Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy.

abstract：:Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

journal_title：Cancer letters

authors： Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

更新日期：2008-02-18 00:00:00

abstract：:Corynebacterium parvum was investigated in the response of rat Mc7 sarcoma to local waterbath hyperthermia. Heat treatment of 1-1.5 cm3 foot tumors at 43 degrees C for 2 h resulted in complete regression of 71% of the tumors. The Mc7 cure was reduced to 31% when the tumors were heated at 43 degrees C for 1.5 h. C. par...

journal_title：Cancer letters

authors： Shah SA

更新日期：1985-03-01 00:00:00

abstract：:Incubation of mouse epidermal cells (HEL-37) with phospholipase C (Clostridium perfringens) caused about a 50% decrease in the specific binding of [20-3H]phorbol-12,13-dibutyrate. Phospholipase C caused a decrease in the apparent number of binding sites from 2.86 X 10(5) to 1.21 X 10(5) per cell with little effect on ...

journal_title：Cancer letters

authors： Jones MJ,Murray AW

更新日期：1983-05-01 00:00:00

abstract：:TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...

journal_title：Cancer letters

authors： Park CY,Min KN,Son JY,Park SY,Nam JS,Kim DK,Sheen YY

更新日期：2014-08-28 00:00:00

abstract：:Ditercalinium (7-H-pyridocarbazole dimer), a prospective antitumor drug, is a bis-intercalator characterized by a very high affinity towards nucleic acids. Specificity of binding of this drug has been studied using spectroscopy and flow cytometry. The competition experiments between the drug and 4',6-diamidino-2-pheny...

journal_title：Cancer letters

authors： Kapuscinski J,Traganos F,Darzynkiewicz Z

更新日期：1988-11-01 00:00:00

abstract：:Monocrotaline is a representative naturally occurring genotoxic pyrrolizidine alkaloid. Metabolism of monocrotaline by liver microsomes of F344 female rats generated (+/-)6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP) and monocrotaline-N-oxide as major metabolites. Metabolism in the presence of triacetylea...

journal_title：Cancer letters

authors： Wang YP,Yan J,Beger RD,Fu PP,Chou MW

更新日期：2005-08-08 00:00:00

abstract：:A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, rel...

journal_title：Cancer letters

authors： Egan KM,Thompson PA,Titus-Ernstoff L,Moore JH,Ambrosone CB

更新日期：2003-09-10 00:00:00

abstract：:Malignant tumors remain a major health burden throughout the world, and effective therapeutic strategies are urgently needed. Combining gene therapy with chemotherapeutics in a single delivery system is more effective than co-treatment of cancer with individual delivery systems carrying either gene or drug. In this st...

journal_title：Cancer letters

authors： Dong D,Gao W,Liu Y,Qi XR

更新日期：2015-04-10 00:00:00

abstract：:Our previous studies have shown that norepinephrine induces the migratory activity of human PC-3 prostate, SW 480 colon and MDA-MB-468 breast carcinoma cells. In contrast to these results, we show here that human ES-2 ovarian carcinoma cells have a reduced migratory activity after norepinephrine treatment. This inhibi...

journal_title：Cancer letters

authors： Bastian P,Balcarek A,Altanis C,Strell C,Niggemann B,Zaenker KS,Entschladen F

更新日期：2009-02-18 00:00:00

abstract：:We induced tolerance to hexadecylphosphocholine (HePC) in the human epidermoid tumor cell line, KB. After 70 weeks of adaptation, the IC50 of HePC in the resistant cells KBr was 32-fold higher than in parental KB cells, and they were 30-fold more resistant to another ether lipid analogue, ET-18-OCH3. The KBr cells als...

journal_title：Cancer letters

authors： Fu D,Shi Z,Wang Y

更新日期：1999-08-03 00:00:00

abstract：:Liver cancer is an extraordinarily heterogeneous malignant disease among the tumors that have so far been identified. Hepatocellular carcinoma (HCC) arises most frequently in the setting of chronic liver inflammation and fibrosis, and takes a variety of course in individual patients to process to tumor. The risk facto...

journal_title：Cancer letters

authors： Li L,Wang H

更新日期：2016-09-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...

journal_title：Cancer letters

authors： Pflug BR,Zheng H,Udan MS,D'Antonio JM,Marshall FF,Brooks JD,Nelson JB

更新日期：2007-02-08 00:00:00

abstract：:Cisplatin is an anticancer agent that is effective against several types of cancer, including gastric cancer. However, its therapeutic application is limited by its toxicity in normal tissues and complications caused in patients. In this study, we attempted to clarify how triptolide, an active component extracted from...

journal_title：Cancer letters

authors： Li CJ,Chu CY,Huang LH,Wang MH,Sheu LF,Yeh JI,Hsu HY

更新日期：2012-06-28 00:00:00

abstract：:The analogs of benzidine were assay for mutagenicity using Salmonella typhimurium TA-98 and TA-100 and a mouse liver enzyme preparation. Only 4-aminobiphenyl produced both frameshift and base pair substitution mutations and 3,3'-dichlorobenzidine was the only compound which was mutagenic without the mammalian enzyme f...

journal_title：Cancer letters

authors： Lazear EJ,Louie SC

更新日期：1978-01-01 00:00:00

abstract：:Previously, we showed that hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, carbonic anhydrase IX (CA IX), and vascular endothelial growth factor (VEGF) were frequently coexpressed in tumor biopsies from patients of nasopharyngeal carcinoma (NPC) and were associated with poor outcome after radiotherapy. Here, we fur...

