Abstract:
:To investigate mucin expression in breast cancer, immunohistochemical staining was performed on 30 mucinous carcinomas and 95 non-mucinous invasive carcinomas. MUC2 expression was detected in all mucinous carcinomas, but only in 11.1% of invasive ductal carcinomas, and in none of the invasive lobular carcinomas and medullary carcinomas. MUC1 is often expressed in invasive breast carcinoma, but not in medullary carcinoma. Strong cytoplasmic staining was seen in invasive ductal carcinoma, in contrast to surface membrane staining in mucinous carcinoma and intracytoplasmic vacuole staining in invasive lobular carcinoma. CA19-9 and CA50 expression in more than 25% of tumor cells was seen in 17.2 and 16.0% of invasive ductal carcinomas, respectively, but not in mucinous carcinomas. CA125 and human gastric mucin were rarely expressed in breast cancer, irrespective of histologic type.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Chu JS,Chang KJdoi
10.1016/s0304-3835(99)00161-5keywords:
subject
Has Abstractpub_date
1999-07-19 00:00:00pages
121-7issue
1eissn
0304-3835issn
1872-7980pii
S0304-3835(99)00161-5journal_volume
142pub_type
杂志文章相关文献
CANCER LETTERS文献大全abstract::The objective of this work was to investigate the expression of glutathione S-transferase placental form (GST-P) in 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Lesions were classified histopathologically into four categories, simple hyperplasia, papillary and nodular (PN) hyper...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(98)00286-9
更新日期:1999-01-29 00:00:00
abstract::The present study was performed to investigate the possible role of mTOR inhibitors in restoring chemosensitivity to adriamycin/cisplatin and elucidate the underlying mechanism. Combining adriamycin/cisplatin with torisel synergistically inhibited the cell proliferation in human oropharyngeal carcinoma cell line KB an...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2011.06.005
更新日期:2011-12-01 00:00:00
abstract::The mammary carcinogenicity of two diol epoxide metabolites of the commonly occurring environmental carcinogen benzo[j]fluoranthene (BjF) was investigated by direct application to the tissue beneath the mammary glands of female CD rats. The compounds tested were trans-4,5-dihydroxy-anti-6,6a.epoxy-4,5,6,6a-tetrahydroB...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(96)04328-5
更新日期:1996-09-10 00:00:00
abstract::The chemokine CXCL12 (SDF-1) and its receptor, CXCR4, have been implicated in organ-specific metastases of several malignancies. Head and neck squamous cell carcinoma (HNSCC) predominantly metastasizes to lymph nodes, and recent evidence has shown that CXCL12 stimulates HNSCC migration. We explored the potential role ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2004.04.035
更新日期:2004-10-28 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor in Chief. The term miR-143 has been used instead of the term miR-143* in the introduction and discussion which is misleading...
journal_title:Cancer letters
pub_type: 杂志文章,收录出版
doi:10.1016/j.canlet.2016.01.023
更新日期:2016-04-01 00:00:00
abstract::Cancer cachexia patients experience significant muscle wasting, which impairs the quality of life and treatment efficacy for patients. Skeletal muscle protein turnover is imparted by increased expression of ubiquitin-proteasome pathway components. Mitogen-activated protein kinases p38 and ERK have been shown to augmen...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2020.07.025
更新日期:2020-10-28 00:00:00
abstract::To define the critical region of liver-specific tumor suppressor genes in human hepatocellular carcinoma (HCC), we analyzed 30 cases of hepatocellular carcinoma using nine 4q and six 16q microsatellite polymorphic DNA markers. We observed one major common deleted region which was flanked by D4S175-D4S1625 and there ma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00276-0
更新日期:1998-01-16 00:00:00
abstract::Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IG...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2018.06.008
更新日期:2018-09-28 00:00:00
abstract::Gastrin-releasing peptide (GRP) activates phosphatidylinositol 3-kinase (PI3-K)/Akt, an important cell survival signaling pathway, to stimulate growth of various cell types. Transforming growth factor (TGF) superfamily ligands activate intracellular Smad signaling to regulate cell growth, differentiation and apoptosis...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2005.11.007
更新日期:2006-10-28 00:00:00
abstract::Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted by several genetic aberrations driving malignant cells into an un...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2016.05.012
更新日期:2016-08-10 00:00:00
abstract::We studied the influence of the vitamins retinol acetate, alpha-tocopherol acetate and thiamine chloride; the antioxidant sodium selenite and an inhibitor of polyamine biosynthesis, alpha-difluoromethylornithine, on the offspring of transplacental carcinogenesis by ethylnitrosourea in rats. Ethylnitrosourea was given ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(91)90225-7
更新日期:1991-11-01 00:00:00
abstract::Formation of DNA-adducts by 3-BHA or its metabolites, i.e., tert-butyl-1,4-benzoquinone (TBQ) and 5-methoxy-3-tert-butyl-1,2-benzoquinone (3-TBOQ), as well as DNA-adduct formation by 4-nitroquinoline-N-oxide (4NQO), in rat forestomach were examined by an enzymatic 32P-postlabeling assay. Four DNA-adducts were clearly ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(89)90117-1
更新日期:1989-12-01 00:00:00
abstract::Dioxane, perchloroethylene, and trichloroethylene were investigated as rat liver altered foci promoters in an initiation/promotion protocol. Animals were initiated with diethylnitrosamine, 30 mg/kg, injected i.p. 24 h after 2/3 partial hepatectomy. The chemical under study was administered by gavage once a day, 5 time...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(87)90099-1
更新日期:1987-07-01 00:00:00
abstract::Interferon-beta (IFN-β) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-β, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN-β-induced increase in endogenous PML contri...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.04.013
更新日期:2012-10-28 00:00:00
abstract::The identification of frameshift mutations in the coding region of the bax gene in Western cases of hereditary non-polyposis colorectal cancer provided evidence that the disease could be caused by the disruption of a tumor suppressor gene associated with microsatellite instability. In order to determine whether this o...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(97)00477-1
更新日期:1998-02-27 00:00:00
abstract::The capacity of the human adrenal gland to metabolize various xenobiotics was investigated. Adrenal microsomal and mitochondrial preparations showed a maximal absorption at 450 nm for dithionite-reduced cytochromes in the presence of carbon monoxide. Occasionally, absorption maxima at 448 nm were observed with both mi...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(84)90039-9
更新日期:1984-02-01 00:00:00
abstract::The p53 mutations in betel-related oral cancer have been studied but the results may be confounded by tobacco and alcohol due to tobacco components in the quid or concomitant habits of smoking and drinking. In this study, p53 mutations in tumors from Thai betel chewers who neither smoke nor drink were studied in compa...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(03)00417-8
更新日期:2003-11-10 00:00:00
abstract::Background is presented to suggest that a great many biologic processes are chaotic. It is well known that chaotic processes can be accurately characterized by non-linear technologies. Evidence is presented that an artificial neural network, which is a known method for the application of non-linear statistics, is able...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/0304-3835(94)90090-6
更新日期:1994-03-15 00:00:00
abstract::The immune repertoire (IR) refers to the sum of B cells and T cells with functional diversity in the circulatory system of one individual at any given time. Immune cells, which reside within microenvironments and are responsible for protecting the human body, include T cells, B cells, macrophages, and dendritic cells....
