An inverse correlation between expression of NCAM-A and the matrix-metalloproteinases gelatinase-A and gelatinase-B in human glioma cells in vitro.

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...

journal_title：Cancer letters

authors： Chen S,Cao Q,Wen W,Wang H

更新日期：2019-09-28 00:00:00

abstract：:The lack of effective anti-tumor therapy for renal cell carcinoma (RCC) has stimulated the search for novel target whose inhibition could block tumorigenesis. Recently, reduced DLC-1 has been shown to be associated with aggressive and highly metastatic renal cell carcinoma. In this study, the biological role of DLC-1 ...

journal_title：Cancer letters

authors： Zhang T,Zheng J,Jiang N,Wang G,Shi Q,Liu C,Lu Y

更新日期：2009-09-28 00:00:00

abstract：:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blott...

journal_title：Cancer letters

authors： Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya E

更新日期：2002-12-10 00:00:00

abstract：:Patients with inadequate anti-cancer T cell responses experience limited benefit from immune checkpoint inhibitors and other immunotherapies that require T cells. Therefore, treatments that induce de novo anti-cancer T cell immunity are needed. One strategy - referred to as in situ vaccination - is to deliver chemothe...

journal_title：Cancer letters

authors： Lynn GM,Laga R,Jewell CM

更新日期：2019-09-10 00:00:00

abstract：:Stress conditions induced by routine treatments might affect cancer-associated fibroblasts in lung adenocarcinoma. The present study tried to explore transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and anti-angiogenesis ther...

journal_title：Cancer letters

authors： Li Y,Chen Y,Miao L,Wang Y,Yu M,Yan X,Zhao Q,Cai H,Xiao Y,Huang G

更新日期：2021-01-28 00:00:00

abstract：:In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These proteins act as molecular chaperones by assisting proper folding and refolding of misfolded proteins and aid in the elimination of old and damaged cells. HSPs include Hsp100, Hsp90, Hsp70, Hsp40, and small HSPs. Through its substrate...

journal_title：Cancer letters

authors： Kumar S,Stokes J 3rd,Singh UP,Scissum Gunn K,Acharya A,Manne U,Mishra M

更新日期：2016-04-28 00:00:00

abstract：:Transcripts from the murine gene family proliferin, which are increased by a wide assortment of chemical promoters of C3H10T1/2 cell morphological transformation, were shown to be induced by tri-n-butyltin chloride at concentrations above 50 nM. Two-stage transformation assays, with 3-methylcholanthrene as inducer and...

journal_title：Cancer letters

authors： Parfett CL,Pilon R

更新日期：1993-07-30 00:00:00

abstract：:Gene amplification has been found to be biologically important in cancer. We report a complementary DNA sequence obtained using a subtractive hybridization approach which is frequently and highly amplified in human gliomas. 39/45 (87%) glial tumor specimens (of pathologically low and high grade) revealed increases in ...

journal_title：Cancer letters

authors： Liang BC,Hays L

更新日期：1996-08-02 00:00:00

abstract：:Of the erythropoietin-producing human hepatocellular receptors (Ephs), EphB4 has recently emerged as a potential target in several cancers due to its roles in modified cell migration and invasion. As little is known about the roles of EphB4 in glioma, we sought to investigate its function in glioma by in vitro cell mi...

journal_title：Cancer letters

authors： Kawahara Y,Furuta T,Sabit H,Tamai S,Dong Y,Jiapaer S,Zhang J,Zhang G,Oishi M,Miyashita K,Hayashi Y,Nakada M

更新日期：2019-05-01 00:00:00

abstract：:The thiol N-acetylcysteine (NAC), a precursor of intracellular glutathione (GSH), efficiently prevented the induction of lung tumors in Swiss albino mice, when supplemented to the diet (0.2%) both before and after an i.p. injection of the carcinogen urethan (ethyl carbamate). Irrespective of urethan administration, NA...

journal_title：Cancer letters

authors： De Flora S,Astengo M,Serra D,Bennicelli C

更新日期：1986-09-01 00:00:00

abstract：:The regulation of MYC-regulated long non-coding RNAs has been reported to contribute to certain types of cancers. However, the role of MYC-induced long non-coding RNA (MINCR) in the tumorigenesis of gallbladder cancer (GBC) is still largely unknown. In this study, we discovered that MINCR was markedly upregulated in G...

journal_title：Cancer letters

authors： Wang SH,Yang Y,Wu XC,Zhang MD,Weng MZ,Zhou D,Wang JD,Quan ZW

更新日期：2016-09-28 00:00:00

abstract：:Recently developed quantitative and high-throughput technologies that allow automated and rapid screening of the whole genome, transcriptome and proteome have revolutionized the field of cancer genetics. At the same time, new challenges are met, e.g. the need for improved data analysis and standardization of tumor sam...

journal_title：Cancer letters

authors： De Preter K,Vandesompele J,Heimann P,Kockx MM,Van Gele M,Hoebeeck J,De Smet E,Demarche M,Laureys G,Van Roy N,De Paepe A,Speleman F

更新日期：2003-07-18 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Dendritic cell (DC) vaccine-based immunotherapy for glioblastoma multiforme (GBM) has shown apparent benefit in animal experiments and early-phase clinical trials, but the survival benefit is variable. In this work, we analyzed the mechanism of the potent antitumor immune response induced in vivo by tumor-associated a...

