Abstract:
:To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable lines CAL51 and SK-UT-1B. The number of de novo, non-clonal chromosome rearrangements was also significantly higher in CH1 than CAL51 and SK-UT-1B (p=0.001). This study reveals multiple genomic abnormalities in tumors with near normal karyotypes and suggests that genomic instability may be essential in cancer development.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Mao X,Young BD,Chaplin T,Shipley J,Lu YJdoi
10.1016/j.canlet.2008.03.003subject
Has Abstractpub_date
2008-08-18 00:00:00pages
49-54issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(08)00190-0journal_volume
267pub_type
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