Exosomes in hypoxia-induced remodeling of the tumor microenvironment.

abstract：:Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of...

journal_title：Cancer letters

authors： Braginskaja OV,Lazarev VV,Polsachev VI,Rubin LB,Stoskii VE

更新日期：1993-04-30 00:00:00

abstract：:To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...

journal_title：Cancer letters

authors： Chou YH,Chung KC,Jeng LB,Chen TC,Liaw YF

更新日期：1998-01-16 00:00:00

abstract：:Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, has been used for the treatment of several abnormal human conditions without apparent toxicity. Recent studies have revealed that CHL has the excellent chemopreventive potential. In the present investigation, we have found the inhibitory activities of CHL...

journal_title：Cancer letters

authors： Chung WY,Lee JM,Park MY,Yook JI,Kim J,Chung AS,Surh YJ,Park KK

更新日期：1999-10-18 00:00:00

abstract：:Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...

journal_title：Cancer letters

authors： Wu Q,Yang Z,Nie Y,Shi Y,Fan D

更新日期：2014-06-01 00:00:00

abstract：:Resveratrol is a plant polyphenol found in grapes and red wine. It has been found to have beneficial effects on the cardiovascular system. Resveratrol also inhibits the growth of various tumor cell lines in vitro and inhibits carcinogenesis in vivo. In this study we examined the effect of resveratrol on growth of two ...

journal_title：Cancer letters

authors： Niles RM,McFarland M,Weimer MB,Redkar A,Fu YM,Meadows GG

更新日期：2003-02-20 00:00:00

abstract：:Epigenetic silencing of HOPX has been shown to be frequent and specific in human cancers. HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation. In non-hereditary breast cancer, since roles of epigenetic modifications are more critical than in other cancers, t...

journal_title：Cancer letters

authors： Kikuchi M,Katoh H,Waraya M,Tanaka Y,Ishii S,Tanaka T,Nishizawa N,Yokoi K,Minatani N,Ema A,Kosaka Y,Tanino H,Yamashita K,Watanabe M

更新日期：2017-01-01 00:00:00

abstract：:We have examined the effect of theanine, a specific amino acid in green tea, on idarubicin (IDA)-induced antitumor activity and toxicity. In combination with theanine, IDA (0.25 mg/kg per day x4 days, a dose that does not show antitumor activity) had significant antitumor activity in P388-bearing mice. The IDA concent...

journal_title：Cancer letters

authors： Sadzuka Y,Sugiyama T,Sonobe T

更新日期：2000-10-01 00:00:00

abstract：:We have previously demonstrated that O-phospho-L-tyrosine (P-Tyr), a substrate for a wide range of PTPases, inhibits the growth of human renal cell carcinoma and human breast cancer cell lines and suppresses EGF-mediated EGFR tyrosine phosphorylation. We now show that P-Tyr inhibited the growth of the human hepatoma c...

journal_title：Cancer letters

authors： Mishra S,Hamburger AW

更新日期：1996-04-19 00:00:00

abstract：:In order to study the interaction between cis-diamminedichloroplatinum(II) (CDDP) and representative human DNA in a highly defined manner, alphoid sequence DNA was isolated from two human parental cancer lines (one of head and neck squamous cell origin, SCC-25, and one of breast carcinoma origin, MCF-7) as well as fro...

journal_title：Cancer letters

authors： Chan V,Elliott KE,Herman TS,Teicher BA

更新日期：1988-12-15 00:00:00

abstract：:The modulating effect of ethanol/acetone (E/A) soluble fractions, prepared from methanolic extracts of processed and unprocessed rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) as well as green (Camellia sinensis) teas was established in a two-stage mouse skin carcinogenesis assay. Topical applicatio...

journal_title：Cancer letters

authors： Marnewick J,Joubert E,Joseph S,Swanevelder S,Swart P,Gelderblom W

更新日期：2005-06-28 00:00:00

abstract：:The mutational activation of the neu proto-oncogene was analyzed in schwannomas of the peripheral nervous system transplacentally induced by N-ethyl-N-nitrosourea (ENU) in rats. All nine primary schwannomas investigated contained a T-->A transversion mutation at nucleotide 2012 of the neu gene, leading to the substitu...

