Abstract:
:Cancer results from genetic alterations in intracellular signaling pathways, which normally orchestrate the execution of developmental programs and the organismic response to extrinsic factors. Mutations in upstream activators and components of the cytoplasmic (Ras-Raf MEK-ERK) cascade frequently occur in tumors. In vitro and in vivo studies have shown that isolated activation of this pathway is both, necessary and sufficient for transformation. During the last years two new groups of related kinases have joined the ranks of mitogen-activated protein kinases, stress-activated protein kinases/Jun N-terminal kinases and p38. Their activation not only occurs during cellular responses to unphysiological stimuli but also downstream of cytokine and pathogen receptors and has been observed in tumors. In this article we will review the role of stress kinases in cancer, and discuss the mechanisms through which they regulate the transformation process.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Rennefahrt U,Janakiraman M,Ollinger R,Troppmair Jdoi
10.1016/j.canlet.2004.08.003keywords:
subject
Has Abstractpub_date
2005-01-10 00:00:00pages
1-9issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(04)00624-Xjournal_volume
217pub_type
杂志文章,评审相关文献
CANCER LETTERS文献大全abstract::Inhibition of 5-Lox induces apoptosis in prostate cancer cells by inactivating PKCε which is prevented by 5-oxoETE, and activators of PKCε prevent 5-Lox inhibition-induced apoptosis, suggesting that 5-Lox metabolites exert survival signaling via PKCε. However, mechanisms by which 5-Lox metabolites activate PKCε are no...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.04.027
更新日期:2013-08-09 00:00:00
abstract::Interferons are able to enhance the expression of carcinoembryonic antigen (CEA) on tumour cells, allowing improved tumour targeting. In this report the hypothesis is tested that combinations of cytokines may further increase the tumour antigen expression. The combination of both IFN-gamma and IFN-alpha with interleuk...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00007-5
更新日期:1999-05-03 00:00:00
abstract::Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits, which plays an essential role in cancer cell hypoxia adaptation, glycolysis, and angiogenesis. Normally, HIF-1alpha protein, the dominant subunit of HIF-1, is accumulated in nuclei when cells are exposed to ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(02)00053-8
更新日期:2002-07-26 00:00:00
abstract::In the present study, the question of whether the ubiquitous environmental pollutant, 1-nitropyrene (1-NP), can induce gamma-glutamyltranspeptidase (GGT)-positive foci, an early lesion occurring during hepatocarcinogenesis, when given orally to F344 rats was examined. Significant induction of GGT-positive foci was obs...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90031-1
更新日期:1989-04-01 00:00:00
abstract::This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HR...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.12.015
更新日期:2014-07-10 00:00:00
abstract::Chromosomal assignment of human transcribed sequences has been done mainly by high throughput genome analysis in specialized genome centres and, in a more classical fashion, by fluorescence in-situ hybridization (FISH) analysis. Not every laboratory has the ability to map cDNAs by FISH analysis. We here report a rapid...
journal_title:Cancer letters
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1016/s0304-3835(00)00690-x
更新日期:2001-01-10 00:00:00
abstract::Cytological appearance of fragile sites as non-staining gaps in metaphase chromosomes suggests an abnormality in chromatin structure. Studies of fragile sites at three levels of chromosome organization: (1) examining the ability of DNA derived from fragile sites to form nucleosomes-the basic structural element of chro...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2005.07.040
更新日期:2006-01-28 00:00:00
abstract::Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.06.047
更新日期:2005-11-18 00:00:00
abstract::It is known that the ingestion of cooked meat which contains carcinogenic heterocyclic amines causes increase in urinary mutagenicity in humans. Using 6 healthy non-smokers, we examined the effect of 3-week oral administration of Lactobacillus casei (bacilli commonly present in yoghurt), on the urinary mutagenicity de...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(93)90261-7
更新日期:1993-09-30 00:00:00
abstract::We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E receptor subtype EP(1) using a genetic approach in EP(1)-knockout mice and a pharmacological approach with the EP(1) selective antagonist, ONO-8711. In the present study, we examined the effect...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00440-7
更新日期:2000-08-01 00:00:00
abstract::Transfection of the estrogen-dependent and poorly invasive MCF-7 human breast cancer cell line so that it stably overexpressed 12-lipoxygenase and secreted high levels of 12-hydroxyeicosatetraenoic acid when cultured with arachidonate resulted in rapid growth in athymic nude mice when compared with the parental line. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00171-2
更新日期:1998-10-23 00:00:00
abstract::PM2 DNA, forms I and II, were chemically modified with the ultimate carcinogen N-acetoxy-2-acetylaminofluorene. The products were subjected to 3 analytical procedures: (i) buoyant density centrifugation in the presence of the intercalating dyes ethidium bromide or propidium diiodide; (ii) agarose gel electrophoresis: ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(80)90151-2
更新日期:1980-02-01 00:00:00