journal_title：Cancer letters

authors： Liu H,Chen L,Liu J,Meng H,Zhang R,Ma L,Wu L,Yu S,Shi F,Li Y,Zhang L,Wang L,Feng S,Zhang Q,Peng Y,Wu Q,Liu C,Chang X,Yang L,Uemura Y,Yu X,Liu T

更新日期：2017-12-28 00:00:00

abstract：:The malignant phenotype results from multiple genetic alterations, including the activation of oncogenes and inactivation of tumor suppressor genes. Activation of the Ki-ras oncogene has been implicated as an early event in the pathogenesis of lung adenocarcinomas in humans and experimental animal models. Previous stu...

journal_title：Cancer letters

authors： Mizesko MC,Grewe C,Grabner A,Miller MS

更新日期：2001-10-22 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assessed the expression a...

journal_title：Cancer letters

authors： Liang Z,Cao J,Tian L,Shen Y,Yang X,Lin Q,Zhang R,Liu H,Du X,Shi J,Zhang J

更新日期：2019-12-28 00:00:00

abstract：:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter...

journal_title：Cancer letters

authors： Richardson C

更新日期：2005-02-10 00:00:00

abstract：:Effects of the green tea catechins (GTCs) on the late promotion or progression stage of mammary gland carcinogenesis were examined in female Sprague-Dawley (SD) rats pretreated with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 84 7-week-old rats received a 50 mg/kg body weight intra-gastric dose of DMBA, and star...

journal_title：Cancer letters

authors： Hirose M,Mizoguchi Y,Yaono M,Tanaka H,Yamaguchi T,Shirai T

更新日期：1997-01-30 00:00:00

abstract：:Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistanc...

journal_title：Cancer letters

authors： Lin LC,Gao AC,Lai CH,Hsieh JT,Lin H

更新日期：2017-04-10 00:00:00

abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...

journal_title：Cancer letters

authors： Choo MK,Sakurai H,Koizumi K,Saiki I

更新日期：2005-12-08 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) is currently used therapeutically in the treatment of mammary and endometrial carcinomas. In order to develop a more potent and useful drug, we synthesized the novel compound, 9alpha-fluoromedoroxyprogesterone acetate (FMPA), by fluorinating MPA, and we also previously reported that F...

journal_title：Cancer letters

authors： Uchida M,Tsuboi H,Yamaji T,Murata N,Kohno T,Sugino E,Hibino S,Shimamura M,Oikawa T

更新日期：2000-06-01 00:00:00

abstract：:Viscum album L. (VAL) is a phytopreparation used in adjuvant cancer therapy with both immunostimulatory and DNA stabilizing properties at low drug concentrations and cytostatic/cytotoxic properties at higher concentrations. The present work examines the cytotoxic effects of VAL extracts produced from mistletoes grown ...

journal_title：Cancer letters

authors： Büssing A,Suzart K,Bergmann J,Pfüller U,Schietzel M,Schweizer K

更新日期：1996-01-19 00:00:00

abstract：:The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-ABP and PhIP exhibited moderate and weak tumorigenicity, respectively, in ad libitum fed mice; however, none of the ca...

journal_title：Cancer letters

authors： Von Tungeln LS,Bucci TJ,Hart RW,Kadlubar FF,Fu PP

更新日期：1996-07-12 00:00:00

abstract：:The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....

journal_title：Cancer letters

authors： Han Y,Li H,Guan Y,Huang J

更新日期：2016-09-01 00:00:00

abstract：:This aim of this study was to measure the typical free radical-induced products of DNA bases in cellular DNA of cervical cancer tissues directly irradiated by applying brachytherapy to the patients. Significant increases in the amounts of modified bases over the control level were observed in the samples isolated afte...

journal_title：Cancer letters

authors： Foksinski M,Jaruga P,Makarewicz R,Olinski R

更新日期：1998-10-23 00:00:00

abstract：:The etiology of prostatic adenocarcinoma remains unclear. Prostate cancer cells of varying metastatic potential and apoptotic resistance show altered expression of plasma membrane ion channels and unbalanced Ca2+ homeostasis. Ca(2+)-activated Cl(-) channels (CaCCs) are robustly expressed in epithelial cells and functi...

journal_title：Cancer letters

authors： Liu W,Lu M,Liu B,Huang Y,Wang K

更新日期：2012-12-29 00:00:00

abstract：:Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor growth and metastasis are largely uncharacterized. Here, we report that Bach1 expression was significantly higher in human epithelial ovarian cancer (EO...

journal_title：Cancer letters

authors： Han W,Zhang Y,Niu C,Guo J,Li J,Wei X,Jia M,Zhi X,Yao L,Meng D

更新日期：2019-03-31 00:00:00

abstract：:Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined ...

journal_title：Cancer letters

authors： Cohen JD,Strock DJ,Teik JE,Katz TB,Marcel PD

更新日期：1997-06-24 00:00:00

abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

journal_title：Cancer letters

authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

更新日期：2009-11-01 00:00:00

abstract：:YM529, a new third generation bisphosphonate, induced apoptosis of a human breast cancer cell line, MX-1. Cytotoxic activity of YM529 was more potent than that of incadronate. YM529 activated caspase-9, but not caspase-8, and induced the release of cytochrome c into cytosol. YM529 increased Bax expression and decrease...

journal_title：Cancer letters

authors： Nakajima H,Magae J,Tsuruga M,Sakaguchi K,Fujiwara I,Mizuta M,Sawai K,Yamagishi H,Mizuta N

更新日期：2007-08-08 00:00:00