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2015.06.022
更新日期:2016-09-01 00:00:00
abstract::In order to examine the in vivo genotoxic activity of dichlorvos, lambdalacZ transgenic mice (Muta Mouse) were treated i.p. with single (4.4 or 11 mg/kg) or multiple (5 x 11 mg/kg) doses of this agent and sacrificed 4 h or 14 days post-treatment for DNA adduct measurement or mutant frequency analysis, respectively. Ne...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(99)00256-6
更新日期:1999-11-15 00:00:00
abstract::The aim of this study was to evaluate diagnostic performance of radiomics models of MRI in the detection of differentiation degree (DD) and lymph node metastases (LNM) of extrahepatic cholangiocarcinoma (ECC). We retrospectively enrolled 100 patients with ECC confirmed by pathology from January 2011 to December 2018. ...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2019.11.036
更新日期:2020-02-01 00:00:00
abstract::Transduction of the human interleukin-2 (IL-2) gene into tumor cells was carried out in order to develop a new immunotherapy for advanced head and neck carcinomas with a poor outcome. We transduced the IL-2 gene into KB cells, a head and neck squamous cell carcinoma cell line, using a defective herpes simplex viral (H...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(00)00336-0
更新日期:2000-05-01 00:00:00
abstract::Recent evidence suggests that the cut-off for age utilized in neuroblastoma risk groups should be increased from the 365-day cut-off currently in use. Separate cooperative group analyses were performed by German and Italian groups and two analyses by the Children's Oncology Group (North America, Australia, New Zealand...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2004.12.054
更新日期:2005-10-18 00:00:00
abstract::Although it is well known that ovarian endometriosis occasionally gives rise to ovarian cancers with specific histology such as endometrioid and clear cell carcinomas, its etiology is not fully understood. We have shown that a stressful microenvironment within the endometriotic cyst may lead to cancer development by i...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2011.06.039
更新日期:2011-11-28 00:00:00
abstract::An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, t...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2013.09.005
更新日期:2015-01-01 00:00:00
abstract::BRCA1 and BRCA2 genes were screened for loss-of-function mutations in a series of 85 patients having at least one first- or second-degree relative affected by breast and/or ovarian cancer. All BRCA1 exons and BRCA2 exons 10 and 11 were screened with a combination of methods including SSCP, PTT and direct sequencing. W...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00845-x
更新日期:2002-11-08 00:00:00
abstract::Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross-complementing group 1 (XRCC1), XRCC3 and apurinic/apyrimidinic endonuclease/redox factor 1 were examined within a randomized clinical trial designed to determin...
journal_title:Cancer letters
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0304-3835(02)00638-9
更新日期:2003-03-10 00:00:00
abstract::CD95, TNFR1, TRAILR1 and TRAILR2 belong to a subgroup of TNF receptors which is characterized by a conserved cell death-inducing protein domain that connects these receptors to the apoptotic machinery of the cell. Activation of death receptors in malignant cells attracts increasing attention as a principle to fight ca...
journal_title:Cancer letters
pub_type: 杂志文章,评审
doi:10.1016/j.canlet.2010.12.019
更新日期:2013-05-28 00:00:00
abstract::Development of antiandrogen-resistance in advanced prostate cancer involves multiple androgen receptor (AR)-dependent and -independent pathways. Here, we demonstrated that endothelial nitric oxide synthase (eNOS) exhibited an overexpression pattern in hormone-refractory prostate cancer and several models of advanced h...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/j.canlet.2012.09.006
更新日期:2013-01-01 00:00:00
abstract::Arginine deiminase (ADI), isolated from Mycoplasma cell extracts, has been suggested to inhibit endothelial cell growth in vitro. However, anti-angiogenic activity by ADI has not yet been demonstrated. In this study, we investigated the in vitro effect of recombinant ADI (rADI) on the growth, migration, and tube forma...
journal_title:Cancer letters
pub_type: 杂志文章
doi:10.1016/s0304-3835(01)00793-5
更新日期:2002-09-26 00:00:00