Abstract:
:We reported that poor prognoses of hepatocellular carcinoma (HCC) patients after radiofrequency ablation (RFA) are owing to up-regulation of expression of hypoxia-inducible factor-1 and epithelial cell adhesion molecule. We investigated aggressive progression in residual liver tumors (RLTs) after RFA to focus on expression of epithelial-mesenchymal transition (EMT)-related genes and miRNAs. Ten patients with recurrent HCC post-RFA who underwent hepatectomy (RFA group) and 78 patients with HCC without prior RFA (non-RFA group) were enrolled. We examined expression of transforming growth factor (TGF)-β, Twist, vimentin, and Snail-1 mRNAs in tumor tissues, and expression of miR-34a and miR-200c. Expression of TGF-β, Twist and Snail-1 in the RFA group was significantly higher than that in the non-RFA group (P < 0.05); vimentin expression in the RFA group was higher than that in the non-RFA group (P = 0.07). Expression of miR-200c and miR-34a in the RFA group was significantly lower than that in the non-RFA group (miR-200c: P = 0.04; miR-34a: P < 0.01). Increased expression of EMT markers through down-regulation of miRNA expression in RLTs after RFA may be related to poor prognoses of HCC patients with aggressive local recurrence after RFA.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Iwahashi S,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Takasu C,Saito Y,Yamada Sdoi
10.1016/j.canlet.2016.02.041subject
Has Abstractpub_date
2016-05-28 00:00:00pages
47-50issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(16)30109-4journal_volume
375pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90004-x
更新日期:1980-01-01 00:00:00
abstract::The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(81)90018-5
更新日期:1981-08-01 00:00:00
abstract::Although novel agents effective against malignant mesothelioma (MM) have been developed, the prognosis of patients with MM is still poor. We generated a DNA-chimeric siRNA against polo-like kinase-1 (PLK-1), which was more stable in human serum than the non-chimeric siRNA. The chimeric PLK-1 siRNA inhibited MM cell pr...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2010.02.008
更新日期:2010-08-28 00:00:00
abstract::Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.01.006
更新日期:2012-06-28 00:00:00
abstract::We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E receptor subtype EP(1) using a genetic approach in EP(1)-knockout mice and a pharmacological approach with the EP(1) selective antagonist, ONO-8711. In the present study, we examined the effect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00440-7
更新日期:2000-08-01 00:00:00
abstract::Preventive intervention of colorectal cancer has become essential as a major portion of the population may develop the disease at some points during their lives. Diet and nutrition play an important role during this multistep colon carcinogenic process. Inhibitory activity of aqueous suspensions of garlic and tomato, ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2003.11.024
更新日期:2004-05-28 00:00:00
abstract::Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90104-4
更新日期:1992-03-15 00:00:00
abstract::Increasing evidence suggests that DLL4 (Delta-like 4)-Notch signaling plays a critical role in cell fate determination and differentiation in tissues. Blocking DLL4-Notch signaling results in inhibition of tumor growth, which is associated with increased nonfunctional vessels and poor perfusion in the tumor. We succes...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2015.12.025
更新日期:2016-03-01 00:00:00
abstract::Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2014.05.014
更新日期:2014-08-28 00:00:00
abstract::We have reported that the ectopic expression of progesterone receptor (PR) in MCF-7 cells disrupted the effects of estradiol-17beta (E2), and this anti-estrogenic effect of PR was associated with heightened E2 metabolism and inhibition of estrogen receptor (ER) binding to estrogen response element (ERE). This study de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.03.040
更新日期:2008-09-18 00:00:00
abstract::Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natur...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.08.003
更新日期:2018-10-28 00:00:00
abstract::Effects of eight heterocyclic amines (HCAs) on pancreatic duct carcinogenesis were investigated in a rapid production model in hamsters. N-Nitrosobis(2-oxopropyl)amine (BOP) was given to effect initiation, followed by augmentation pressure consisting of four daily i.p. injections of 500 mg/kg DL-ethionine, a choline-d...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00131-7
更新日期:1999-09-01 00:00:00
abstract::Starvation-induced hypoglycaemia and streptozotocin-induced diabetes suppressed the growth of Ehrlich ascites tumor in mice. The suppression of tumor growth by diabetes was alleviated by administration of insulin. The number of glucose carriers on tumour cells was found to be reduced in diabetes and partial resumption...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(85)90035-7
更新日期:1985-09-30 00:00:00
abstract::Diabetes mellitus type II (DM) and immune cell infiltration determine patient outcome in many tumor entities. Here we studied a possible link between the metabolic and immune cell status of OSCC patients. Glucose transporter (GLUT) 1 mRNA expression was elevated in all tumor samples, whereas other glycolytic markers s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.11.029
