RNA aptamers targeting cancer stem cell marker CD133.

abstract：:The incidence of pediatric cancers is rising steadily across the world, along with the challenges in understanding the molecular mechanisms and devising effective therapeutic strategies. Pediatric cancers are presented with diverse molecular characteristics and more distinct subtypes when compared to adult cancers. Re...

journal_title：Cancer letters

authors： Vellichirammal NN,Chaturvedi NK,Joshi SS,Coulter DW,Guda C

更新日期：2021-02-28 00:00:00

abstract：:Trypsin inhibitors have been shown to promote pancreatic growth as well as the development of pancreatic tumours in rats. The present study was carried out to examine the effects of the synthetic trypsin inhibitor camostate on the growth of the pancreas and on the development of pancreatic preneoplastic and neoplastic...

journal_title：Cancer letters

authors： Meijers M,van Garderen-Hoetmer A,Lamers CB,Rovati LC,Jansen JB,Woutersen RA

更新日期：1991-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Many kinases have been found to be intimately involved in oncogenesis and the deregulation of kinase function has emerged as a major mechanism by which cancer cells evade normal physiological constraints on growth and surviv...

journal_title：Cancer letters

authors： Xia H,Kong SN,Chen J,Shi M,Sekar K,Seshachalam VP,Rajasekaran M,Goh BKP,Ooi LL,Hui KM

更新日期：2016-12-01 00:00:00

abstract：:Our previous studies demonstrated that dietary garlic powder supplementation inhibits N-nitrosamine induced DNA alkylation in liver and mammary tissue. The present studies compared the impact of dietary supplementation with garlic powder or two garlic constituents, water-soluble S-allyl cysteine (SAC) and oil-soluble ...

journal_title：Cancer letters

authors： Schaffer EM,Liu JZ,Green J,Dangler CA,Milner JA

更新日期：1996-04-19 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several hum...

journal_title：Cancer letters

authors： Barboro P,Ferrari N,Balbi C

更新日期：2014-10-01 00:00:00

abstract：:We describe the events triggered by a sub-lethal concentration of airborne particulate matter (PM(10)) in A549 cells, which include the formation DNA double-strand breaks, gammaH2A.X generation, and 53BP1 recruitment. To protect the genome, cells activated ATM/ATR/Chk1/Chk2/p53 pathway but, after 48 h, cells turned in...

journal_title：Cancer letters

authors： Sánchez-Pérez Y,Chirino YI,Osornio-Vargas ÁR,Morales-Bárcenas R,Gutiérrez-Ruíz C,Vázquez-López I,García-Cuellar CM

更新日期：2009-06-18 00:00:00

abstract：:Glioblastoma (GBM) is a deadly and incurable brain tumor. Although microRNAs (miRNAs) play critical roles in regulating the cancer cell phenotype, the underlying mechanisms of how they regulate tumorigenesis are incompletely understood. We found that miR-1 is expressed at relatively low levels in brain cancer patients...

journal_title：Cancer letters

authors： Yang CH,Wang Y,Sims M,Cai C,Pfeffer LM

更新日期：2019-11-28 00:00:00

abstract：:Endometrial cancer is the leading gynecologic cancer in women in the United States with 52,630 women predicted to be diagnosed with the disease in 2014. The objective of this study was to determine if progesterone (P4) receptor membrane component 1 (PGRMC1) influenced endometrial cancer cell viability in response to c...

journal_title：Cancer letters

authors： Friel AM,Zhang L,Pru CA,Clark NC,McCallum ML,Blok LJ,Shioda T,Peluso JJ,Rueda BR,Pru JK

更新日期：2015-01-28 00:00:00

abstract：:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on ...

journal_title：Cancer letters

authors： Wu Y,Wang W,Yang AG,Zhang R

更新日期：2020-12-01 00:00:00

abstract：:The ability to induce changes in cell membrane properties is nowadays considered an additional mechanism to explain the pharmacological effects of non-steroidal anti-inflammatory drugs (NSAIDs). We previously demonstrated that the NSAID Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, triggers apoptosis in ...

