当前位置： SCI文献检索 > CANCER LETTERS期刊下所有文献 > The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer.

The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer.

Abstract：

:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy control subjects were genotyped for the GNB3 polymorphism to analyze its role for breast cancer. Prevalences of GNB3 CC, CT and TT genotypes were similar among patients (49.7, 39.8, 10.5%) and controls (50.1, 42.4, 7.5%, P = 0.25). The GNB3 genotype was furthermore not linked to tumor size, histological grading, estrogen or progesterone receptor status and age at diagnosis. In an exploratory analysis, carriage of a 825-T allele was associated with a longer metastasis-free period in patients with primary low-grade breast cancer, but not in those with primary high-grade breast cancer (Cox regression, P = 0.025). We conclude that the GNB3 825C>T polymorphism does not appear to be associated with breast cancer risk, but may influence development of metastasis in low-grade tumors.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

doi

10.1016/j.canlet.2003.11.030

keywords:

subject

Has Abstract

pub_date

2004-03-31 00:00:00

pages

59-62

issue

1

eissn

0304-3835

issn

1872-7980

pii

S0304383503008243

journal_volume

206

pub_type

杂志文章

相关文献

CANCER LETTERS文献大全
  • Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2.

    abstract：:Two hepatoma cell lines were incubated for 72 h with ATRA and its analog 13cisRA and according to MTT assay, Hep3B cells were highly susceptible whereas HepG2 cells were more resistant to the treatment. At the high concentration of 166 microM, retinoids were able to induce apoptosis in both cell lines and the highest ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2005.06.047

    authors： Arce F,Gätjens-Boniche O,Vargas E,Valverde B,Díaz C

    更新日期：2005-11-18 00:00:00

  • Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses.

    abstract：:Ashwagandha, also called as "Queen of Ayurveda" and "Indian ginseng", is a commonly used plant in Indian traditional medicine, Ayurveda. Its roots have been used as herb remedy to treat a variety of ailments and to promote general wellness. However, scientific evidence to its effects is limited to only a small number ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.11.037

    authors： Widodo N,Takagi Y,Shrestha BG,Ishii T,Kaul SC,Wadhwa R

    更新日期：2008-04-08 00:00:00

  • Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship.

    abstract：:In order to adapt to the reduced availability of nutrients and oxygen in the tumor microenvironment and the increased requirements of energy and building blocks necessary for maintaining their high proliferation rate, malignant cells undergo metabolic changes that result in an increased production of lactate, nitric o...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2017.10.037

    authors： Netea-Maier RT,Smit JWA,Netea MG

    更新日期：2018-01-28 00:00:00

  • The TGFβ-induced lncRNA TBILA promotes non-small cell lung cancer progression in vitro and in vivo via cis-regulating HGAL and activating S100A7/JAB1 signaling.

    abstract：:Long non-coding RNAs (lncRNAs) play critical roles in multiple cellular processes in non-small cell lung cancer (NSCLC); however, the involvement of lncRNAs in the transforming growth factor-beta (TGFβ) signaling pathway, the critical tumor cell epithelial-mesenchymal transition (EMT) and metastasis pathway, remains p...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.06.013

    authors： Lu Z,Li Y,Che Y,Huang J,Sun S,Mao S,Lei Y,Li N,Sun N,He J

    更新日期：2018-09-28 00:00:00

  • Differential effects of butylated hydroxyanisole on metabolism of aflatoxin B1 in vitro by liver and lung microsomes.

    abstract：:Growing epidemiological evidence points out the carcinogenic hazard of inhaled aflatoxin B1 (AFB1) to the pulmonary system. Metabolism of AFB1 by lung microsomes and its binding to calf thymus DNA are reported for the first time in this paper. In addition, the ability of dietary butylated hydroxyanisole (BHA) to modul...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90261-3

    authors： Allameh A,Saxena M,Raj HG

    更新日期：1988-05-01 00:00:00

  • In vivo efficacy of HAT therapy against transplantable murine myelomas resistant to purine analogs.

