Abstract:
:Polyphenolic antioxidants protected against Al-phthalocyanine tetrasulfonate-sensitized photohemolysis of human erythrocytes. A quantitative structure-activity relationship has been obtained to describe the protective effects of di- and trihydroxybenzenes: log cI(50) (microM)=(1.8620+/-1.5565)+(3.6366+/-2.8245) E(1)(7) (V)-(0. 4034+/-0.0765) log P (r(2)=0.8367), where cI(50) represents the concentrations of compounds for the 2-fold increase in the lag-phase of hemolysis, E(1)(7) represents the compound single-electron oxidation potential, and P represents the octanol/water partition coefficient. The cI(50) for quercetin and taxifolin were close, and cI(50) for morin, kaempferol and hesperetin were lower than might be predicted by this equation. The protection from hemolysis by azide, a quencher of singlet oxygen ((1)O(2)) was accompanied by increase in cI(50) of polyphenols, indicating that azide and polyphenols competed for the same damaging species, (1)O(2). These findings point out to two factors, determining the protective efficiency of polyphenols against (1)O(2), namely, ease of electron donation and lipophilicity.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Maroziene A,Kliukiene R,Sarlauskas J,Cenas Ndoi
10.1016/s0304-3835(00)00469-9keywords:
subject
Has Abstractpub_date
2000-08-31 00:00:00pages
39-44issue
1eissn
0304-3835issn
1872-7980pii
S0304383500004699journal_volume
157pub_type
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