Abstract:
:The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several human cancers and its aberrant cytoplasmic localization has been associated with a worse prognosis for patients, suggesting that it has a role in cancer progression. Herein, we provide a brief overview of the multifunctional roles of hnRNP K and discuss clinical studies that have demonstrated its involvement in cancer development and progression.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Barboro P,Ferrari N,Balbi Cdoi
10.1016/j.canlet.2014.06.019subject
Has Abstractpub_date
2014-10-01 00:00:00pages
152-9issue
2eissn
0304-3835issn
1872-7980pii
S0304-3835(14)00335-8journal_volume
352pub_type
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