Salmonella/microsome bioassay [1,2]. In this study, the formation and disposition of basic mutagens produced by cooking beef at different temperatures were examined. Mutagenic activity increased exponentially with cooking temperature between 137 de...

journal_title：Cancer letters

authors： Rappaport SM,McCartney MC,Wei ET

更新日期：1979-12-01 00:00:00

abstract：:An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore, an active principle of the extract, the furanoheliangolide sesquiterpene lactone lobatin B, was isolated and te...

journal_title：Cancer letters

authors： Kiss I,Unger C,Huu CN,Atanasov AG,Kramer N,Chatruphonprasert W,Brenner S,McKinnon R,Peschel A,Vasas A,Lajter I,Kain R,Saiko P,Szekeres T,Kenner L,Hassler MR,Diaz R,Frisch R,Dirsch VM,Jäger W,de Martin R,Bochkov

更新日期：2015-01-28 00:00:00

abstract：:Oncogenic transformation of mouse C3H10T1/2 cells induced by X-rays was suppressed in the presence of extract of Rooibos tea, Aspalathus linealis. Transformation was reduced with increased concentration of the extract, so that at an extract concentration of 10%, transformation incidence was similar to the spontaneous ...

journal_title：Cancer letters

authors： Komatsu K,Kator K,Mitsuda Y,Mine M,Okumura Y

更新日期：1994-02-28 00:00:00