Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.

Abstract:

:d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, which produced changes in melanoma cells similar to those produced by vitamin E succinate, also increased cAMP-dependent PK activity without changing the intracellular level of cAMP.

journal_name

Cancer Lett

journal_title

Cancer letters

authors

Torelli S,Masoudi F,Prasad KN

doi

10.1016/0304-3835(88)90097-3

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

129-36

issue

2

eissn

0304-3835

issn

1872-7980

pii

0304-3835(88)90097-3

journal_volume

39

pub_type

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