Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells.

abstract：:Gemcitabine is the cornerstone of pancreatic cancer treatment. Although effective in most patients, development of tumor resistance to gemcitabine can critically limit its efficacy. The mechanisms responsible for this phenomenon remain elusive, but evidence suggests that ubiquitin-specific peptidases (USPs) may be key...

journal_title：Cancer letters

authors： Ma T,Chen W,Zhi X,Liu H,Zhou Y,Chen BW,Hu L,Shen J,Zheng X,Zhang S,Zhang B,Li H,Liang T

更新日期：2018-11-01 00:00:00

abstract：:Ring1 and YY1 binding protein (RYBP) is a member of the Polycomb group (PcG) proteins and regulates cell growth through both PcG-dependent and -independent mechanisms. Our initial study indicated that RYBP is down-regulated in human non-small cell lung cancer (NSCLC) tissues. The present study determined the molecular...

journal_title：Cancer letters

authors： Voruganti S,Xu F,Qin JJ,Guo Y,Sarkar S,Gao M,Zheng Z,Wang MH,Zhou J,Qian B,Zhang R,Wang W

更新日期：2015-12-28 00:00:00

abstract：:Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured c...

journal_title：Cancer letters

authors： Rho SB,Byun HJ,Park SY,Chun T

更新日期：2008-11-28 00:00:00

abstract：:The 825C>T polymorphism in the gene for the G-protein beta3 subunit (GNB3) has been linked to the occurrence of a splice variant of GNB3 and distinct cellular and metabolic features and may be associated with malignant disease. 500 patients with histologically confirmed breast cancer and 500 female age-matched healthy...

journal_title：Cancer letters

authors： Krippl P,Langsenlehner U,Renner W,Yazdani-Biuki B,Wolf G,Wascher TC,Paulweber B,Samonigg H

更新日期：2004-03-31 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

journal_title：Cancer letters

authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

更新日期：2016-12-01 00:00:00

abstract：:Mutations in oncogenes and tumor suppressor genes confer a fitness advantage to cells that can lead to cancer. The tumor phenotype normally results from the interaction of many mutant genes making it difficult to estimate the fitness advantage provided by any oncogene, except when tumors depend on one oncogene only. W...

journal_title：Cancer letters

authors： Traulsen A,Pacheco JM,Dingli D

更新日期：2010-08-01 00:00:00

abstract：:The important goal of cancer drug discovery is to develop therapeutic agents that are effective, safe, and affordable. In the present study, we demonstrated that alantolactone, which is a sesquiterpene lactone, has potential activity against triple-negative breast cancer MDA-MB-231 cells by suppressing the signal tran...

journal_title：Cancer letters

authors： Chun J,Li RJ,Cheng MS,Kim YS

更新日期：2015-02-01 00:00:00

abstract：:Thyroid hormone receptor interactor 4 (TRIP4), a subunit of the tetrameric nuclear activating signal co-integrator 1 (ASC-1) complex, exerts pro-tumorigenic effects. The role for TRIP4 in the regulation of cervical cancer growth and radiation resistance is presently unknown. In this study, TRIP4 was found to be highly...

journal_title：Cancer letters

authors： Che Y,Li Y,Zheng F,Zou K,Li Z,Chen M,Hu S,Tian C,Yu W,Guo W,Luo M,Deng W,Zou L

更新日期：2019-06-28 00:00:00

abstract：:Tumor-associated macrophages (TAMs) have important roles in the angiogenesis and tumor immunosuppression of various cancers, including esophageal squamous cell carcinomas (ESCCs). To elucidate the roles of TAMs in ESCCs, we compared the gene expression profiles between human peripheral blood monocyte-derived macrophag...

journal_title：Cancer letters

authors： Takase N,Koma Y,Urakawa N,Nishio M,Arai N,Akiyama H,Shigeoka M,Kakeji Y,Yokozaki H

更新日期：2016-09-28 00:00:00

abstract：:The comparative effects of the subchronic administration to rats of ethionine-supplemented and of chemically defined methyl-deficient diets on the hepatic levels of S-adenosylmethionine (SAM) and of ornithine decarboxylase (ODC), an enzyme marker of cell proliferation, were studied. Both treatments led to decreased he...

