Reduction in NaCl-enhanced gastric carcinogenesis in rats fed a high-protein diet.

abstract：:In experimental cancer chemoprevention studies, the doses of the agent used to produce an inhibitory response are generally very high, sometimes bordering on levels that will result in toxicity to the test animals. The present study was designed to test the hypothesis that low doses of two or more agents may be just a...

journal_title：Cancer letters

authors： Ip C

更新日期：1988-04-01 00:00:00

abstract：:The transcription factor NPAS2 is one of nine human core circadian genes that influence a variety of biological processes by regulating the 24-h circadian rhythm. Recently, it has been shown that NPAS2 is a risk biomarker in human cancers and plays a role in tumorigenesis by affecting cancer-related gene expression, a...

journal_title：Cancer letters

authors： Yi CH,Zheng T,Leaderer D,Hoffman A,Zhu Y

更新日期：2009-11-01 00:00:00

abstract：:Previously, we have shown that simian virus 40 (SV40) T antigen can directly cause apoptosis in immortalized human epithelial cells under normal growth conditions. In this study, we further characterized the mechanism of T-antigen-mediated apoptosis involving p53 and whether T antigen can suppress erbB2/neu gene expre...

journal_title：Cancer letters

authors： Wang CH,Chen YL,Tsao YP,Chen SL

更新日期：1999-03-22 00:00:00

abstract：:As myeloma cells actively produce and secrete immunoglobulins, they are prone to ER stress, which if unresolved leads to apoptosis. We found that myeloma cell death induced by the ER stressor Thapsigargin was highly variable, ranging from 2 to 89%. Induction of ATF4 and CHOP was observed in myeloma cells under Thapsig...

journal_title：Cancer letters

authors： Gomez-Bougie P,Halliez M,Moreau P,Pellat-Deceunynck C,Amiot M

更新日期：2016-12-28 00:00:00

abstract：:While the vast majority of cancers are believed to occur sporadically, most forms of cancer, both adult and paediatric, have a hereditary equivalent. In the case of adult malignancies, these include hereditary breast and ovarian cancer and syndromes such as the multiple endocrine neoplasias types 1 and 2 characterised...

journal_title：Cancer letters

authors： Marsh D,Zori R

更新日期：2002-07-26 00:00:00

abstract：:Ellagic acid (EA) and 13-cis-retinoic acid (CRA), both alone and in combination, were tested for their ability to inhibit N-nitrosobenzylmethylamine-induced tumors in the rat esophagus. Groups of male rats were fed AIN-76A diet containing EA (4 g/kg), CRA (240 mg/kg), or a combination of EA and CRA (4 g/kg and 240 mg/...

journal_title：Cancer letters

authors： Daniel EM,Stoner GD

更新日期：1991-02-01 00:00:00

abstract：:Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg ...

journal_title：Cancer letters

authors： Mitsumori K,Yasuhara K,Mori I,Hayashi S,Shimo T,Onodera H,Nomura T,Hayashi Y

更新日期：1998-07-17 00:00:00

abstract：:Two human prostate tumor cell lines which exhibit a 2.4-fold difference in sensitivity to cis-platinum (cis-Pt) were found to possess slightly different sulphydryl contents, and the presence of a metallothionein-like zinc-binding protein was demonstrated in the line exhibiting relative resistance to cis-Pt. Although t...

journal_title：Cancer letters

authors： Metcalfe SA,Cain K,Hill BT

更新日期：1986-05-01 00:00:00

abstract：:To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal an...

journal_title：Cancer letters

authors： Okuda T,Wakasa K,Kubo S,Hamada T,Fujita M,Enomoto T,Haba T,Hirohashi K,Kinoshita H

更新日期：2001-03-10 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) following androgen deprivation therapy remains a major obstacle advanced prostate cancer management. Aromatase catalyzes estrogen from androgens, yet the role of aromatase-generated endogenous estrogen in CRPC is poorly understood. In this study, we assessed the expression a...

journal_title：Cancer letters

authors： Liang Z,Cao J,Tian L,Shen Y,Yang X,Lin Q,Zhang R,Liu H,Du X,Shi J,Zhang J

更新日期：2019-12-28 00:00:00

abstract：:This study highlights the systemic oxidative changes in patients submitted to primary cutaneous melanoma removal. Cutaneous melanoma is highly aggressive and its incidence is increasing worldwide. We evaluated systemic oxidative stress (OS) and 3-nitrotyrosine (3-NT) expression in melanoma tissue in relation to the Br...

