Abstract:
:Calcium-stimulated, phospholipid dependent protein kinase C activity was found in cytosolic extracts of the epidermis of SENCAR, C57BL/6 and Ha/ICR mice. The enzymes were partially purified by DEAE-cellulose chromatography. There were no significant differences between the 3 strains in basal protein kinase C activity. The enzymes from all 3 strains were stimulated by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in the absence of calcium, but no correlation was seen between susceptibility to tumor promotion and any protein kinase C activity parameter measured.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Garte SJ,Edinger F,Mufson RAdoi
10.1016/0304-3835(85)90161-2subject
Has Abstractpub_date
1985-11-01 00:00:00pages
215-21issue
2eissn
0304-3835issn
1872-7980pii
0304-3835(85)90161-2journal_volume
29pub_type
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