Abstract:
:To better understand causative relations of smoking to lung adenocarcinomas, the frequency of loss of heterozygosity (LOH) of all autosomal chromosomes was compared among the three grades of histological differentiation with 119 pulmonary adenocarcinomas (AC) and 41 squamous cell carcinomas (SCC), using Southern blotting. The fractional allelic loss (FAL) values, defined as (number of chromosome arms with LOH)/(number of informative arms), and smoking index (a product of number of cigarettes per day and duration in years) for all ACs were 0.19 and 520 whereas those for SCCs were 0.34 and 1,160, respectively. Those for well- (n=33), moderately (n=63) and poorly (n=23) differentiated ACs were 0.100, 0.197, 0.295 and 310, 480, 1,010, respectively. These results showed that less differentiated ACs are more similar to SCC in terms of LOH frequency and smoking.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Ishikawa Y,Furuta R,Miyoshi T,Satoh Y,Okumura S,Nakagawa K,Tsuchiya Edoi
10.1016/s0304-3835(02)00383-xkeywords:
subject
Has Abstractpub_date
2002-12-10 00:00:00pages
47-51issue
1-2eissn
0304-3835issn
1872-7980pii
S030438350200383Xjournal_volume
187pub_type
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