Abstract:
:Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-osmotic pumps in vivo, and continuous administration of 3TSR decreased the dosage and improved the potency of therapy in an orthotopic pancreatic cancer model. By using different dosage and delivery routes, we proved that the anti-tumor efficacy of 3TSR was correlated with its anti-angiogenic efficacy. 3TSR treatment also decreased tumor vessel patency and blood flow. The results indicate the advantage of continuous administration of angiogenic inhibitors and provide rationale for using such delivery methods for cancer treatment.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Zhang X,Connolly C,Duquette M,Lawler J,Parangi Sdoi
10.1016/j.canlet.2006.04.003subject
Has Abstractpub_date
2007-03-08 00:00:00pages
143-9issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(06)00216-3journal_volume
247pub_type
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