journal_title：Cancer letters

authors： Bernardes SS,de Souza-Neto FP,Ramalho LN,Derossi DR,Guarnier FA,da Silva CF,Melo GP,Simão AN,Cecchini R,Cecchini AL

更新日期：2015-06-01 00:00:00

abstract：:The AT-rich interaction domain 1A (ARID1A, also known as BAF250a) is a chromatin remodeling gene, which frequently mutates across a broad spectrum of cancers with loss expression of the ARID1A protein. Recently, the association between ARID1A deficiency and immune checkpoint blockade (ICB) therapy has been reported. A...

journal_title：Cancer letters

authors： Hu G,Tu W,Yang L,Peng G,Yang L

更新日期：2020-03-31 00:00:00

abstract：:To clarify the detailed molecular mechanism underlying cellular responses to nonthermal low-intensity pulsed ultrasound (LIPUS), gene expression patterns and genetic networks in human lymphoma U937 cells were examined using global-scale microarrays and computational gene expression analysis tools. Six hours after LIPU...

journal_title：Cancer letters

authors： Tabuchi Y,Takasaki I,Zhao QL,Wada S,Hori T,Feril LB Jr,Tachibana K,Nomura T,Kondo T

更新日期：2008-11-08 00:00:00

abstract：:Spontaneous testicular teratomas which develop at a high rate in 129/Sv-Sl/+ mice are thought to be derived from germ cells. The teratomas present initially as groups of atypical germ-like cells within seminiferous cords of the 15.5 days post coitum (dpc) embryonic testes. These pluripotent teratoma stem cells are cap...

journal_title：Cancer letters

authors： Wang D,Enders GC

更新日期：1996-02-27 00:00:00

abstract：:Paclitaxel (Taxol) is currently used as the front-line chemotherapeutic drug for many types of human cancers. However, the emergence of drug resistance has been a major obstacle to the effective treatment of cancers in clinical settings. The transcription factor Forkhead box protein C2 (FOXC2) was recently demonstrate...

journal_title：Cancer letters

authors： Zhou Z,Zhang L,Xie B,Wang X,Yang X,Ding N,Zhang J,Liu Q,Tan G,Feng D,Sun LQ

更新日期：2015-07-28 00:00:00

abstract：:Triple negative breast cancer (TNBC) typically exhibits rapid progression, high mortality and faster relapse rates relative to other breast cancer subtypes. In this report we examine the combination of taxanes (paclitaxel or docetaxel) with a breast cancer stem cell (CSC)-targeting agent sulforaphane for use against T...

journal_title：Cancer letters

authors： Burnett JP,Lim G,Li Y,Shah RB,Lim R,Paholak HJ,McDermott SP,Sun L,Tsume Y,Bai S,Wicha MS,Sun D,Zhang T

更新日期：2017-05-28 00:00:00

abstract：:5-fluorouracil (5-FU) is widely used in chemotherapy for colorectal cancer (CRC), but a high rate of chemoresistance reduces its effectiveness in clinical treatment. We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-...

journal_title：Cancer letters

authors： Liu C,Zhao Y,Wang J,Yang Y,Zhang Y,Qu X,Peng S,Yao Z,Zhao S,He B,Mi Q,Zhu Y,Liu X,Zou J,Zhang X,Du Q

更新日期：2020-02-01 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP), which hydrolyzes type I collagen and activates MMP-2, are deeply involved in angiogenesis as well as in tumor cell invasion and metastasis. We previously screened a number of natural and synthetic compounds to obtain a specific inhibitor of MT1-MMP and observed that ...

journal_title：Cancer letters

authors： Yamakawa S,Asai T,Uchida T,Matsukawa M,Akizawa T,Oku N

更新日期：2004-07-08 00:00:00

abstract：:The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able ...

journal_title：Cancer letters

authors： Ratikan JA,Micewicz ED,Xie MW,Schaue D

更新日期：2015-11-28 00:00:00

abstract：:The effect of diethylstilbestrol propionate (DES; 1 mg/kg body wt. was studied in the female offspring of rats exposed subcutaneously on the 19th day of gestation. Examination of vaginal smears showed persistent estrus in adult rats treated prenatally with DES. Compensatory ovarian hypertrophy (COH) induced by hemicas...

