Abstract:
:This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Martin LM,Marples B,Lynch TH,Hollywood D,Marignol Ldoi
10.1016/j.canlet.2013.12.015subject
Has Abstractpub_date
2014-07-10 00:00:00pages
98-106issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(13)00840-9journal_volume
349pub_type
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