Abstract：
:The antagonism by 3 synthetic steroids of the induction of tyrosine aminotransferase and tryptophan dioxygenase by dexamethasone were compared in HTC and FAZA hepatoma cells and in isolated liver cells. It was observed: (i) the sensitivity of liver cells to glucocorticoid agonists and antagonists changed in relation to time of culture; (ii) the extent of the inhibitory effect on enzyme induction depends on the nature of the antagonist; (iii) hepatoma cells, especially HTC cells, appeared more sensitive to glucocorticoid antagonism than liver cells.
journal_name
Cancer Lettjournal_title
Cancer lettersauthors
Santana MA,Chasserot-Bolaz S,Beck B,Pogson CIdoi
10.1016/0304-3835(85)90192-2subject
Has Abstractpub_date
1985-07-01 00:00:00pages
329-37issue
3eissn
0304-3835issn
1872-7980pii
0304-3835(85)90192-2journal_volume
27pub_type
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