The metabolic landscape of urological cancers: New therapeutic perspectives.

Abstract:

:Deregulation of cell metabolism is an established cancer hallmark that contributes to tumor initiation and progression, as well as tumor heterogeneity. In solid tumors, alterations in different metabolic pathways, including glycolysis, pentose phosphate pathway, glutaminolysis and fatty acid metabolism, support the high proliferative rates and macromolecule biosynthesis of cancer cells. Despite advances in therapy, urothelial tumors still exhibit high recurrence and mortality rates, especially in advanced stages of disease. These tumors harbor gene mutations and expression patterns which play an important role in metabolic reprogramming. Taking into account the unique metabolic features underlying carcinogenesis in these cancers, new and promising therapeutic targets based on metabolic alterations must be considered. Furthermore, the combination of metabolic inhibitors with conventional targeted therapies may improve effectiveness of treatments. This review will summarize the metabolic alterations present in urological tumors and the results with metabolic inhibitors currently available.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Miranda-Gonçalves V,Lameirinhas A,Henrique R,Baltazar F,Jerónimo C

doi

10.1016/j.canlet.2020.02.034

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

76-87

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(20)30103-8

journal_volume

477

pub_type

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