Garlic and associated allyl sulfur components inhibit N-methyl-N-nitrosourea induced rat mammary carcinogenesis.


:Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble diallyl disulfide (DADS), on the incidence of mammary tumorigenesis induced by N-methyl-N-nitrosourea (MNU). Female Sprague-Dawley rats were fed semi-purified casein based diets with or without supplements of garlic powder(20g/kg), SAC (57 micromol/kg) or DADS (57 micromol/kg) for 2 weeks prior to treatment with MNU (15 mg/kg body wt). Garlic powder, SAC and DADS supplementation significantly delayed the onset of mammary tumors compared to rats receiving the unsupplemented diet. Tumor incidence 23 weeks after MNU treatment was reduced by 76, 41 and 53% in rats fed garlic, SAC and DADS, respectively, compared to controls (P<0.05). Total tumor number was reduced 81, 35 and 65% by these supplements, respectively (P<0.05). In a separate study the quantity of mammary DNA alkylation occurring 3 h after MNU treatment was reduced in rats fed garlic, SAC or DADS (P<0.05). Specifically, O(6)-methylguanine adducts were reduced by 27, 18 and 23% in rats fed supplemental garlic, SAC and DADS, respectively, compared to controls. N(7)-Methylguanine adducts decreased by 48, 22 and 21% respectively, compared to rats fed the control diet. These studies demonstrate that garlic and associated allyl sulfur components, SAC and DADS, are effective inhibitors of MNU-induced mammary carcinogenesis.


Cancer Lett


Cancer letters


Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA




Has Abstract


1996-04-19 00:00:00














  • Preferential enlargement of leukemia cells using cytoskeletal-directed agents and cell cycle growth control parameters to induce sensitivity to low frequency ultrasound.

    abstract::Sonodynamic therapy (SDT) is a form of ultrasound therapy that has been shown to preferentially damage malignant cells based on the relatively enlarged size and altered cytology of neoplastic cells in comparison to normal cells. This study sought to determine whether cytoskeletal-directed agents that either disrupt (c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Trendowski M,Wong V,Zoino JN,Christen TD,Gadeberg L,Sansky M,Fondy TP

    更新日期:2015-05-01 00:00:00

  • Therapeutic potential of targeted multifunctional nanocomplex co-delivery of siRNA and low-dose doxorubicin in breast cancer.

    abstract::Malignant tumors remain a major health burden throughout the world, and effective therapeutic strategies are urgently needed. Combining gene therapy with chemotherapeutics in a single delivery system is more effective than co-treatment of cancer with individual delivery systems carrying either gene or drug. In this st...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Dong D,Gao W,Liu Y,Qi XR

    更新日期:2015-04-10 00:00:00

  • How to treat CML patients in the tyrosine kinase inhibitors era? From imatinib standard dose to second generation drugs front-line: unmet needs, pitfalls and advantages.

    abstract::Imatinib has revolutionized treatment strategies for chronic myeloid leukemia patients: long-term overall survival was reported to be up to 80% at 8 years of follow-up in respondent patients. Despite the straightforward results obtained, it has been estimated a failure rate per year of 2-4%. Several attempts to improv...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Breccia M,Alimena G

    更新日期:2012-09-28 00:00:00

  • The role of basic fibroblast growth factor in glioblastoma multiforme and glioblastoma stem cells and in their in vitro culture.

    abstract::Glioblastoma multiforme (GBM) is the most malignant form of central nervous system tumor, and current therapies are largely ineffective at treating the cancer. Developing a more complete understanding of the mechanisms controlling the tumor is important in order to explore new possible treatment options. It is specula...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Haley EM,Kim Y

    更新日期:2014-04-28 00:00:00

  • Fibronectin concentration in the plasma of patients with malignant and benign breast disease.

    abstract::Fibronectin concentration was determined in plasma from 97 patients with benign or malignant breast disease and from 62 controls. Median plasma fibronectin concentration (microgram FN/ml plasma) appeared to be significantly higher in patients with non-metastatic or metastatic breast cancer as compared to age-matched c...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Boccardo F,Guarneri D,Zanardi S,Castellani P,Borsi L,Zardi L

    更新日期:1986-12-01 00:00:00

  • Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis.

    abstract::The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

    更新日期:2009-11-01 00:00:00

  • Mutagenic virus replication in human tumor cells.

    abstract::Herpes simplex virus was grown in different lines of human tumor and normal cells. The progeny virus was assayed for resistance to iododeoxycytidine, an indicator of a forward mutation in the virus genome. Virus grown in cells from 4 of 5 tumor lines demonstrated greater fractions mutated to iododeoxycytidine resistan...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bockstahler LE,Lytle CD,Lubiniecki AS,Cantwell JM,Galleshaw JA

