Interactions of antitumor drug ditercalinium with nucleic acids in solutions and in situ.

abstract：:The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced apoptosis and appears to function as a transcription factor in multiple diseases. However, its potential contributions to...

journal_title：Cancer letters

authors： Tan W,Liao Y,Qiu Y,Liu H,Tan D,Wu T,Tang M,Zhang S,Wang H

更新日期：2018-08-01 00:00:00

abstract：:The Chinese Glioma Cooperative Group (CGCG) Guideline Panel for adult diffuse gliomas provided recommendations for diagnostic and therapeutic procedures. The Panel covered all fields of expertise in neuro-oncology, i.e. neurosurgeons, neurologists, neuropathologists, neuroradiologists, radiation and medical oncologist...

journal_title：Cancer letters

authors： Jiang T,Mao Y,Ma W,Mao Q,You Y,Yang X,Jiang C,Kang C,Li X,Chen L,Qiu X,Wang W,Li W,Yao Y,Li S,Li S,Wu A,Sai K,Bai H,Li G,Chen B,Yao K,Wei X,Liu X,Zhang Z,Dai Y,Lv S,Wang L,Lin Z,Dong J,Xu G,M

更新日期：2016-06-01 00:00:00

abstract：:Despite the improved 5-year survival rate of breast cancer, triple-negative breast cancer (TNBC) remains a challenge due to lack of effective targeted therapy and higher recurrence and metastasis than other subtypes. To identify novel druggable targets and to understand its unique biology, we tried to implement 24 pat...

journal_title：Cancer letters

authors： Jung J,Jang K,Ju JM,Lee E,Lee JW,Kim HJ,Kim J,Lee SB,Ko BS,Son BH,Lee HJ,Gong G,Ahn SY,Choi JK,Singh SR,Chang S

更新日期：2018-08-01 00:00:00

abstract：:Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because of its highly invasive nature. In recent years, there has been a growing appreciation for the role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence of GBM. GSC...

journal_title：Cancer letters

authors： Nakod PS,Kim Y,Rao SS

更新日期：2018-08-10 00:00:00

abstract：:Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known ab...

journal_title：Cancer letters

authors： Sun J,Luo Q,Liu L,Song G

更新日期：2018-07-28 00:00:00

abstract：:Activation of the BTLA-HVEM co-inhibitory signaling pathway impairs antitumor immunity. Our previous study demonstrated that the extracellular domain of murine BTLA (the soluble form of BTLA) can facilitate HSP70 vaccine-triggered antitumor immunity by blocking BTLA-HVEM interactions in a murine TC-1 non-metastatic tu...

journal_title：Cancer letters

authors： Han L,Wang W,Lu J,Kong F,Ma G,Zhu Y,Zhao D,Zhu J,Shuai W,Zhou Q,Chen P,Ye L,Tao J,Ahmad S,Li F,Sun J

更新日期：2014-11-28 00:00:00

abstract：:Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing...

journal_title：Cancer letters

authors： Balassiano K,Lima S,Jenab M,Overvad K,Tjonneland A,Boutron-Ruault MC,Clavel-Chapelon F,Canzian F,Kaaks R,Boeing H,Meidtner K,Trichopoulou A,Laglou P,Vineis P,Panico S,Palli D,Grioni S,Tumino R,Lund E,Bueno-de-Mesqui

更新日期：2011-12-01 00:00:00

abstract：:To search for possible cancer chemopreventive agents from natural sources, we performed primary screening of ten flavanones isolated from plants belonging to Rutaceae and Leguminosae by examining their possible inhibitory effects on Epstein-Barr virus (EBV) early antigen activation induced by 12-O-tetradecanoylphorbol...

journal_title：Cancer letters

authors： Itoigawa M,Ito C,Ju-ichi M,Nobukuni T,Ichiishi E,Tokuda H,Nishino H,Furukawa H

更新日期：2002-02-08 00:00:00

abstract：:Artesunate (ART), a semi-synthetic derivative of artemisinin extracted from the Chinese herb Artemisia annua, is a safe and effective antimalarial drug. ART has now been analyzed for its anti-angiogenic activity in vivo and in vitro. The anti-angiogenic effect in vivo was evaluated on chicken chorioallantoic membrane ...

journal_title：Cancer letters

authors： Huan-huan C,Li-Li Y,Shang-Bin L

更新日期：2004-08-10 00:00:00

abstract：:The tissue-specific glycosylation of the carcinoma (CA)-associated antigen epithelial cell adhesion molecule (EpCAM) was studied in 60 patients suffering from head and neck CAs, and 26 pairs of autologous healthy thyroid and CA biopsies. EpCAM was glycosylated in all tumor samples in which its expression was detectabl...

