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Hypoxia and hypoxia inducible factors in tumor metabolism.

Abstract：

:Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting energy production from mitochondria towards glycolysis. In this review, we focus on the metabolism of tumor cell survival in hypoxic microenvironments. Furthermore, we also emphasize the mechanisms by which hypoxia and HIFs regulate tumor metabolism.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Zeng W,Liu P,Pan W,Singh SR,Wei Y

doi

10.1016/j.canlet.2014.01.032

subject

Has Abstract

pub_date

2015-01-28 00:00:00

pages

263-7

issue

2 Pt A

eissn

0304-3835

issn

1872-7980

pii

S0304-3835(14)00089-5

journal_volume

356

pub_type

杂志文章,评审

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