journal_title：Cancer letters

authors： Napalkov NP,Anisimov VN

更新日期：1979-02-01 00:00:00

abstract：:Continuous ethinyl estradiol treatment following ovariectomy at day 38 of BALB/cfC3H mice treated neonatally with estradiol resulted in a more organized vaginal epithelium than that seen in the absence of postnatal estrogen, 30 days after treatment was initiated. Although the epithelium became increasingly disorganize...

journal_title：Cancer letters

authors： Wong LM,Bern HA,Jones LA,Mills KT

更新日期：1982-11-01 00:00:00

abstract：:Treatment of glioblastoma remains a challenge in neuro-oncology. We investigated if treatment with neural stem cells engineered to express membrane-bound TRAIL (NSCs-mTRAIL) alone or in combination with proteasome inhibitors is a feasible therapeutic approach for experimental glioma. Glioma cells showed resistance to ...

journal_title：Cancer letters

authors： Balyasnikova IV,Ferguson SD,Han Y,Liu F,Lesniak MS

更新日期：2011-11-28 00:00:00

abstract：:BEC, a standard mixture of solasodine glycosides is effective in vivo against murine sarcoma 180 (S180), whereas the aglycone solasodine at equimolar concentrations is ineffective. The efficacy of BEC against S180 in vivo can be inhibited by rhamnose. Mice which are in their terminal stage with S180 can tolerate and b...

journal_title：Cancer letters

authors： Cham BE,Daunter B

更新日期：1990-12-17 00:00:00

abstract：:Carcinogenic and modification potential of 6-mercaptopurine (6-MP) was studied in a medium-term bioassay system for rat liver carcinogenesis. F344 male rats were initiated with a single dose (200 mg/kg body wt.) of diethylnitrosamine (DEN) i.p. and fed diets containing either 0.005% or 0.02% 6-MP with or without 0.05%...

journal_title：Cancer letters

authors： Amanuma T,Maruyama H,Tsujiuchi T,Tsutsumi M,Denda A,Konishi Y

更新日期：1992-06-15 00:00:00

abstract：:EGFR polymorphisms have not been thoroughly evaluated for association with head and neck squamous cell carcinoma (HNSCC) risk. We genotyped 578 HNSCC patients and 588 cancer-free controls for 60 EGFR single nucleotide polymorphisms (SNPs) and tested associations with HNSCC risk. EGFR intronic SNPs rs12535536, rs207511...

journal_title：Cancer letters

authors： Fung C,Zhou P,Joyce S,Trent K,Yuan JM,Grandis JR,Weissfeld JL,Romkes M,Weeks DE,Egloff AM

更新日期：2015-02-28 00:00:00

abstract：:We have characterized the changes in composition of the nuclear matrix-intermediate filament complex (NM-IF) isolated from prostate cancer (PCa), compared with benign prostatic hyperplasia (BPH). We prepared the NM-IF from ten patients undergoing radical retropubic prostectomy; the benign hyperplastic tissue was obtai...

journal_title：Cancer letters

authors： Alberti I,Parodi S,Barboro P,Sanna P,Nicolò G,Allera C,Patrone E,Galli S,Balbi C

更新日期：1996-12-03 00:00:00

abstract：:Recent studies in several tumor models indicated that treatment with angiogenic inhibitors may trigger induction of metastasis to other organs. Here we investigated modes of resistance and invasion in several tumor cell lines including 4T1 (breast), H460 (lung) and Colo205 (colorectal) using sunitinib at doses compara...

journal_title：Cancer letters

authors： Shojaei F,Simmons BH,Lee JH,Lappin PB,Christensen JG

更新日期：2012-07-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...

journal_title：Cancer letters

authors： Zhou R,Wu Y,Wang W,Su W,Liu Y,Wang Y,Fan C,Li X,Li G,Li Y,Xiong W,Zeng Z

更新日期：2018-07-01 00:00:00

abstract：:Emerging evidence indicates that cancer stem cells (CSCs) are involved in tumorigenesis, tumor recurrence, and therapeutic resistance in hepatocellular carcinoma (HCC). However, the mechanisms underlying HCC CSC regulation remain largely unknown. Here we report our analysis of 97 paraffin-embedded HCC tumor specimens....

journal_title：Cancer letters

authors： Fan Z,Duan J,Wang L,Xiao S,Li L,Yan X,Yao W,Wu L,Zhang S,Zhang Y,Li Y,Zhu X,Hu Y,Zhang D,Jiao S,Xu X

更新日期：2019-05-28 00:00:00

abstract：:Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal tr...

journal_title：Cancer letters

authors： Hermonat PL

更新日期：1994-06-30 00:00:00