journal_title：Cancer letters

authors： Tavolari S,Munarini A,Storci G,Laufer S,Chieco P,Guarnieri T

更新日期：2012-08-28 00:00:00

abstract：:The majority of ovarian cancer (OC) patients recur with a platinum-resistant disease. OC cells activate adaptive resistance mechanisms that are only partially described. Here we show that OC cells can adapt to chemotherapy through a positive-feedback loop that favors chemoresistance. In platinum-resistant OC cells we ...

journal_title：Cancer letters

authors： Tocci P,Cianfrocca R,Sestito R,Rosanò L,Di Castro V,Blandino G,Bagnato A

更新日期：2020-11-01 00:00:00

abstract：:We investigated a role for Hedgehog signalling in colon cancer by studying transcription of members of the pathway in human colorectal carcinoma cell lines. We determined the methylation status and screened the gene encoding the Hedgehog receptor-associated protein Smoothened (SMO) for putative mutations. In three cel...

journal_title：Cancer letters

authors： Zhu Y,James RM,Peter A,Lomas C,Cheung F,Harrison DJ,Bader SA

更新日期：2004-04-30 00:00:00

abstract：:Patients with pancreatic adenocarcinoma (PDAC) have a 5-year survival rate of 8%, the lowest of any cancer in the United States. Traditional chemotherapeutic regimens, such as gemcitabine- and fluorouracil-based regimens, often only prolong survival by months. Effective precision targeted therapy is therefore urgently...

journal_title：Cancer letters

authors： Liu SH,Yu J,Creeden JF,Sutton JM,Markowiak S,Sanchez R,Nemunaitis J,Kalinoski A,Zhang JT,Damoiseaux R,Erhardt P,Brunicardi FC

更新日期：2020-10-28 00:00:00

abstract：:Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 ...

journal_title：Cancer letters

authors： da Silva TC,Paula da Silva A,Akisue G,Luis Avanzo J,Kazumi Nagamine M,Fukumasu H,Matsuzaki P,César Raspantini P,Haraguchi M,Lima Górniak S,Dagli ML

更新日期：2005-08-26 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that cir...

journal_title：Cancer letters

authors： Zhou R,Wu Y,Wang W,Su W,Liu Y,Wang Y,Fan C,Li X,Li G,Li Y,Xiong W,Zeng Z

更新日期：2018-07-01 00:00:00

abstract：:Staurosporine (ST), a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on the proliferation of HT-29 colon adenocarcinoma cells; PKC is associated with increased colon cell proliferation. ST inhibited cell proliferation in a time- and concentration-dependent manner by up to 90%. It also blocked...

journal_title：Cancer letters

authors： Qiao L,Koutsos M,Tsai LL,Kozoni V,Guzman J,Shiff SJ,Rigas B

更新日期：1996-10-01 00:00:00

abstract：:Tumor tissues are chronically exposed to hypoxia owing to aberrant vascularity. Hypoxia induces metabolic alterations in cancer, thereby promoting aggressive malignancy and metastasis. While previous efforts largely focused on adaptive responses in glucose and glutamine metabolism, recent studies have begun to yield i...

journal_title：Cancer letters

authors： Povero D,Johnson SM,Liu J

更新日期：2020-11-28 00:00:00

abstract：:The potential of gadolinium neutron-capture therapy (Gd-NCT) for cancer was evaluated using chitosan nanoparticles as a novel gadolinium device. The nanoparticles, incorporating 1200 microg of natural gadolinium, were administered intratumorally twice in mice bearing subcutaneous B16F10 melanoma. The thermal neutron i...

journal_title：Cancer letters

authors： Tokumitsu H,Hiratsuka J,Sakurai Y,Kobayashi T,Ichikawa H,Fukumori Y

更新日期：2000-03-31 00:00:00

abstract：:Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-os...