更新日期:2021-02-28 00:00:00
abstract::Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.07.027
更新日期:2013-10-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are an homologous family of proteolytic enzymes capable of degrading components of the extracellular matrix (ECM) and thereby facilitating the invasion of tumour cells into normal tissues. The neural cell adhesion molecules (NCAMs) of neuronal and glial cells provide a Ca2+-independent...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00171-7
更新日期:1997-06-03 00:00:00
abstract::Tumor promotion potential of diacylglycerol (DAG)-rich edible oil was examined using a two-stage mouse skin carcinogenesis model initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Topical treatment with 75 mg DAG oil once a day for 5 days/week for 35 weeks caused papillomas in 4 of 23 (17%) DMBA-treated female ICR ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2008.10.016
更新日期:2009-03-08 00:00:00
abstract::A series of experiments was carried out to assess cytotoxic and cytogenetic effects in bone marrow polychromatic erythrocytes (PCE) and pulmonary alveolar macrophages (PAM) resulting from individual or combined exposure of male BD6 rats to ethanol, cigarette smoke and Aroclor 1254. Addition of 5% ethanol to drinking w...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90127-u
更新日期:1993-08-31 00:00:00
abstract::A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic str...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90043-0
更新日期:1984-02-01 00:00:00
abstract::Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.03.025
更新日期:2013-08-19 00:00:00
abstract::The human myelocytic leukemia cell line HL-60 is a useful model for the study of cellular differentiation. Phorbol 12-myristate 13-acetate (PMA) induces the monocyte/macrophage-like differentiation of HL-60 cells and results in growth arrest, increasing adherence. In PMA-induced differentiation of HL-60 cells, phospho...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00505-5
更新日期:2001-09-28 00:00:00
abstract::Oral treatment with reduced glutathione for 10 weeks has no effect on the development of tumours from aflatoxin B1-induced gamma-glutamyl transpeptidase-positive pre-neoplastic focal lesions. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90086-1
更新日期:1983-11-01 00:00:00
abstract::Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2017.07.031
更新日期:2017-10-28 00:00:00
abstract::One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of well-tolerated doses of HDACis to platinum-based chemotherapeutics has been proven in vitro and in ...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2012.09.018
更新日期:2013-02-01 00:00:00
abstract::The in vitro chemosensitizing effect of triptolide (PG490) on the cytotoxicity of 5-fluorouracil (5-FU) was determined in three colorectal cancer (CRC) cell lines. PG490 alone was toxic to CRC cell lines (IC(50)s: 1.39-5.51nM). The cytotoxicity of 5-FU to CRC cell lines was 4-15-fold sensitized by combining use of low...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2009.10.013
更新日期:2010-05-28 00:00:00
abstract::Several natural phenolic compounds were tested in vitro for their effect on the activity of protein kinase C isolated from liver cytosol, particulate and nuclear fractions of normal and aflatoxin B1 treated rats. Quercetin and kaempferol inhibited the enzyme activity of all these fractions at very low dose levels. The...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00337-6
更新日期:1997-12-16 00:00:00
abstract::The cell inactivating effect of cis-dichlorodiammineplatinum(II) in combination with 2-substituted benzaldehyde derivatives was tested using cultured human NHIK 3025 cells. Simultaneous drug combination with benzaldehyde protected cells from cis-DDP-induced cell inactivation in a dose-dependent manner. Substitution wi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90216-4
更新日期:1989-07-01 00:00:00
abstract::Mice with hereditary intestinal polyposis have mutations of the APC gene which causes formation of multiple polyps. At least one other gene influences the susceptibility for development of polyps in mice, and the locus was named Mom1. The causative gene for the Mom1 locus has recently been cloned and was found to be i...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(96)04503-x
更新日期:1997-01-01 00:00:00
abstract::Chromosomal assignment of human transcribed sequences has been done mainly by high throughput genome analysis in specialized genome centres and, in a more classical fashion, by fluorescence in-situ hybridization (FISH) analysis. Not every laboratory has the ability to map cDNAs by FISH analysis. We here report a rapid...
journal_title:Cancer letters
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1016/s0304-3835(00)00690-x
更新日期:2001-01-10 00:00:00
abstract::Helicobacter pylori (H. pylori) infection is considered a major risk factor for gastric cancer. CagA behaves as a major bacterial oncoprotein playing a key role in H. pylori-induced tumorigenesis. Cancer stem cells (CSCs) are believed to possess the ability to initiate tumorigenesis and promote progression. Although s...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.032
更新日期:2016-05-01 00:00:00