    更新日期:1982-11-01 00:00:00

  • Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.

    abstract::Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation. Telomerase activity or hTERT expression has thus served as diagnostic and/or prognostic markers in different types of human mal...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li W,Li L,Liu Z,Liu C,Liu Z,Strååt K,Björkholm M,Jia J,Xu D

    更新日期:2008-02-18 00:00:00

  • The metabolic landscape of urological cancers: New therapeutic perspectives.

    abstract::Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the hi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

    更新日期:2020-05-01 00:00:00

  • Pancreatic carcinogenicity of N-nitrosobis(2-oxopropyl)-amine in diabetic and non-diabetic Chinese hamsters.

    abstract::To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg bo...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Bell RH Jr,Pour PM

    更新日期:1987-02-01 00:00:00

  • Low-frequency electromagnetic radiation enhances the induction of rat mammary tumors by nitrosomethyl urea.

    abstract::Low-frequency electromagnetic fields enhance the induction of mammary gland tumors in rats using nitrosomethyl urea. The incidence of tumors depended on the duration of exposure to static (dc) and variable (ac) magnetic fields. Variable magnetic fields induced mammary gland cancer much more frequently than static ones...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Beniashvili DS,Bilanishvili VG,Menabde MZ

    更新日期:1991-12-09 00:00:00

  • Carcinogenesis by methylbenzylnitrosamine near the squamocolumnar junction and methylamylnitrosamine metabolism in the mouse forestomach.

    abstract::We repeated and extended a 1973 study by Sander and Schweinsberg on forestomach tumorigenesis in mice by methylbenzylnitrosamine (MBZN). Groups of 80 adult CD-1 mice of both sexes received 96 mg/kg of MBZN subdivided into 24 doses of 4 mg/kg, 12 doses of 8 mg/kg or 6 doses of 16 mg/kg (groups 1-3, respectively). The m...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Schneider P,Hinrichs S,Zulim R,Towery R,Morris C,Mirvish SS

    更新日期:1996-04-19 00:00:00

  • Expression of a specific mouse germ cell nuclear antigen (GCNA1) by early embryonic testicular teratoma cells in 129/Sv-Sl/+ mice.

    abstract::Spontaneous testicular teratomas which develop at a high rate in 129/Sv-Sl/+ mice are thought to be derived from germ cells. The teratomas present initially as groups of atypical germ-like cells within seminiferous cords of the 15.5 days post coitum (dpc) embryonic testes. These pluripotent teratoma stem cells are cap...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang D,Enders GC

    更新日期:1996-02-27 00:00:00

  • Fibronectin promotes cell proliferation and invasion through mTOR signaling pathway activation in gallbladder cancer.

    abstract::Fibronectin (FN), a heterodimeric glycoprotein overexpressed in several types of tumors, has been implicated in cancer progression via the activation of integrin-mediated pro-oncogenic pathways. The FN level in human bile fluid is dramatically increased in malignant biliary diseases; however, FN expression and its bio...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Cao Y,Liu X,Lu W,Chen Y,Wu X,Li M,Wang XA,Zhang F,Jiang L,Zhang Y,Hu Y,Xiang S,Shu Y,Bao R,Li H,Wu W,Weng H,Yen Y,Liu Y

    更新日期:2015-05-01 00:00:00

  • Fetal microchimerism and cancer.

    abstract::The acquisition and persistence of fetal microchimerism, small numbers of genetically disparate cells from the fetus in the mother, is now a well-recognized consequence of normal pregnancy. Fetal microchimerism has been associated with several classical autoimmune diseases, but its role in normal health remains undefi...

    journal_title:Cancer letters

    pub_type: 杂志文章,评审


    authors: Gadi VK

    更新日期:2009-04-08 00:00:00

  • Transcriptionally active non-ligand binding oestrogen receptors in breast cancer.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Marsigliante S,Greco S,Biscozzo L,Barker S,Baker V,Giuseppe L,Vinson GP,Storelli C

    更新日期:1992-10-21 00:00:00

  • Thymosin alpha(1) application augments immune response and down-regulates tumor weight and organ colonization in BALB/c-mice.

    abstract::The immunomodulatory and antimetastatic/antitumor activity of thymosin alpha(1) (Talpha(1)) was evaluated in BALB/c-mice. Daily subcutaneous application (7 consecutive days, 0.01-10 microg of Talpha(1)/injection per mouse) upregulated the number of thymocytes and peripheral blood cells in tumor bearing mice. To check ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Beuth J,Schierholz JM,Mayer G

    更新日期:2000-10-16 00:00:00

  • Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide.