journal_title：Cancer letters

authors： Pauli C,Münz M,Kieu C,Mack B,Breinl P,Wollenberg B,Lang S,Zeidler R,Gires O

更新日期：2003-04-10 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) is an attractive target for cancer vaccine. However, autoimmune tolerance prevents vaccines based on HER2 protein from inducing long-lasting, highly effective anti-tumor immunity. In this study, we proved that the introduction of p-nitrophenylalanine in the universal T c...

journal_title：Cancer letters

authors： Tian H,He Y,Song X,Jiang L,Luo J,Xu Y,Zhang W,Gao X,Yao W

更新日期：2018-08-28 00:00:00

abstract：:Tumor-associated macrophages (TAMs) are important immunocytes associated with cancer metastasis. However, whether TAMs play a dominant role in mediating CXCL12/CXCR4-induced liver metastasis of colorectal cancer (CRC) remains unexplored. Herein, we found that CD206+ TAMs, which infiltrated at the invasive front, were ...

journal_title：Cancer letters

authors： Wang D,Wang X,Si M,Yang J,Sun S,Wu H,Cui S,Qu X,Yu X

更新日期：2020-04-01 00:00:00

abstract：:The Wnt signaling pathway has long been known to direct growth and patterning during embryonic development. Recent evidence also implicates this pathway in the development of childhood tumors of the liver, the kidney, the brain, and the pancreas. Here, we review the current evidence on how constitutive activation of t...

journal_title：Cancer letters

authors： Koesters R,von Knebel Doeberitz M

更新日期：2003-08-20 00:00:00

abstract：:An apoptosis-inducing protein with molecular weight of 60 kDa has been purified from fetal bovine serum. The N-terminal amino acid sequence of this protein (e.g. I-P-L-D-P-V-A-G-Y-K) reveals that it is bovine fetuin, a fetal protein functioning to control embryogenesis. The apoptosis-inducing activity of fetuin is tot...

journal_title：Cancer letters

authors： Yu CL,Tsai MH

更新日期：2001-05-26 00:00:00

abstract：:Hypoxia-inducible factor 1 alpha (HIF-1 alpha) that regulates genes involved in response to hypoxia and promotes neo-angiogenesis, is a transcriptional factor for vascular endothelial cell growth factor (VEGF). The aim of this study was to examine the expression of HIF-1 alpha and VEGF gene expressions and their relat...

journal_title：Cancer letters

authors： Nakayama K,Kanzaki A,Hata K,Katabuchi H,Okamura H,Miyazaki K,Fukumoto M,Takebayashi Y

更新日期：2002-02-25 00:00:00

abstract：:Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are ...

journal_title：Cancer letters

authors： Weber TH,Linkola J

更新日期：1980-01-01 00:00:00

abstract：:CD133 is a surface marker of liver cancer stem cells. Transmembrane 4 L six family member 5 (TM4SF5) promotes sphere growth and circulation. However, it is unknown how CD133 and TM4SF5 cross-talk with each other for cancer stem cell properties. Here, we investigated the significance of inter-relationships between CD13...

journal_title：Cancer letters

authors： Kim S,Cho CY,Lee D,Song DG,Kim HJ,Jung JW,Kim JE,Park D,Lee H,Um H,Park J,Choi Y,Kim Y,Nam SH,Lee JW

更新日期：2018-12-01 00:00:00

abstract：:Here in, we investigated the mechanism underlying overexpression of miR-135b in the human head and neck squamous cell carcinoma (HNSCC) cell lines and in the HNSCC mouse model. Exogenous expression of miR-135b in these cell lines increased cell proliferation, migration, and colony formation. Gene silencing analysis re...

journal_title：Cancer letters

authors： Zhang L,Sun ZJ,Bian Y,Kulkarni AB

更新日期：2013-05-01 00:00:00

abstract：:Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here, we investigated the molecular mechanism by which EB1 regulates apoptosis in H460, A549, and H1299 cells. Depletion of EB1 in A549 and H1299...

journal_title：Cancer letters

authors： Kim MJ,Yun HS,Hong EH,Lee SJ,Baek JH,Lee CW,Yim JH,Kim JS,Park JK,Um HD,Hwang SG

更新日期：2013-10-01 00:00:00

abstract：:Tamoxifen (TAM)-induced DNA adduct formation in mouse skin was determined by a nuclease P1-enhanced 32P-postlabelling technique. Topical application of TAM significantly induced a number of DNA-adducts in mouse skin in a dose- and time-dependent manner. When SENCAR mice were topically treated with different doses of T...