journal_title：Cancer letters

authors： Zhang X,Connolly C,Duquette M,Lawler J,Parangi S

更新日期：2007-03-08 00:00:00

abstract：:Exosomes are biological nanovesicles that are involved in cell-cell communication via the functionally-active cargo (such as miRNA, mRNA, DNA and proteins). Because of their nanosize, exosomes are explored as nanodevices for the development of new therapeutic applications. However, bulk, safe and cost-effective produc...

journal_title：Cancer letters

authors： Munagala R,Aqil F,Jeyabalan J,Gupta RC

更新日期：2016-02-01 00:00:00

abstract：:Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study,...

journal_title：Cancer letters

authors： Kong Y,Zhang L,Huang Y,He T,Zhang L,Zhao X,Zhou X,Zhou D,Yan Y,Zhou J,Xie H,Zhou L,Zheng S,Wang W

更新日期：2017-10-28 00:00:00

abstract：:Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...

journal_title：Cancer letters

authors： Weber TH,Linkola J

更新日期：1980-01-01 00:00:00

abstract：:The effect of dose was evaluated for the bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT). The chemical was fed to male weanling F344 rats for 30 weeks followed by 74 weeks of control diet. The incidences of bladder carcinoma were 100, 100, 87, 0, 0 and 0% for doses of 0.2, 0.1, 0.05, 0...

journal_title：Cancer letters

authors： Arai M,St John M,Fukushima S,Friedell GH,Cohen SM

更新日期：1983-04-01 00:00:00

abstract：:Interstitial fluid pressure was measured by the wick-in-needle technique in DMBA-induced rat mammary tumours during resting conditions and during noradrenaline infusion. The rate of infusion was chosen to increase the systemic blood pressure by 30-40 mmHg, known to result in a markedly increased vascular resistance of...

journal_title：Cancer letters

authors： Tveit E,Hultborn R,Weiss L

更新日期：1985-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is a commonly diagnosed malignancy with unsatisfactory survival outcomes. Recent studies indicate that noncoding RNAs (ncRNAs) can be selectively packaged into exosomes, the extracellular vesicles composed of a lipid bilayer, and delivered from donor to recipient cells, thus regulating the beha...

journal_title：Cancer letters

authors： Wu Q,Liu W,Wang J,Zhu L,Wang Z,Peng Y

更新日期：2020-11-28 00:00:00

abstract：:The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...

journal_title：Cancer letters

authors： Yang C,Huang M,Li S,Chen J,Yang Y,Qin N,Huang D,Shu J

更新日期：2020-02-01 00:00:00

abstract：:The mixed lineage kinase domain-like protein (MLKL) has emerged as a critical mediator of necroptosis, which results in the release of cellular damage-associated molecular patterns (DAMPs). However, its physiological role in regulating inflammation is not fully understood. We herein showed that Mlkl-/- mice were highl...

journal_title：Cancer letters

authors： Zhao Q,Yu X,Li M,Liu Y,Han Y,Zhang X,Li XM,Wu X,Qin J,Fang J,Zhang H

更新日期：2019-09-10 00:00:00

abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

journal_title：Cancer letters

authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

更新日期：2013-05-01 00:00:00

abstract：:The presence and the involvement of cancer stem-like cells (CSCs) in tumor initiation and progression, and chemo-resistance are documented. Herein, we functionally analyzed melanoma stem-like cells (MSC)/CD133(+) cells on their resistance and response to taxol-induced apoptosis. Besides being taxol resistant, the CD13...

journal_title：Cancer letters

authors： El-Khattouti A,Selimovic D,Haïkel Y,Megahed M,Gomez CR,Hassan M

更新日期：2014-02-01 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, was tested for in vitro cytotoxicity against human laryngeal epidermoid carcinoma of the larynx Hep2 cells. EGCG-induced apoptotic cell death accompanied by a change in the cell cycle. However, EGCG did not result in caspase activation, nor did a cas...

journal_title：Cancer letters

authors： Lee JH,Jeong YJ,Lee SW,Kim D,Oh SJ,Lim HS,Oh HK,Kim SH,Kim WJ,Jung JY

更新日期：2010-04-01 00:00:00