Abstract:
:Dibenzoylmethane (DBM), a minor beta-diketone constituent of licorice and sunscreens, has been shown to exhibit anti-neoplastic effects in chemically induced skin and mammary cancers in several animal models. To date, no mechanism for the growth inhibitory effects of DBM on prostate cancer cells has been proposed. In this study, we examined the effects of DBM on the growth and cell cycle kinetics of several human prostate carcinoma cell lines. Using an MTT cytotoxicity assay, IC50 values of 25-100 microM were observed following 72 h exposure to DBM. LNCaP, DU145, and PC-3 prostate carcinoma cell lines were particularly sensitive in comparison to the cells with the vehicle alone. Flow cytometric analyses showed deregulation of the cell cycle, which correlated with the observed cytostatic effects of DBM in prostate carcinoma cells. These data suggest a potential role for DBM in the prevention and treatment of prostate cancer.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Jackson KM,DeLeon M,Verret CR,Harris WBdoi
10.1016/s0304-3835(01)00844-8keywords:
subject
Has Abstractpub_date
2002-04-25 00:00:00pages
161-5issue
2eissn
0304-3835issn
1872-7980pii
S0304383501008448journal_volume
178pub_type
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