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Tumor-specific glycosylation of the carcinoma-associated epithelial cell adhesion molecule EpCAM in head and neck carcinomas.

Abstract：

:The tissue-specific glycosylation of the carcinoma (CA)-associated antigen epithelial cell adhesion molecule (EpCAM) was studied in 60 patients suffering from head and neck CAs, and 26 pairs of autologous healthy thyroid and CA biopsies. EpCAM was glycosylated in all tumor samples in which its expression was detectable (73%). Additionally, in 80.7% of patients, tumor-derived EpCAM was heavily glycosylated while EpCAM derived from autologous thyroid was not (76.2%) or weakly (23.8%). Four cases showed a similar glycosylation pattern (15.3%) and one case displayed a reverse pattern (3.8%). Additionally, the expression and glycosylation of EpCAM were assessed in tumor adjacent and distant tissue. EpCAM was glycosylated in tumor-adjacent while it was not or only weakly expressed in tumor distant tissue where it was unglycosylated. Thus, EpCAM is differentially glycosylated in healthy tissue and tumor cells of the head and neck area.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Pauli C,Münz M,Kieu C,Mack B,Breinl P,Wollenberg B,Lang S,Zeidler R,Gires O

doi

10.1016/s0304-3835(03)00003-x

keywords:

subject

Has Abstract

pub_date

2003-04-10 00:00:00

pages

25-32

issue

1

eissn

0304-3835

issn

1872-7980

pii

S030438350300003X

journal_volume

193

pub_type

杂志文章

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