journal_title：Cancer letters

authors： Mikol YB,Poirier LA

更新日期：1981-08-01 00:00:00

abstract：:N-[2-(p-bromocinnamylmethylamino) ethyl]-5-isoquinolinesulfonamide (H-87), a newly synthesized inhibitor of protein kinase A, significantly decreased the drug resistance of multidrug resistant human U937/M cells, mouse FM3A/M and P388/M cells. Northern blot analysis showed MDR1 gene expression was decreased in H-87-tr...

journal_title：Cancer letters

authors： Kim SH,Park JI,Chung BS,Kang CD,Hidaka H

更新日期：1993-10-15 00:00:00

abstract：:Natural products play a pivotal role in medicine especially in the cancer arena. Many drugs that are currently used in cancer chemotherapy originated from or were inspired by nature. Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Prel...

journal_title：Cancer letters

authors： Qazzaz ME,Raja VJ,Lim KH,Kam TS,Lee JB,Gershkovich P,Bradshaw TD

更新日期：2016-01-28 00:00:00

abstract：:One of the 2 main components of the commercially available carcinogenic aristolochic acid (AA) was isolated, the other was enriched. Three different aristolochic acid samples (AAI 99% pure; AAI 65% + AAII 35%; AAI 32% + AAII 68%) were assayed for mutagenic activity in Salmonella typhimurium TA1537, TA100 and TA100 NR ...

journal_title：Cancer letters

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1984-05-01 00:00:00

abstract：:Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...

journal_title：Cancer letters

authors： Baxt WG

更新日期：1994-03-15 00:00:00

abstract：:Liver hyperplasia was induced in rats by daily administration of methylclofenapate (25 mg/kg by gavage). An increase in the incidence of colchicine-arrested metaphases was observed with peaks occurring at 40 h (1.3%), 64 h (6.4%) and 84 h (6.8%) after the start of treatment. This response contrasted with the much larg...

journal_title：Cancer letters

authors： Bybee A,Styles JA,Beck SL,Blackburn D

更新日期：1990-07-16 00:00:00

abstract：:Prostate cancer is a major health concern and is treated based on its hormone dependence. Agents that alter hormone action can have substantial biological effects on prostate cancer development and progression. As such, there is significant interest in uncovering the potential effects of endocrine disrupting compound ...

journal_title：Cancer letters

authors： Hess-Wilson JK,Knudsen KE

更新日期：2006-09-08 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, which ranks as the sixth of cancer-related death. Despite the emergence of targeted therapy, advanced-stage HCC remains largely incurable due to low response rate and therapeutic resistance. In this review, we mainly focused on the current pro...

journal_title：Cancer letters

authors： Chen S,Cao Q,Wen W,Wang H

更新日期：2019-09-28 00:00:00

abstract：:The oral administration of a single 20mg dose of 7,12-dimethylbenz[a]anthracene regularly and rapidly induces mammary cancer in 50 day-old Sprague-Dawley female rats [Experimental Leukemia and Mammary Cancer, 1979, p. 74]. Several mechanisms by which 7,12-dimethylbenz[a]anthracene induces mammary cancer have been prop...

journal_title：Cancer letters

authors： Horn J,Lehner AF,Flesher JW

更新日期：2005-04-08 00:00:00

abstract：:The notions of inter- and intra-tumour heterogeneity (ITH) have been recognised for many years but recent advances in sequencing technology are allowing the true extent of both forms of heterogeneity to be revealed in detail for the first time. In this review we examine the current evidence for ITH, the possibility of...

journal_title：Cancer letters

authors： Horswell S,Matthews N,Swanton C

更新日期：2013-11-01 00:00:00

abstract：:The aim of the study was to demonstrate the role of parathyroid hormone related protein (PTHrP) in stimulating aldo-keto reductase (AKR) 1C3 expression in prostate cancer (CaP) cells. CaP cell proliferation and resistance to apoptosis was increased by PTHrP transfection. Conversely, reducing AKR1C3 expression by siRNA...