journal_title：Cancer letters

authors： Ohgaki H,Vogeley KT,Kleihues P,Wechsler W

更新日期：1993-06-15 00:00:00

abstract：:Orlistat is an anti-obesity agent that increases the fecal fat excretion, which promotes colon carcinogenesis. Therefore, the present study was designed to verify the effects of Orlistat on the formation of rat colonic aberrant crypt foci (ACF) and cell proliferation evaluated by the PCNA method. Male Wistar rats rece...

journal_title：Cancer letters

authors： Garcia SB,Barros LT,Turatti A,Martinello F,Modiano P,Ribeiro-Silva A,Vespúcio MV,Uyemura SA

更新日期：2006-08-28 00:00:00

abstract：:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In ...

journal_title：Cancer letters

authors： Jackson KM,DeLeon M,Verret CR,Harris WB

更新日期：2002-04-25 00:00:00

abstract：:The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation t...

journal_title：Cancer letters

authors： Santana MA,Chasserot-Bolaz S,Beck B,Pogson CI

更新日期：1985-07-01 00:00:00

abstract：:To examine the role of diabetes in pancreatic cancer, 4 groups of Chinese hamsters--2 from genetically diabetic and 2 from non-diabetic lines--were treated with N-nitrosobis(2-oxo-propyl)amine (BOP) at different dose levels and intervals. In one group (referred to as the VA group), BOP was given weekly at a 5 mg/kg bo...

journal_title：Cancer letters

authors： Bell RH Jr,Pour PM

更新日期：1987-02-01 00:00:00

abstract：:Bone metastasis is a major cause of prostate cancer (PCa) mortality. Although docetaxel chemotherapy initially extends patients' survival, in most cases PCa becomes chemoresistant and eventually progresses without a cure. In this study, we developed a novel small-molecule compound BKM1972, which exhibited potent in vi...

journal_title：Cancer letters

authors： Chen Y,Gera L,Zhang S,Li X,Yang Y,Mamouni K,Wu AY,Liu H,Kucuk O,Wu D

更新日期：2019-04-01 00:00:00

abstract：:Pancreatic cancer is a highly lethal disease for which limited therapeutic options are available. Pancreatic cancer exhibits a pronounced collagen-rich stromal reaction, which induces chemoresistance by inhibiting drug diffusion into the tumor. Complementary treatment with oncolytic virus such as an oncolytic adenovir...

journal_title：Cancer letters

authors： Jung KH,Choi IK,Lee HS,Yan HH,Son MK,Ahn HM,Hong J,Yun CO,Hong SS

更新日期：2017-06-28 00:00:00

abstract：:YTH domain containing 2 (YTHDC2) is a member of the DExD/H-box family of ATP-dependent RNA helicases. We previously found that YTHDC2 expression is up-regulated in several human cancer cells. In this study, we demonstrate novel roles for YTHDC2 in metastasis of colon tumor cells via translation-dependent pathway. Knoc...

journal_title：Cancer letters

authors： Tanabe A,Tanikawa K,Tsunetomi M,Takai K,Ikeda H,Konno J,Torigoe T,Maeda H,Kutomi G,Okita K,Mori M,Sahara H

更新日期：2016-06-28 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known ab...

journal_title：Cancer letters

authors： Sun J,Luo Q,Liu L,Song G

更新日期：2018-07-28 00:00:00

abstract：:HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervent...

journal_title：Cancer letters

authors： Patil A,Sherbet GV

更新日期：2015-03-28 00:00:00

abstract：:Neuroblastoma (NB) is a solid childhood tumour that exhibits heterogeneous biological and clinical phenotypes. Multiple drug resistance marks a major complication especially in high-risk patients with advanced tumour stages and specific genetic aberrations, such as MYCN amplification and lp deletion. As an approach to...

journal_title：Cancer letters

authors： Paffhausen T,Schwab M,Westermann F

更新日期：2007-05-18 00:00:00

abstract：:The constitutional expression of heat shock proteins (HSP) 27, 70 and 90 in human breast, colon and ovarian cancer cells transplanted into severe combined immunodeficient (SCID) mice was evaluated. In addition their induced expression under chemotherapeutic stress was analyzed. The oestrogen receptor positive breast c...