    abstract：:The therapeutic efficacy of antineoplastic purine analogs can be jeopardized by the emergence of drug-resistant mutant subpopulations of tumor cells. To determine whether such mutant populations might be eradicable in vivo with the type of HAT combination (hypoxanthine + an antifolate + thymidine) known to be selectiv...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(86)90152-7

    authors： Moolten FL

    更新日期：1986-06-01 00:00:00

  • MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.

    abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.01.030

    authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

    更新日期：2014-05-28 00:00:00

  • TGF-beta-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells.

    abstract：:We have previously shown that transforming growth factor (TGF)-beta up-regulates matrix metalloproteinase (MMP)-2 leading to the induction of oncogenic signaling in preneoplastic MCF10A human breast epithelial cells. The present study investigated the mechanism of transcriptional regulation of MMP-2 by TGF-beta in MCF...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2006.12.016

    authors： Kim ES,Sohn YW,Moon A

    更新日期：2007-07-08 00:00:00

  • Clinical management of third-generation EGFR inhibitor-resistant patients with advanced non-small cell lung cancer: Current status and future perspectives.

    abstract：:Discovery of activating mutations in epidermal growth factor receptor (EGFR) as a predictive biomarker for first-generation EGFR tyrosine kinase inhibitors (TKIs) has initiated an era of precision oncology for the treatment of advanced EGFR-mutant non-small cell lung cancer (NSCLC). Despite the robust efficacy of firs...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2019.05.044

    authors： Zhang YC,Zhou Q,Wu YL

    更新日期：2019-09-10 00:00:00

  • Steroid receptors in human lung cancer cytosols.

    abstract：:Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(82)90014-3

    authors： Chaudhuri PK,Thomas PA,Walker MJ,Briele HA,Das Gupta TK,Beattie CW

    更新日期：1982-09-01 00:00:00

  • Use of IL-2 gene transfer in local immunotherapy of cancer.

    abstract：:Insertion of functional interleukin-2 (IL-2) gene into a plasmacytoma cell line X63-Ag8.653 substantially reduced tumorigenicity of the resulting cloned cells, designated as X63-m-IL-2. Peritumoral administration of the X63-m-IL-2 cells, producing constitutively large quantities of IL-2, resulted in regressions of est...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(92)90104-4

    authors： Bubeník J,Lotzová E,Indrová M,Símová J,Jandlová T,Bubeníková D

    更新日期：1992-03-15 00:00:00

  • Therapeutic potential of targeted multifunctional nanocomplex co-delivery of siRNA and low-dose doxorubicin in breast cancer.

    abstract：:Malignant tumors remain a major health burden throughout the world, and effective therapeutic strategies are urgently needed. Combining gene therapy with chemotherapeutics in a single delivery system is more effective than co-treatment of cancer with individual delivery systems carrying either gene or drug. In this st...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.01.011

    authors： Dong D,Gao W,Liu Y,Qi XR

    更新日期：2015-04-10 00:00:00

  • Circulating RNA as a novel tumor marker: an in vitro study of the origins and characteristics of extracellular RNA.

    abstract：:Many clinical studies have shown that circulating RNA rises in cancer patients, but little is known about the origins of abnormally elevated extracellular RNA (exRNA). We designed four different culture conditions: serum-deprived, hypoxia, low temperature and exposure to an anticancer drug to investigate the origins i...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2007.09.016

    authors： Zhou H,Xu W,Qian H,Yin Q,Zhu W,Yan Y

    更新日期：2008-01-18 00:00:00

  • Lumican core protein inhibits melanoma cell migration via alterations of focal adhesion complexes.

    abstract：:Lumican is a small leucine-rich proteoglycan (SLRP) of the extracellular matrix (ECM) with anti-tumor activity. We recently demonstrated that lumican inhibits the migration of melanoma cells and identified beta1 integrin as mediator of this effect [M.F. D'Onofrio, S. Brézillon, T. Baranek, C. Perreau, P.J. Roughley, F...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2009.03.032

    authors： Brézillon S,Radwanska A,Zeltz C,Malkowski A,Ploton D,Bobichon H,Perreau C,Malicka-Blaszkiewicz M,Maquart FX,Wegrowski Y

    更新日期：2009-09-28 00:00:00

  • Clastogenic and cytotoxic effects of spermine oxidation products in mouse lymphoma L5178Y cells.