    abstract::N'-Nitrosonornicotine (NNN) or N'-nitrosonornicotine-1-N-oxide (NNN-1-N-oxide), one of its metabolites, was added to the drinking water (0.012% for 36 weeks) of groups of male and female F344 rats or to the drinking water (0.016% for 31 weeks) of groups of male and female Syrian golden hamsters. All rats treated with ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hecht SS,Young R,Maeura Y

    更新日期:1983-10-01 00:00:00

  • Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization.

    abstract::By comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Wang Y,He QY,Tsao SW,Cheung YH,Wong A,Chiu JF

    更新日期:2008-07-08 00:00:00

  • MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3.

    abstract::The traditional anti-angiogenic cancer therapy could trigger hypoxia induced factor (HIF) response, leading to "reactive resistance" to chemotherapy. Simultaneously inhibiting both angiogenesis and tumorigenesis would be ideal to overcome this limitation. MicroRNAs (miRNAs) are increasingly explored as new agents for ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Li Y,Cai B,Shen L,Dong Y,Lu Q,Sun S,Liu S,Ma S,Ma PX,Chen J

    更新日期:2017-07-01 00:00:00

  • Truncated somatostatin receptor variant sst5TMD4 confers aggressive features (proliferation, invasion and reduced octreotide response) to somatotropinomas.

    abstract::The GH/IGF1 response of somatotropinomas to somatostatin analogues (SSA) is associated with their pattern of somatostatin receptor (sst1-sst5) expression. Recently, we demonstrated that expression of a truncated sst5-variant (sst5TMD4) can influence the secretory response of somatotropinomas to SSA-therapy; however, i...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Luque RM,Ibáñez-Costa A,Neto LV,Taboada GF,Hormaechea-Agulla D,Kasuki L,Venegas-Moreno E,Moreno-Carazo A,Gálvez MÁ,Soto-Moreno A,Kineman RD,Culler MD,Gahete MD,Gadelha MR,Castaño JP

    更新日期:2015-04-10 00:00:00

  • Autocrine TGF-β1/miR-200s/miR-221/DNMT3B regulatory loop maintains CAF status to fuel breast cancer cell proliferation.

    abstract::Cancer-associated fibroblasts (CAFs) remain active even in the absence of cancer cells. However, the molecular mechanism underlying the sustained active status of CAFs is largely unrevealed. We found that in CAFs, DNMT3B was not only a target of miR-200b, miR-200c and miR-221, but was able to induce DNA methylation of...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tang X,Tu G,Yang G,Wang X,Kang L,Yang L,Zeng H,Wan X,Qiao Y,Cui X,Liu M,Hou Y

    更新日期:2019-06-28 00:00:00

  • Dose-response study of MeIQx carcinogenicity in F344 male rats.

    abstract::The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

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  • Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Foksinski M,Jaruga P,Makarewicz R,Olinski R

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  • Determination of DNA topoisomerase II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Stammler G,Sauerbrey A,Volm M

    更新日期:1994-09-15 00:00:00

  • Influence of lithium on mammary tumor growth in vivo.

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    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Ziche M,Maiorana A,Oka T,Gullino PM

    更新日期:1980-05-01 00:00:00

  • Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice.

    abstract::Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Connolly JM,Rose DP

    更新日期:1998-10-23 00:00:00

  • Antitumor activity of a novel nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) against murine and human tumors.

    abstract::The antitumor effects of 2'-C-cyano-2'-deoxy-1-beta-D- arabinofuranosylcytosine (CN-DAC), a synthetic 1-beta-D-arabinofuranosyl-cytosine (ara-C) derivative, were examined and compared with that of ara-C in murine tumors and in various human tumors using three different chemosensitivity tests. CNDAC extended the life s...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tanaka M,Matsuda A,Terao T,Sasaki T

    更新日期:1992-05-30 00:00:00

  • Increased sensitivity to indomethacin of mice bearing the BCL1-leukemia.

    abstract::Indomethacin is a non-steroidal anti-inflammatory agent that inhibits prostaglandin synthesis. Administration of indomethacin, in doses which were non-toxic to normal BALB/c mice, to mice bearing the BCL1 leukemia resulted in increased mortality of these animals. This effect was only observed if the indomethacin was a...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Hart DA

    更新日期:1984-06-01 00:00:00

  • Nitrosation products from the plant Ephedra altissima and their potential endogenous formation.

    abstract::The plant species Ephedra is commonly used in both folk medicine and for the preparation of health teas. Nitrosation of a tea made from Ephedra altissima yielded N-nitrosoephedrine (NEP), N-nitrosopseudoephedrine (NPEP), N-nitrosoproline (NPRO), N-nitrosomethylbenzylamine (NMBA), trace quantities of 2 unidentified non...

    journal_title:Cancer letters

    pub_type: 杂志文章


    authors: Tricker AR,Wacker CD,Preussmann R

    更新日期:1987-05-01 00:00:00