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RAD51, genomic stability, and tumorigenesis.

Abstract：

:Genomic instability is characteristic of malignant cells, and a strong correlation exists between abnormal karyotype and tumorigenicity. Increased expression of the homologous recombination and DNA repair protein Rad51 has been reported in immortalized cell lines and multiple primary tumor cell types which could alter recombination pathways to contribute to the chromosomal rearrangements found in these cells. In addition, Rad51 participates in a complex network of interactions that includes DNA damage sensors, tumor suppressors, and cell cycle and apoptotic regulators, and mutation of many of these proteins have also been associated with tumor initiation or progression. Insights into the connection between disregulated Rad51 and malignant phenotype indicate that Rad51 is a potential target for new anti-cancer regimens including those that use siRNA technology.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Richardson C

doi

10.1016/j.canlet.2004.08.009

keywords:

subject

Has Abstract

pub_date

2005-02-10 00:00:00

pages

127-39

issue

2

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(04)00639-1

journal_volume

218

pub_type

杂志文章,评审

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