journal_title：Cancer letters

authors： Cai Q,Wei H

更新日期：1995-06-08 00:00:00

abstract：:In vitro cytotoxicity tests currently in use applied in the developmental stages of anticancer drug discovery are able to select the most potent compounds, but are not predictive of their potential toxicity. In this study, we have demonstrated the applicability of neutral red uptake assay using mouse fibroblasts Balb/...

journal_title：Cancer letters

authors： Popiołkiewicz J,Polkowski K,Skierski JS,Mazurek AP

更新日期：2005-11-08 00:00:00

abstract：:Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung...

journal_title：Cancer letters

authors： Castañón E,Soltermann A,López I,Román M,Ecay M,Collantes M,Redrado M,Baraibar I,López-Picazo JM,Rolfo C,Vidal-Vanaclocha F,Raez L,Weder W,Calvo A,Gil-Bazo I

更新日期：2017-08-28 00:00:00

abstract：:Ibrutinib, an inhibitor of Bruton tyrosine kinase (BTK), has shown promising pharmacologic effects in acute myeloid leukemia (AML). In this study, we report that abivertinib or AC0010, a novel BTK inhibitor, inhibits cell proliferation, reduces colony-forming capacity, and induces apoptosis and cell cycle arrest in AM...

journal_title：Cancer letters

authors： Huang S,Pan J,Jin J,Li C,Li X,Huang J,Huang X,Yan X,Li F,Yu M,Hu C,Jin J,Xu Y,Ling Q,Ye W,Wang Y,Jin J

更新日期：2019-10-01 00:00:00

abstract：:Tumour cell attachment to the endothelial cell lining of the circulatory system is of utmost importance in the process of cancer spread. We describe here a method of quantifying tumour cell attachment to an endothelial cell layer in vitro, using the fluorescent carbocyanine dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethyli...

journal_title：Cancer letters

authors： Hiscox S,Jiang WG

更新日期：1997-01-30 00:00:00

abstract：:Various dose levels of benzo[a]pyrene (BP) were tested on short-term cultured foetal hamster lung cells for transforming effects in vitro in 6 similar experiments. The statistical evaluation of the results indicated a weak reproducibility (P = 0.09). Factors which inherently influence such reproducibility were conside...

journal_title：Cancer letters

authors： Richter-Reichhelm HB,Emura M,Schneider P,Mohr U

更新日期：1979-11-01 00:00:00

abstract：:The study describes the kinetics of demethylation of mononitrosocaffeidine (MNC), a new asymmetric N-nitrosamine derived from caffeine. The demethylation of its precursor compound caffeidine was also studied. The results presented here suggest (a) that liver microsomes from fasted rats preferentially demethylate the N...

journal_title：Cancer letters

authors： Razdan R,Frei E,Spiegelhalder B,Siddiqi M

更新日期：1994-04-29 00:00:00

abstract：:Cancer stem cells (CSCs), which comprise a small proportion of total cancer cells, have special capacities for self-renewal, differentiation and tumor formation. Currently, CSCs are regarded as the major cause of the failure in anticancer therapy, such as chemoresistance and/or radioresistance, tumor recurrence and me...

journal_title：Cancer letters

authors： Lei Y,Zhang D,Yu J,Dong H,Zhang J,Yang S

更新日期：2017-05-01 00:00:00

abstract：:As a tumor antigen, mesothelin (MSLN) can be identified in various malignancies. MSLN is potential for antigen-specific cancer vaccines. We generated a novel chimeric DNA vaccine using antigen-specific connective tissue growth factor lined with MSLN (CTGF/MSLN). The anti-tumor effects of the CTGF/MSLN DNA vaccine comb...

journal_title：Cancer letters

authors： Chen YL,Chang MC,Chiang YC,Lin HW,Sun NY,Chen CA,Sun WZ,Cheng WF

更新日期：2018-07-01 00:00:00

abstract：:The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy w...

journal_title：Cancer letters

authors： Deangelo AB,Garrett CT

更新日期：1983-09-01 00:00:00

abstract：:Cancerous breast hyperthermia is seemingly associated with non-neurological vasodilation modulated by nitric oxide (NO). NO, associated with enhanced immune response, is produced autocatalytically involving ferritin as the supplier of Fe2+, which catalyses the formation of NO. NO, in turn, releases Fe2+ from ferritin....

journal_title：Cancer letters

authors： Anbar M

更新日期：1994-08-29 00:00:00