Abstract:
:Photodynamic action has been advocated as an alternative treatment of tumors but the most common used dyes, hematoporphyrin derivatives, are substrate for P-glycoprotein. This study investigated the MDR-reverting properties of methylene blue (MB) and compared the sensitivity to its photodynamic action (PDA) in five cell lines that either express or do not express the MDR phenotype. MB was able to revert the MDR phenotype and there was no difference in sensitivity to MB-PDA between MDR and non-MDR cells, suggesting that MB has the advantage of being used simultaneously as a MDR reverser and a photodynamic agent.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Trindade GS,Farias SL,Rumjanek VM,Capella MAdoi
10.1016/s0304-3835(99)00408-5keywords:
subject
Has Abstractpub_date
2000-04-14 00:00:00pages
161-7issue
2eissn
0304-3835issn
1872-7980pii
S0304383599004085journal_volume
151pub_type
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