    abstract：:Treatment of mouse lymphoma L5178Y cells with spermine in Fischer's medium containing bovine serum lead to formation of chromatid aberrations. The cause of this effect seems to be that bovine serum contains spermine oxidase which catalyzes oxidation of spermine to unstable aldehyde derivatives (oxidized spermine) and ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(88)90044-4

    authors： Bouzyk E,Rosiek O

    更新日期：1988-02-01 00:00:00

  • Prognostic significance of microvessel density, vascular cuffing and vascular endothelial growth factor expression in ovarian carcinoma: a special review for clear cell adenocarcinoma.

    abstract：:Our purpose is to demonstrate the relationship between microvessel density (MVD), vascular cuffing (VC), vascular endothelial growth factor (VEGF) expression and clinicopathological parameters in ovarian cancer. Surgical specimens from 105 primary ovarian cancers were examined for vascularization and VEGF expression b...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(01)00754-6

    authors： Ogawa S,Kaku T,Kobayashi H,Hirakawa T,Ohishi Y,Kinukawa N,Nakano H

    更新日期：2002-02-08 00:00:00

  • Antitumor activity of nanoliposomes encapsulating the novobiocin analog 6BrCaQ in a triple-negative breast cancer model in mice.

    abstract：:In this study, we investigated the anticancer efficacy of pegylated liposomes containing 6BrCaQ, an hsp90 inhibitor derived from novobiocin. 6BrCaQ has been previously identified as the most potent compound in a series of quinoleic novobiocin analogs but is poorly water-soluble. We investigated, for the first time, th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2018.06.001

    authors： Sauvage F,Fattal E,Al-Shaer W,Denis S,Brotin E,Denoyelle C,Blanc-Fournier C,Toussaint B,Messaoudi S,Alami M,Barratt G,Vergnaud-Gauduchon J

    更新日期：2018-09-28 00:00:00

  • Polyamine levels in sarcoma-bearing rats in relation to growth and necrosis of the tumour cells.

    abstract：:Putrescine (PU), spermidine (SPD) and spermine (SPM) levels in blood serum of MC Sa 1828 P-bearing rats have been studied in relation to tumour weight and the histological picture. A statistically significant increase of PU and SPD was found in the course of tumour development. Decrease in the level of polyamines in t...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(87)90073-5

    authors： Kaminski K,Maslinski C,Stanosek J,Szczurek Z

    更新日期：1987-01-01 00:00:00

  • Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma.

    abstract：:Development of chemotherapy resistance remains a major obstacle for glioma management. Exosome-mediated transfer of circular RNAs (circRNAs) are being found to have relevance to many human cancers, including glioma. The purpose of this study is to explore the effect and underlying mechanism of exosomal circRNA nuclear...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.03.002

    authors： Ding C,Yi X,Wu X,Bu X,Wang D,Wu Z,Zhang G,Gu J,Kang D

    更新日期：2020-06-01 00:00:00

  • Targeting Hsp70: A possible therapy for cancer.

    abstract：:In all organisms, heat-shock proteins (HSPs) provide an ancient defense system. These proteins act as molecular chaperones by assisting proper folding and refolding of misfolded proteins and aid in the elimination of old and damaged cells. HSPs include Hsp100, Hsp90, Hsp70, Hsp40, and small HSPs. Through its substrate...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2016.01.056

    authors： Kumar S,Stokes J 3rd,Singh UP,Scissum Gunn K,Acharya A,Manne U,Mishra M

    更新日期：2016-04-28 00:00:00

  • Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer.

    abstract：:Tyrosine kinase inhibitor (TKI) treatment is the first-line therapy for non-small cell lung cancer (NSCLC) caused by activating mutations of epidermal growth factor receptor (EGFR). However, acquired resistance to EGFR-TKI occurs almost inevitably. Aberrant activation of proto-oncogene MET has been known to confer EGF...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2020.09.003

    authors： Quan C,Chen Y,Wang X,Yang D,Wang Q,Huang Y,Petersen RB,Liu X,Zheng L,Li Y,Huang K

    更新日期：2020-12-28 00:00:00

  • Human DNAJ in cancer and stem cells.