journal_title：Cancer letters

authors： Downs TM,Burton DW,Araiza FL,Hastings RH,Deftos LJ

更新日期：2011-07-01 00:00:00

abstract：:The B16 malignant melanoma and its F1 variant line were described and compared in syngeneic C57BL/6 mice at short and long term periods after transplantation. No observable differences in gross or histological features were noted. In both lines, liver and lung metastasis was confirmed and kidney colonization proposed....

journal_title：Cancer letters

authors： Wosko TJ,Ferrara DT,Sartori LS

更新日期：1984-08-01 00:00:00

abstract：:The growth of a transplantable myeloid leukaemia into its syngeneic host is accompanied by a progressive increase in the number of blood monocytes. These were shown to be of host origin and were not derived from the inoculated leukaemia cells. The host response which is responsible for the monocytosis differs from tha...

journal_title：Cancer letters

authors： Gauci CL,Wrathmell A,Alexander P

更新日期：1975-09-01 00:00:00

abstract：:This study identified LIMK2 kinase as a disease-specific target in castration resistant prostate cancer (CRPC) pathogenesis, which is upregulated in response to androgen deprivation therapy, the current standard of treatment for prostate cancer. Surgical castration increases LIMK2 expression in mouse prostates due to ...

journal_title：Cancer letters

authors： Nikhil K,Chang L,Viccaro K,Jacobsen M,McGuire C,Satapathy SR,Tandiary M,Broman MM,Cresswell G,He YJ,Sandusky GE,Ratliff TL,Chowdhury D,Shah K

更新日期：2019-04-28 00:00:00

abstract：:Treatment of human epidermoid carcinoma A431 cells with transplatin (trans-DDP) and beta-hydroxyisovalerylshikon (beta-HIVS) together had a strong inhibitory effect on A431 cells. By contrast, trans-DDP and beta-HIVS by themselves, at the same respective concentrations, had practically no effect. The tyrosine kinase a...

journal_title：Cancer letters

authors： Xu Y,Nakajo S,Nakaya K

更新日期：2002-12-15 00:00:00

abstract：:The effect of different tannin-containing aqueous solutions on the carcinogenic action of benzo(a)pyrene (BP) on the mouse skin was investigated. It was found that the appearance of tumours was accelerated in mice treated with either tea or an oak extract after a single application of BP. The time of appearance of tum...

journal_title：Cancer letters

authors： Bogovski P,Day N

更新日期：1977-07-01 00:00:00

abstract：:The pyrimido-pyrimidine derivative RA233 was found to selectively kill cultured mouse B16 melanoma cells after prolonged hypoxia. At the optimum cytotoxic concentration (100 microM), RA233 reduced cell clonogenicity by about 80% when administered during long-term hypoxia of 4 days. Comparable cytotoxicity was also evi...

journal_title：Cancer letters

authors： Stackpole CW,Omar RA,Fornabaio DM,Kim YS

更新日期：1988-09-01 00:00:00

abstract：:Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and prolifer...

journal_title：Cancer letters

authors： Zhang Z,Cao L,Li J,Liang X,Liu Y,Liu H,Du J,Qu Z,Cui M,Liu S,Gao L,Ma C,Zhang L,Han L,Sun W

更新日期：2008-08-18 00:00:00

abstract：:Inactivation of antineoplastics is a serious problem in cancer therapy, and prevention of the inactivation is a surpassing strategy for enhancement of their therapeutic effects. BOF-A2, which contains both EM-FU, a masked form of 5-fluorouracil (5-FU), and CNDP, an inhibitor of 5-FU degradation, was developed with thi...

journal_title：Cancer letters

authors： Yoneda K,Yamamoto T,Ueta E,Osaki T

更新日期：1999-03-22 00:00:00

abstract：:2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine (NPEOC-DAC), decitabine with a modification of the N4 position of the azacitidine ring can be used to inhibit DNA methyltransferase. This modification protects the azacitidine ring and can be cleaved by carboxylesterase to release decitabine. NPEOC-DAC was 23...

journal_title：Cancer letters

authors： Byun HM,Choi SH,Laird PW,Trinh B,Siddiqui MA,Marquez VE,Yang AS

更新日期：2008-08-08 00:00:00

abstract：:The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able ...

journal_title：Cancer letters

authors： Ratikan JA,Micewicz ED,Xie MW,Schaue D

更新日期：2015-11-28 00:00:00