Abstract：
:The constitutional expression of heat shock proteins (HSP) 27, 70 and 90 in human breast, colon and ovarian cancer cells transplanted into severe combined immunodeficient (SCID) mice was evaluated. In addition their induced expression under chemotherapeutic stress was analyzed. The oestrogen receptor positive breast cancer cell lines (MCF-7, T47D) demonstrated an increased level of HSP 27 and 70 expression compared with oestrogen receptor negative cell lines (BT20, HBL100). After 5-fluorouracil application for 4 days, HSP 27 and 70 expression was increased in HT29 colon tumours. Hence, the human/SCID mouse model is well suited to evaluate the constitutional and induced expression of human HSPs under various experimental conditions.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Katoh M,Koninkx J,Schumacher Udoi
10.1016/s0304-3835(00)00601-7keywords:
subject
Has Abstractpub_date
2000-12-08 00:00:00pages
113-20issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(00)00601-7journal_volume
161pub_type
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