journal_title：Cancer letters

authors： Katoh M,Koninkx J,Schumacher U

更新日期：2000-12-08 00:00:00

abstract：:Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade, Gli1 is also induced by non-canonical pathway...

journal_title：Cancer letters

authors： Dixit D,Ghildiyal R,Anto NP,Ghosh S,Sharma V,Sen E

更新日期：2013-08-19 00:00:00

abstract：:Based on the primer binding site for Phe-tRNA, human endogenous retroviruses (HERVs) have been classified as HERV-F family members, HERV-F, HERV-FXA, HERV-Fb, and HERV-Fc. The HERV-F family was expressed in human placenta preferentially. We investigated pol fragments of HERV-F family in various human tissues and cance...

journal_title：Cancer letters

authors： Yi JM,Kim HS

更新日期：2004-07-28 00:00:00

abstract：:N-α-Acetyltransferase 10 protein (Naa10p) mediates N-terminal acetylation of nascent proteins. Oncogenic or tumor suppressive roles of Naa10p were reported in cancers. Here, we report an oncogenic role of Naa10p in promoting metastasis of osteosarcomas. Higher NAA10 transcripts were observed in metastatic osteosarcoma...

journal_title：Cancer letters

authors： Chien MH,Lee WJ,Yang YC,Tan P,Pan KF,Liu YC,Tsai HC,Hsu CH,Wen YC,Hsiao M,Hua KT

更新日期：2018-10-01 00:00:00

abstract：:Pancreatic cancer is the most lethal tumor. CA125 (gene symbol MUC16) is an important serum marker for pancreatic cancer diagnosis and treatment. High serum CA125 is related to metabolic tumor burden and poor prognosis. The circulating Treg subset is another independent prognostic factor for pancreatic cancer. Our unp...

journal_title：Cancer letters

authors： Fan K,Yang C,Fan Z,Huang Q,Zhang Y,Cheng H,Jin K,Lu Y,Wang Z,Luo G,Yu X,Liu C

更新日期：2018-04-01 00:00:00

abstract：:Efficacy of a safe and clinically utilized polyethylene glycol formulation (PEG-3350) to suppress intestinal tumors was investigated in the Apc(min) mouse-model of experimental carcinogenesis. Furthermore, based on our previous finding on the induction of apoptosis in HT-29 cells by PEG, we evaluated its ability to st...

journal_title：Cancer letters

authors： Roy HK,Gulizia J,DiBaise JK,Karolski WJ,Ansari S,Madugula M,Hart J,Bissonnette M,Wali RK

更新日期：2004-11-08 00:00:00

abstract：:TRIOBP isoforms 4 and 5 (TRIOBP-4/-5) are an actin-bundling protein associated with hearing loss. Here, we showed that TRIOBP-4/-5 was up-regulated in human pancreatic carcinoma cells. Knockdown of TRIOBP-4/-5 led to a loss of filopodia and a decrease in cell motility. Confocal microscopy showed that re-expression of ...

journal_title：Cancer letters

authors： Bao J,Wang S,Gunther LK,Kitajiri S,Li C,Sakamoto T

更新日期：2015-01-28 00:00:00

abstract：:Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family, essential for mitotic spindle dynamics and centrosome integrity during mitosis. Mounting evidence suggests that deregulation of TACC3 is associated with various types of human cancer. However, the molecular mechanisms by which TACC3 cont...

journal_title：Cancer letters

authors： Ha GH,Park JS,Breuer EK

更新日期：2013-05-10 00:00:00

abstract：:Effect of CF(3)-STLC, a potent kinesin spindle protein (KSP) inhibitor, on K562 human CML cell line was investigated. Treatment with CF(3)-STLC induced mitotic arrest of the cell cycle with the appearance of characteristic monoastral spindles, subsequent apoptotic cell death and cleavage of PARP-1, caspase-3, and 4E-B...

journal_title：Cancer letters

authors： Shimizu M,Ishii H,Ogo N,Unno Y,Matsuno K,Sawada J,Akiyama Y,Asai A

更新日期：2010-12-01 00:00:00