Abstract:
:MicroRNAs (miRNAs) are a group of non-coding RNAs that play a crucial role in post-transcriptional gene regulation and act as indispensable mediators in several critical biological processes, including tumorigenesis, tissue homeostasis, and regeneration. MiR-424 and miR-503 are intragenic miRNAs that are clustered on human chromosome Xq26.3. Previous studies have reported that both miRNAs are dysregulated and play crucial but paradoxical roles in tumor initiation and progression, involving different target genes and molecular pathways. Moreover, these two miRNAs are concomitantly expressed in several cancer cells, indicating a coordinating function as a cluster. In this review, the roles and regulatory mechanisms of miR-424, miR-503, and miR-424/503 cluster are summarized in different types of cancers.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Wu Y,Wang W,Yang AG,Zhang Rdoi
10.1016/j.canlet.2020.08.027subject
Has Abstractpub_date
2020-12-01 00:00:00pages
58-72eissn
0304-3835issn
1872-7980pii
S0304-3835(20)30441-9journal_volume
494pub_type
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