abstract::In our joint project in the search for anti-tumor promoters from natural plant sources, we carried out a primary screening of 12 phenylpropanoids isolated from Boronia pinnata Sm. (Rutaceae) by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradeca...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00147-0
更新日期:1999-07-19 00:00:00
abstract::Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.07.025
更新日期:2020-10-28 00:00:00
abstract::In the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the glioma-associated oncogene homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma (RMS) and med...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.08.012
更新日期:2019-11-28 00:00:00
abstract::YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2016.02.022
更新日期:2016-06-28 00:00:00
abstract::The efficacy and mechanism of action of cisplatin and gemcitabine were investigated in a panel of neuroblastoma cell lines and multicellular tumor spheroids. In neuroblastoma spheroids, the combination of cisplatin and gemcitabine induced a complete cytostasis at clinical relevant concentrations. A synergistic effect ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.12.016
更新日期:2012-06-01 00:00:00
abstract::The cell transforming ability of asbestos dust was investigated using C3H10T 1/2 murine fibroblasts. In a series of experiments both crocidolite and amosite caused no increase in the number of transformed foci over that seen in cultures from untreated cells. The dusts, were, however, capable of augmenting the oncogeni...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90071-x
更新日期:1983-03-01 00:00:00
abstract::Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and re...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2020.01.034
更新日期:2020-04-10 00:00:00
abstract::We present the data of 105 serum samples from 20 patients suffering from cervical cancer. Mean serum levels of basic fibroblast growth factor (bFGF) in patients with or without tumor present were 31.3 +/- 32.1 (minimum 0, maximum 156.7) pg/ml and 4.8 +/- 6.8 (minimum 0, maximum 29.6) pg/ml, respectively (P = 0.0001). ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(95)03853-o
更新日期:1995-08-01 00:00:00
abstract::Tobacco-specific N-nitrosamines (TSNA) are the most abundant carcinogens identified in tobacco and its smoke. Reducing their levels in tobacco products and especially in cigarette smoke is, therefore, a primary goal towards minimizing the carcinogenic burden of the tobacco consumer. This study delineates the mechanism...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90173-8
更新日期:1983-01-01 00:00:00
abstract::Monitoring angiogenesis is potentially an effective strategy for the early detection of cancer. In this study, early detection was achieved by evaluating blood vessel density in the liver using a three-dimensional contrast-enhanced high-frequency ultrasound (CE-HFUS) system and Sonazoid microbubbles. Three-dimensional...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2013.06.006
更新日期:2013-10-10 00:00:00
abstract::Human cancer cells in vitro (NHIK 3025), derived from a carcinoma in situ are inactivated when exposed to visible light in the presence of hematoporphyrin. Irradiation at 4 degrees C results in much more efficient inactivation than irradiation at 37 degrees C. Furthermore, a given total light dose is more efficient wh...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(79)80090-7
更新日期:1979-05-01 00:00:00
abstract::The in vitro sensitivities to differentiating agents of a murine neuroblastoma cell line (N18) and a selected variant cell line (N18-LM5) were examined. In addition, the sensitivities to differentiating agents of cells from spontaneous metastases produced by N18 cells were examined. When N18 cells (1 X 10(5) cells/mou...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(83)90133-7
更新日期:1983-05-01 00:00:00
abstract::Diet is one of the elements that may influence the development of lung cancer. To ascertain the relationship between meat and fish consumption and the appearance of this disease, a case-control study was conducted on a population in Galicia (NW Spain), with a sample of 295 cases and 322 controls. All cases had histolo...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.12.008
更新日期:2007-07-08 00:00:00
abstract::Dinitropyrenes are mutagenic environmental pollutants. Of these compounds, 1,6-dinitropyrene is a potent tumorigen while 1,3-dinitropyrene appears to be weakly or non-tumorigenic. Two-electron reduction of dinitropyrenes yields nitro-nitrosopyrenes, which have been shown previously to be the major aerobic metabolites ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(92)90215-h
更新日期:1992-07-31 00:00:00
abstract::Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting C...
journal_title:Cancer letters
pub_type: 杂志文章,多中心研究
doi:10.1016/s0304-3835(99)00104-4
更新日期:1999-07-01 00:00:00
abstract::As a promising method for local tumor treatment, nanosecond pulsed electric field (nsPEF) ablation elicits a potent anti-tumor immune response. However, the mechanism of the nsPEF-mediated anti-tumor immune response and its effects on the tumor microenvironment remains unclear. Here, we demonstrated that nsPEF treatme...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.09.015
更新日期:2020-12-28 00:00:00
abstract::Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and functi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2006.02.007
更新日期:2007-02-08 00:00:00
abstract::D-Tryptophan-6-luteinizing hormone-releasing hormone (D-Trp6-LH-RH) applied from day -8 to day +15 before and after administration of the nitrosourea analog, N,N'-bis[N-(2-chloroethyl)-N-nitrosocarbamoyl]cysteamine (CNCC), favored bone marrow restoration, as independently evaluated by 3 observers in a double-blind fas...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(84)80036-1
更新日期:1984-12-01 00:00:00