Abstract:
:In the current study we examined the regulation of Bak, a death promoter of an apoptotic pathway, in the human breast cancer cell line MCF-7. We observed a time-dependent increase in both Bak mRNA and protein levels which appeared to correlate well with the increase in cell density. We also found that treatment of cells with 17beta-estradiol resulted in inhibition of the time-dependent increases in Bak mRNA and protein. The effects of estradiol appeared to be via estrogen receptor as treatment of cells with progesterone did not effect Bak expression. Our study provides additional molecular evidence for (1) a link between apoptosis pathways and cell-cell and/or cell-cell matrix interactions and (2) a role for estradiol in the modulation of signals between apoptosis pathways and cell-cell and/or cell-cell matrix interactions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Leung LK,Do L,Wang TTdoi
10.1016/s0304-3835(97)00430-8subject
Has Abstractpub_date
1998-02-13 00:00:00pages
47-52issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(97)00430-8journal_volume
124pub_type
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