Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma.

abstract：:This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HR...

journal_title：Cancer letters

authors： Martin LM,Marples B,Lynch TH,Hollywood D,Marignol L

更新日期：2014-07-10 00:00:00

abstract：:Forty female CBA mice aged 3-4 months were exposed twice a week during 2 months to intravaginal applications of polyurethane sponges impregnated with 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in triethyleneglycol. Three hours after each application the sponges were taken out. Starting from the day of the ...

journal_title：Cancer letters

authors： Anisimov VN,Zabezhinski MA,Popovich IG,Zaripova EA,Musatov SA,Andre V,Vigreux C,Godard T,Sichel F

更新日期：2000-08-11 00:00:00

abstract：:The role of the gastrointestinal microflora in the nitrate-dependent formation of nitrosoproline was assessed in control and antibiotic-treated rats. Urinary nitrosoproline excretion as an index of in vivo nitrosamine formation was shown to be unaffected by bacterial decontamination of the alimentary tract, and procee...

journal_title：Cancer letters

authors： Mallett AK,Rowland IR,Cottrell RC,Gangolli SD

更新日期：1984-12-01 00:00:00

abstract：:Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...

journal_title：Cancer letters

authors： Kikuchi M,Katoh H,Waraya M,Tanaka Y,Ishii S,Tanaka T,Nishizawa N,Yokoi K,Minatani N,Ema A,Kosaka Y,Tanino H,Yamashita K,Watanabe M

更新日期：2017-01-01 00:00:00

abstract：:Previously, we have shown that dietary retinoic acid (RA) at pharmacological doses (30 micrograms/g of diet) inhibited the malignant conversion of skin papillomas to carcinomas induced by a two-stage carcinogenesis protocol with 7,12-dimethylbenz[a]anthracene as initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA)...

journal_title：Cancer letters

authors： Chen LC,Kirchhoff S,De Luca LM

更新日期：1994-04-01 00:00:00

abstract：:Exosomes are structurally and functionally pleiotropic nano-sized (~30-150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication and bio-waste disposal. To a great extent, exosomes represent biologi...

journal_title：Cancer letters

authors： Kumar A,Deep G

更新日期：2020-09-28 00:00:00

abstract：:The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the a...

journal_title：Cancer letters

authors： Chmurzyńska W,Manteuffel-Cymborowska M,Sikora E,Grzelakowska-Sztabert B

更新日期：1984-12-01 00:00:00

abstract：:We investigated the molecular mechanisms responsible for fisetin-induced apoptosis in U266 cells. Fisetin elicited the cytotoxicity in U266 cells, manifested as an increased fraction of the cells with sub-G1 content or stained positively with TUNEL labeling. Fisetin enhanced caspase-3 activation, downregulation of Bcl...

journal_title：Cancer letters

authors： Jang KY,Jeong SJ,Kim SH,Jung JH,Kim JH,Koh W,Chen CY,Kim SH

更新日期：2012-06-28 00:00:00

abstract：:CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val or CYP1A1*2B) polymorphisms were 0.25 and 0.33, respectively. Frequencies of variant alleles C (CYP...

journal_title：Cancer letters

authors： Quiñones L,Lucas D,Godoy J,Cáceres D,Berthou F,Varela N,Lee K,Acevedo C,Martínez L,Aguilera AM,Gil L

更新日期：2001-12-10 00:00:00

abstract：:HGT cells are a human gastric cell line derived from a tumour of the stomach. We have investigated the effects of lipoxygenase and cyclooxygenase metabolism inhibitors on HGT cell proliferation, on fatty acid composition of HGT cells and on the incorporation and distribution of arachidonic acid (AA) in HGT lipids. The...

journal_title：Cancer letters

authors： Denizot Y,Najid A,Rigaud M

更新日期：1993-09-15 00:00:00

abstract：:The involvement of beta-catenin gene alterations in pancreatic duct carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (BOP) in hamsters was examined by polymerase chain reaction-single strand conformation polymorphism analysis and the expression of beta-catenin protein was examined by immunohistochemistry. No m...

journal_title：Cancer letters

authors： Kubozoe T,Tsujiuchi T,Murata N,Sasaki Y,Tsunoda T,Konishi Y,Tsutsumi M

更新日期：2001-07-10 00:00:00

abstract：:This study highlights the systemic oxidative changes in patients submitted to primary cutaneous melanoma removal. Cutaneous melanoma is highly aggressive and its incidence is increasing worldwide. We evaluated systemic oxidative stress (OS) and 3-nitrotyrosine (3-NT) expression in melanoma tissue in relation to the Br...

journal_title：Cancer letters

authors： Bernardes SS,de Souza-Neto FP,Ramalho LN,Derossi DR,Guarnier FA,da Silva CF,Melo GP,Simão AN,Cecchini R,Cecchini AL

更新日期：2015-06-01 00:00:00

abstract：:The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...

journal_title：Cancer letters

authors： Mikol YB,Poirier LA

更新日期：1981-08-01 00:00:00

abstract：:Natural products play a pivotal role in medicine especially in the cancer arena. Many drugs that are currently used in cancer chemotherapy originated from or were inspired by nature. Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Prel...

journal_title：Cancer letters

authors： Qazzaz ME,Raja VJ,Lim KH,Kam TS,Lee JB,Gershkovich P,Bradshaw TD

更新日期：2016-01-28 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:Three sections of brain tissue from 2,657 female C57BL/6 mice were stained with hematoxylin and eosin and evaluated microscopically for proliferative lesions. Mice had been treated with either split-dose ionizing radiation (0, 3.0, 4.0 and 5.1 Gy), chronic lifetime 60 Hz circularly polarized magnetic field exposure (a...

