Aiming at the sweet side of cancer: aberrant glycosylation as possible target for personalized-medicine.

Abstract:

:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often leads to aberrant expression of sialic acids (Sia) that cap glycan-chains. Additionally, dietary intake of the non-human Sia N-glycolylneuraminic acid (Neu5Gc) leads to natural metabolic-glycoengineering of human carcinomas that accumulate and express Neu5Gc. This Sia provokes a polyclonal anti-Neu5Gc xeno-autoantibodies response that can exacerbate cancer. This review highlights cancer-associated changes in Sia expression and their potential for personalized-theranostics.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Padler-Karavani V

doi

10.1016/j.canlet.2013.10.005

subject

Has Abstract

pub_date

2014-09-28 00:00:00

pages

102-12

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(13)00732-5

journal_volume

352

pub_type

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