Abstract:
:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the high proliferative rates and macromolecule biosynthesis of cancer cells. Despite advances in therapy, urothelial tumors still exhibit high recurrence and mortality rates, especially in advanced stages of disease. These tumors harbor gene mutations and expression patterns which play an important role in metabolic reprogramming. Taking into account the unique metabolic features underlying carcinogenesis in these cancers, new and promising therapeutic targets based on metabolic alterations must be considered. Furthermore, the combination of metabolic inhibitors with conventional targeted therapies may improve effectiveness of treatments. This review will summarize the metabolic alterations present in urological tumors and the results with metabolic inhibitors currently available.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo Cdoi
10.1016/j.canlet.2020.02.034subject
Has Abstractpub_date
2020-05-01 00:00:00pages
76-87eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30103-8journal_volume
477pub_type
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