journal_title：Cancer letters

authors： Kharazi AI,Babbitt JT,Hahn TJ

更新日期：1999-12-01 00:00:00

abstract：:CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...

journal_title：Cancer letters

authors： Kim S,Cho CY,Lee D,Song DG,Kim HJ,Jung JW,Kim JE,Park D,Lee H,Um H,Park J,Choi Y,Kim Y,Nam SH,Lee JW

更新日期：2018-12-01 00:00:00

abstract：:The effects of caloric restriction on the incidence of mammary tumor development, the levels of the expression of mouse mammary tumor virus (MMTV)- and prolactin-RNA, as well as the levels of serum prolactin, were investigated in virgin RIII/Sa mice, a strain known to display a high incidence of spontaneous mammary tu...

journal_title：Cancer letters

authors： Li HW,Zhao W,Sarkar NH

更新日期：1994-05-16 00:00:00

abstract：:Twenty-seven patients with malignant teratoma, 19 of which received radiation, are presented and the radiation response analyzed. Radiotherapy seems most effective in the palliation of undifferentiated (embryonal) teratoma of the gonads and sacrococcygeal region in early childhood. It is less effective, yet useful, in...

journal_title：Cancer letters

authors： Pantoja E,Roswit B

更新日期：1975-11-01 00:00:00

abstract：:Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiati...

journal_title：Cancer letters

authors： Ramírez MJ,Minguillón J,Loveless S,Lake K,Carrasco E,Stjepanovic N,Balmaña J,Català A,Mehta PA,Surrallés J

更新日期：2020-03-01 00:00:00

abstract：:Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has cancer chemopreventive activity. We investigated the effects of resveratrol on DNA binding via esterification reactions with 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP...

journal_title：Cancer letters

authors： Dubuisson JG,Dyess DL,Gaubatz JW

更新日期：2002-08-08 00:00:00

abstract：:This study tested the effect of intratumoral injection with activated tumor-infiltrating lymphocytes (TIL), and simultaneous administration of recombinant interleukin-2 (rIL-2) and interferon alpha (IFN-alpha) (LII protocol), on mouse liver tumor. Group I (n = 10) served as the controls. Group II (n = 17) received rIL...

journal_title：Cancer letters

authors： Liu DL,Håkansson CH,Seifert J

更新日期：1994-09-30 00:00:00

abstract：:An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, t...

journal_title：Cancer letters

authors： Glebova K,Veiko N,Kostyuk S,Izhevskaya V,Baranova A

更新日期：2015-01-01 00:00:00

abstract：:We investigated the influence of TNF-alpha on the metastasis of cancer cells. Treatment of cultured colon 26 cells with TNF-alpha enhanced metastatic properties including production of MMP-9, adhesion, migration and invasion. Cells treated with TNF-alpha in vitro showed marked potential to metastasize to the lung and ...

journal_title：Cancer letters

authors： Choo MK,Sakurai H,Koizumi K,Saiki I

更新日期：2005-12-08 00:00:00

abstract：:In a comparative experimental study, excisions of a transplanted Lewis lung carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional methods, namely common scalpel and diathermy. The results showed a significant reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%) af...

journal_title：Cancer letters

authors： Peled I,Shohat B,Gassner S,Kaplan I

更新日期：1976-09-01 00:00:00

abstract：:Two human cell lines, one established from a colon carcinoma (SW480) and the other from its lymph node metastasis (SW620), were compared with respect to their migration capacity employing a three-dimensional collagen matrix and time-lapse video recording. Non-motile cells were characterized by a round shape, whereas m...

journal_title：Cancer letters

authors： Kubens BS,Zänker KS

更新日期：1998-09-11 00:00:00

abstract：:Recent work has demonstrated that oncogenes and tumor suppressor proteins regulate apoptotic cell death. Current efforts are therefore directed at determining how they exert their effects. It appears that oncogenes can control activation of the apoptosis endonuclease(s) either by regulating the signal(s) that trigger ...

journal_title：Cancer letters

authors： McConkey DJ,Fernandez A,Trent J 2nd,Ananthaswamy HN

更新日期：1995-07-20 00:00:00

abstract：:Carcinogenicity of quercetin and rutin were examined in inbred ACI strain rats. Rats were given a diet containing 1% or 5% quercetin or 5% rutin for 540 days, or 10% quercetin and 10% rutin for 850 days. Rats in control groups were fed a normal basal diet. Most tumors found in experimental groups were also found in th...

journal_title：Cancer letters

authors： Hirono I,Ueno I,Hosaka S,Takanashi H,Matsushima T,Sugimura T,Natori S

更新日期：1981-06-01 00:00:00

abstract：:We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%)...

journal_title：Cancer letters

authors： Iolascon A,Lo Cunsolo C,Giordani L,Cusano R,Mazzocco K,Boumgartner M,Ghisellini P,Faienza MF,Boni L,De Bernardi B,Conte M,Romeo G,Tonini GP

更新日期：1998-08-14 00:00:00

abstract：:A derivative of coumarin, 8-nitro-7-hydroxycoumarin (8-NO2-7-OHC), was synthesised, purified and characterised. The cytostatic and cytotoxic nature of this compound was determined using both human and animal cell lines grown in vitro for 96 h in the presence of drug (0-500 microM, equivalent to 0-104 microg/ml). 8-NO2...

journal_title：Cancer letters

authors： Egan D,James P,Cooke D,O'Kennedy R

更新日期：1997-10-14 00:00:00