journal_title：Cancer letters

authors： Sung FL,Hui EP,Tao Q,Li H,Tsui NB,Lo YM,Ma BB,To KF,Harris AL,Chan AT

更新日期：2007-08-08 00:00:00

abstract：:The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...

journal_title：Cancer letters

authors： Thongsuksai P,Boonyaphiphat P,Sriplung H,Sudhikaran W

更新日期：2003-11-10 00:00:00

abstract：:Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...

journal_title：Cancer letters

authors： Boccardo F,Guarneri D,Zanardi S,Castellani P,Borsi L,Zardi L

更新日期：1986-12-01 00:00:00

abstract：:In a series of invasive ductal breast carcinoma, we investigated the status of chromosomal and intrachromosomal instability by fluorescence in situ hybridisation and determined the level of mRNA expression for two genes involved in the mitotic spindle checkpoint pathway, BUB1B and MAD2L1. All breast cancers demonstrat...

journal_title：Cancer letters

authors： Scintu M,Vitale R,Prencipe M,Gallo AP,Bonghi L,Valori VM,Maiello E,Rinaldi M,Signori E,Rabitti C,Carella M,Dallapiccola B,Altomare V,Fazio VM,Parrella P

更新日期：2007-09-08 00:00:00

abstract：:Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. W...

journal_title：Cancer letters

authors： Traulsen A,Pacheco JM,Dingli D

更新日期：2010-08-01 00:00:00

abstract：:In spite of much effort, no good markers have yet been found for predicting prognosis or response to therapy in advanced head and neck squamous cell carcinoma (HNSCCs) patients. beta-catenin, a protein involved in the cytoskeleton, cell-cell adhesion and gene transcription, is a factor associated with tumour progressi...

journal_title：Cancer letters

authors： Rodriguez-Pinilla M,Rodriguez-Peralto JL,Hitt R,Sanchez JJ,Sanchez-Verde L,Alameda F,Ballestin C,Sanchez-Cespedes M

更新日期：2005-12-08 00:00:00

abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

journal_title：Cancer letters

authors： Morgan WF,Sowa MB

更新日期：2015-01-01 00:00:00

abstract：:Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...

journal_title：Cancer letters

authors： Bubeník J,Lotzová E,Indrová M,Símová J,Jandlová T,Bubeníková D

更新日期：1992-03-15 00:00:00

abstract：:These studies examined the impact of dietary corn oil and its major constituent fatty acids on the occurrence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary DNA adducts. In study 1, rats were fed diets containing 5, 10 or 20% corn oil for 2 weeks prior to DMBA treatment (25 mg/kg). Mammary DNA adducts increa...

journal_title：Cancer letters

authors： Schaffer EM,Milner JA

更新日期：1996-09-10 00:00:00

abstract：:Previous studies have demonstrated that fibroblast growth factor 8b (FGF8b) is up-regulated in a large proportion of prostate cancer patients and that it plays a key role in prostate carcinogenesis. In this study, we designed and synthesized a gN helix domain derived short peptide (termed 8b-13) based on the analysis ...

journal_title：Cancer letters

authors： Li T,Luo W,He D,Wang R,Huang Y,Zeng X,Wang W,Chen X,Gao S,Yu Y,Li X,Wu X

更新日期：2013-10-10 00:00:00

abstract：:Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...

journal_title：Cancer letters

authors： Kubens BS,Zänker KS

更新日期：1998-09-11 00:00:00

abstract：:Intravenous methotrexate (MTX) therapy is widely used for treatment of various neoplastic diseases in children. The optimization of the MTX dose and/or the subsequent leucovorin rescue is based on pharmacokinetic data calculated from plasma concentrations collected after cessation of the MTX administration. The influe...

journal_title：Cancer letters

authors： Eksborg S,Albertioni F,Rask C,Beck O,Palm C,Schroeder H,Peterson C

更新日期：1996-11-29 00:00:00

abstract：:Approximately 25% of stage III colorectal cancer patients do not benefit from standard adjuvant chemotherapies. To identify biomarkers for nonresponders, fresh-frozen tissues of 19 nonresponders and 16 responders were analyzed with gene expression and microRNA arrays. Fifty-nine genes and 17 miRNAs were differentially...

journal_title：Cancer letters

authors： Dou R,Deng Y,Huang L,Fu S,Tan S,Wang L,Lian L,Fang L,Fan X,Jin G,Liu H,Wang J

更新日期：2013-08-09 00:00:00

abstract：:2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine (NPEOC-DAC), decitabine with a modification of the N4 position of the azacitidine ring can be used to inhibit DNA methyltransferase. This modification protects the azacitidine ring and can be cleaved by carboxylesterase to release decitabine. NPEOC-DAC was 23...

journal_title：Cancer letters

authors： Byun HM,Choi SH,Laird PW,Trinh B,Siddiqui MA,Marquez VE,Yang AS

更新日期：2008-08-08 00:00:00

abstract：:Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...

journal_title：Cancer letters

authors： Liu SH,Yu J,Creeden JF,Sutton JM,Markowiak S,Sanchez R,Nemunaitis J,Kalinoski A,Zhang JT,Damoiseaux R,Erhardt P,Brunicardi FC

更新日期：2020-10-28 00:00:00

abstract：:The over-expression of N-myc down-regulated gene 1 (NDRG1) in hepatocellular carcinoma (HCC) was previously reported to correlate with vascular invasion and patient survival. Our current study aims to elucidate its functions in HCC. We found that it lacked the tumorigenic ability to promote soft agar colony formation ...

journal_title：Cancer letters

authors： Yan X,Chua MS,Sun H,So S

更新日期：2008-04-08 00:00:00