    abstract：:The heat shock protein 40kDa (HSP40/DNAJ) co-chaperones constitute the largest and most diverse sub-group of the heat shock protein (HSP) family. DNAJ are widely accepted as regulators of HSP70 function, but also have roles as co-chaperones for the HSP90 chaperone machine, and a growing number of biological functions ...

    journal_title：Cancer letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.canlet.2011.08.019

    authors： Sterrenberg JN,Blatch GL,Edkins AL

    更新日期：2011-12-22 00:00:00

  • Identification of epidermal growth factor receptor (EGFR) genetic variants that modify risk for head and neck squamous cell carcinoma.

    abstract：:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.12.008

    authors： Fung C,Zhou P,Joyce S,Trent K,Yuan JM,Grandis JR,Weissfeld JL,Romkes M,Weeks DE,Egloff AM

    更新日期：2015-02-28 00:00:00

  • Four types of fatty acids exert differential impact on pancreatic cancer growth.

    abstract：:Increased fatty acids (FAs) regulate pancreatic cancer progression, however, the detailed mechanism is not clear, and different forms of FAs may play diversified roles in pancreatic cancer. To elucidate the underlying mechanism, we compared the effects of four major types of FAs on pancreatic cancer growth both in cel...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2015.02.002

    authors： Yu M,Liu H,Duan Y,Zhang D,Li S,Wang F

    更新日期：2015-05-01 00:00:00

  • Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China.

    abstract：:We analyzed TP53 codon 72 polymorphism, HPV DNA in 32 subjects with oesophageal cancer and 57 healthy subjects with normal oesophageal cytology from an area of China with a high prevalence for this cancer (Linxian County, Henan Province). The frequency of the proline allele (0.63) was significantly higher in the Chine...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3835(00)00643-1

    authors： Peixoto Guimaraes D,Hsin Lu S,Snijders P,Wilmotte R,Herrero R,Lenoir G,Montesano R,Meijer CJ,Walboomers J,Hainaut P

    更新日期：2001-01-26 00:00:00

  • The expression and function of miRNA-451 in non-small cell lung cancer.

    abstract：:miRNAs are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional and translational levels. miRNA-451 was previously reported to be down-regulated in gastric and colorectal cancers. Here, we showed that miRNA-451 expression decreased in non-small cell lung cancer (NSCLC) tissues an...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2011.07.026

    authors： Wang XC,Tian LL,Jiang XY,Wang YY,Li DG,She Y,Chang JH,Meng AM

    更新日期：2011-12-08 00:00:00

  • Dose-response study of MeIQx carcinogenicity in F344 male rats.

    abstract：:The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimen...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(94)90295-x

    authors： Kushida H,Wakabayashi K,Sato H,Katami M,Kurosaka R,Nagao M

    更新日期：1994-08-15 00:00:00

  • Chromosomal end-to-end fusions in immortalized mouse embryonic fibroblasts deficient in the DNA-dependent protein kinase catalytic subunit.

    abstract：:Telomeres constitute the ends of the linear eukaryotic chromosomes and are essential for the maintenance of chromosome stability and genome integrity. One of the consequences of an altered telomere structure is the formation of telomeric fusions (TFs), that is aberrant chromosomes in which two elements are fused at th...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2003.08.028

    authors： Rebuzzini P,Lisa A,Giulotto E,Mondello C

    更新日期：2004-01-08 00:00:00

  • Mutagenicity of the two main components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium.

    abstract：:One of the 2 main components of the commercially available carcinogenic aristolochic acid (AA) was isolated, the other was enriched. Three different aristolochic acid samples (AAI 99% pure; AAI 65% + AAII 35%; AAI 32% + AAII 68%) were assayed for mutagenic activity in Salmonella typhimurium TA1537, TA100 and TA100 NR ...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/0304-3835(84)90067-3

    authors： Schmeiser HH,Pool BL,Wiessler M

    更新日期：1984-05-01 00:00:00

  • Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization.

    abstract：:Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...

    journal_title：Cancer letters

    pub_type： 杂志文章

    doi：10.1016/j.canlet.2014.07.048

    authors： Kim YH,Yoo KC,Cui YH,Uddin N,Lim EJ,Kim MJ,Nam SY,Kim IG,Suh Y,Lee SJ

    更新日期：2014-11-01 00:00:00